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Nucleoside Analog/Antimetabolite

Other DNA Damage/DNA Repair Related Inhibitors

HDAC PARP WRN Sirtuin Topoisomerase Telomerase DNA/RNA Synthesis MTH1 DNA alkylator High-mobility Group
Cat.No. Product Name Information Product Use Citations Product Validations
S1200 Decitabine Decitabine is a DNA methyltransferase inhibitor, incorporating into DNA and resulting in hypomethylation of DNA and intra-S-phase arrest of DNA replication. It is used to treat myelodysplastic syndrome (MDS). Decitabine induces cell cycle arrest and apoptosis in various cancer cell lines.
Nucleic Acids Res, 2026, 54(4)gkag089
Sci Rep, 2026, 16(1)14560
Cancer Res Commun, 2026, 6(3):648-656
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S1782 5-Azacytidine (5-Aza, Azacitidine) Azacitidine (5-Azacytidine, 5-AzaC, Ladakamycin, AZA, 5-Aza, CC-486,NSC 102816) is a nucleoside analogue of cytidine that specifically inhibits DNA methylation by trapping DNA methyltransferases. Azacitidine induces mitochondrial apoptosis and autophagy.
Cell Rep Med, 2026, 7(3):102687
Mol Cancer, 2025, 24(1):154
Cell Rep Med, 2025, S2666-3791(25)00102-8
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S1149 Gemcitabine Hydrochloride Gemcitabine is a pyrimidine nucleoside analog antitumor drug that can inhibit DNA synthesis and repair, leading to cell autophagy and apoptosis. It is mainly used to treat various solid tumors such as pancreatic cancer and non-small cell lung cancer, and is often combined with chemotherapy to enhance efficacy.
Oncol Res, 2026, 34(3):12
Cancer Cell, 2025, S1535-6108(25)00271-5
Nat Cell Biol, 2025, 27(6):1021-1034
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S1209 5-Fluorouracil (5-FU) 5-FU (5-Fluorouracil) is a DNA/RNA synthesis inhibitor, which interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS) in tumor cells. Fluorouracil induces apoptosis and can be used in the treatment of HIV.
Adv Sci (Weinh), 2026, 13(19):e11406
Research (Wash D C), 2026, 9:1108
Int J Biol Macromol, 2026, 345:150612
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S1714 Gemcitabine Gemcitabine, a nucleic acid synthesis inhibitor, is a very potent and specific deoxycytidine analogue, used as chemotherapy. Gemcitabine induces a potent p53-dependent apoptosis.
Anticancer Research, October 2022, 4679-4687
Frontiers in Oncology, November 2022, 1021632
Translational Cancer Research, March 2021, 1368-1377
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S1648 Cytarabine Cytarabine is an antimetabolic agent and DNA synthesis inhibitor with IC50 of 16 nM in wild-type CCRF-CEM cells. Cytarabine induces autophagy and apoptosis.
Molecular Cancer Therapeutics, October 05, 2015, 2249–2259
bioRxiv, March 04, 2025, nan
Cancers, June 08, 2023, 3112
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S1491 Fludarabine Fludarabine is a STAT1 activation inhibitor which causes a specific depletion of STAT1 protein (and mRNA) but not of other STATs. Also a DNA synthesis inhibitor in vascular smooth muscle cells. Fludarabine induces apoptosis.
EMBO J, 2026, 45(9):3056-3072
Neurosci Lett, 2026, 875:138543
Cell Mol Immunol, 2025, 22(11):1478-1490
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S2053 Cytidine Cytidine is a nucleoside molecule that is formed when cytosine is attached to a ribose ring, cytidine is a component of RNA.
Nat Commun, 2025, 16(1):4451
Virology, 2025, 610:110598
Cancer Res, 2022, canres.1707.2021
S2439 Guanosine Guanosine is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond.
Nat Commun, 2022, 13(1):5845
Cancer Res, 2022, canres.1707.2021
Nat Commun, 2020, 11(1):6339
E1292 4-Thiouridine 4-thiouridine (4-Thio-UTP), a thiouridine and a nucleoside analogue, has a role as an affinity label and an antimetabolite.
bioRxiv, October 31, 2025, nan
Nature Communications, November 28, 2023, 7794
Nat Commun, 2025, 16(1):9450