Nucleoside Analog/Antimetabolite

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Nucleoside Analog/Antimetabolite Products

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Catalog No. Product Name Information Product Use Citations Product Validations
S1149 Gemcitabine (LY-188011) HCl Gemcitabine (LY-188011, NSC 613327) HCl is a DNA synthesis inhibitor with IC50 of 50 nM, 40 nM, 18 nM and 12 nM in PANC1, MIAPaCa2, BxPC3 and Capan2 cells, respectively.
Cell, 2021, 184(25):6119-6137.e26
Nat Commun, 2021, 12(1):4917
Nat Commun, 2021, 12(1):1602
S1200 Decitabine (NSC 127716) Decitabine (NSC 127716, Deoxycytidine, Dacogen, 5-aza-2-deoxycytidine, 5-AZA-dC, 5-aza-CdR) is a DNA methyltransferase inhibitor, incorporating into DNA and resulting in hypomethylation of DNA and intra-S-phase arrest of DNA replication. It is used to treat myelodysplastic syndrome (MDS). Decitabine induces cell cycle arrest and apoptosis in various cancer cell lines.
Cancer Cell, 2021, S1535-6108(21)00659-0
Cell Metab, 2021, 33(1):110-127.e5
J Immunother Cancer, 2021, 9(7)e002528
S1209 Fluorouracil (5-Fluorouracil, 5-FU) Fluorouracil (5-Fluorouracil, 5-FU, NSC 19893) is a DNA/RNA synthesis inhibitor, which interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS) in tumor cells. Fluorouracil induces apoptosis and can be used in the treatment of HIV.
Cell, 2021, 184(25):6119-6137.e26
Sci Adv, 2021, 7(36):eabh1684
Nat Commun, 2021, 12(1):4840
S1491 Fludarabine (NSC 118218) Fludarabine (NSC 118218, FaraA, Fludarabinum) is a STAT1 activation inhibitor which causes a specific depletion of STAT1 protein (and mRNA) but not of other STATs. Also a DNA synthesis inhibitor in vascular smooth muscle cells. Fludarabine induces apoptosis.
Cell Metab, 2021, 33(1):110-127.e5
Cell Rep, 2021, 34(1):108584
Cell Rep, 2021, 34(1):108584
S1648 Cytarabine (U-19920A) Cytarabine (U-19920A, Cytarabin, Ara-C, Arabinofuranosyl Cytidine, Cytosine β-D-arabinofuranoside, Cytosine arabinoside, NSC 63878, NSC 287459) is an antimetabolic agent and DNA synthesis inhibitor with IC50 of 16 nM in wild-type CCRF-CEM cells. Cytarabine induces autophagy and apoptosis.
Leukemia, 2021, 10.1038/s41375-021-01361-8
Blood Cancer J, 2021, 11(6):111
Cell Rep, 2021, 36(7):109559
S1807 Aciclovir (BW 248U) Acyclovir (BW 248U, Acyclovir, Acycloguanosine, Zovirax, ACV, NSC 645011) is a synthetic nucleoside analogue active against herpesviruses. Acyclovir induces cell cycle perturbation and apoptosis in Jurkat leukemia cells.
Microbiol Spectr, 2021, 9(3):e0064621
Front Microbiol, 2021, 12:722748
Vet Microbiol, 2021, 265:109313
S1647 Adenosine Adenosine is a nucleoside composed of a molecule of adenine attached to a ribose sugar molecule (ribofuranose) moiety via a β-N9-glycosidic bond.
Cancer Lett, 2021, 522:80-92
Front Cell Neurosci, 2018, 12:139
ACS Appl Mater Interfaces, 2016, 8(39):25818-25824
S1714 Gemcitabine (LY-188011) Gemcitabine (LY-188011, NSC 613327), a nucleic acid synthesis inhibitor, is a very potent and specific deoxycytidine analogue, used as chemotherapy. Gemcitabine induces a potent p53-dependent apoptosis.
Nat Commun, 2021, 12(1):1602
Cancer Res, 2021, canres.1337.2021
Cell Rep, 2021, 34(10):108814
S1782 Azacitidine (5-Azacytidine) Azacitidine (5-Azacytidine, 5-AzaC, Ladakamycin, AZA, 5-Aza, CC-486) is a nucleoside analogue of cytidine that specifically inhibits DNA methylation by trapping DNA methyltransferases. Azacitidine induces mitochondrial apoptosis and autophagy.
Clin Cancer Res, 2021, clincanres.2486.2019
Int J Cancer, 2021, 10.1002/ijc.33865
J Hematol Oncol, 2021, 14(1):70
S2053 Cytidine Cytidine is a nucleoside molecule that is formed when cytosine is attached to a ribose ring, cytidine is a component of RNA.
bioRxiv, 2021, 10.1101/2021.06.28.450163
bioRxiv, 2021, 10.1101/2021.06.28.450163
S2439 Guanosine Guanosine is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond.
Nat Commun, 2020, 11(1):6339
J Med Virol, 2019, 91(8):1440-1447
S3702 Dihydrothymine Dihydrothymine is an intermediate breakdown product of thymine.
Cell Death Differ, 2019, 26(11):2223-2236
S6138 5-Methylcytidine 5-Methylcytidine is a modified nucleoside derived from 5-methylcytosine. It is found in ribonucleic acids of animal, plant, and bacterial origin.
S6854 Triazavirin Triazavirin (TZV, Riamilovir) is a novel antiviral drug, a nucleoside analogue of nucleic acid that inhibits the synthesis of viral RNA and DNA and replication of genomic fragments. Triazavirin is active against influenza and a number of other viruses. Triazavirin is an effective protective agent on the transmission stage of influenza.
S1149 Gemcitabine (LY-188011) HCl Gemcitabine (LY-188011, NSC 613327) HCl is a DNA synthesis inhibitor with IC50 of 50 nM, 40 nM, 18 nM and 12 nM in PANC1, MIAPaCa2, BxPC3 and Capan2 cells, respectively.
Cell, 2021, 184(25):6119-6137.e26
Nat Commun, 2021, 12(1):4917
Nat Commun, 2021, 12(1):1602
S1200 Decitabine (NSC 127716) Decitabine (NSC 127716, Deoxycytidine, Dacogen, 5-aza-2-deoxycytidine, 5-AZA-dC, 5-aza-CdR) is a DNA methyltransferase inhibitor, incorporating into DNA and resulting in hypomethylation of DNA and intra-S-phase arrest of DNA replication. It is used to treat myelodysplastic syndrome (MDS). Decitabine induces cell cycle arrest and apoptosis in various cancer cell lines.
Cancer Cell, 2021, S1535-6108(21)00659-0
Cell Metab, 2021, 33(1):110-127.e5
J Immunother Cancer, 2021, 9(7)e002528
S1209 Fluorouracil (5-Fluorouracil, 5-FU) Fluorouracil (5-Fluorouracil, 5-FU, NSC 19893) is a DNA/RNA synthesis inhibitor, which interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS) in tumor cells. Fluorouracil induces apoptosis and can be used in the treatment of HIV.
Cell, 2021, 184(25):6119-6137.e26
Sci Adv, 2021, 7(36):eabh1684
Nat Commun, 2021, 12(1):4840
S1491 Fludarabine (NSC 118218) Fludarabine (NSC 118218, FaraA, Fludarabinum) is a STAT1 activation inhibitor which causes a specific depletion of STAT1 protein (and mRNA) but not of other STATs. Also a DNA synthesis inhibitor in vascular smooth muscle cells. Fludarabine induces apoptosis.
Cell Metab, 2021, 33(1):110-127.e5
Cell Rep, 2021, 34(1):108584
Cell Rep, 2021, 34(1):108584
S1648 Cytarabine (U-19920A) Cytarabine (U-19920A, Cytarabin, Ara-C, Arabinofuranosyl Cytidine, Cytosine β-D-arabinofuranoside, Cytosine arabinoside, NSC 63878, NSC 287459) is an antimetabolic agent and DNA synthesis inhibitor with IC50 of 16 nM in wild-type CCRF-CEM cells. Cytarabine induces autophagy and apoptosis.
Leukemia, 2021, 10.1038/s41375-021-01361-8
Blood Cancer J, 2021, 11(6):111
Cell Rep, 2021, 36(7):109559
S1807 Aciclovir (BW 248U) Acyclovir (BW 248U, Acyclovir, Acycloguanosine, Zovirax, ACV, NSC 645011) is a synthetic nucleoside analogue active against herpesviruses. Acyclovir induces cell cycle perturbation and apoptosis in Jurkat leukemia cells.
Microbiol Spectr, 2021, 9(3):e0064621
Front Microbiol, 2021, 12:722748
Vet Microbiol, 2021, 265:109313