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Nucleoside Analog/Antimetabolite
Nucleoside Analog/Antimetabolite Products
- All (15)
- Nucleoside Analog/Antimetabolite Inhibitors (6)
- New Nucleoside Analog/Antimetabolite Products
| Catalog No. | Product Name | Information | Product Use Citations | Product Validations |
|---|---|---|---|---|
| S1714 | Gemcitabine | Gemcitabine, a nucleic acid synthesis inhibitor, is a very potent and specific deoxycytidine analogue, used as chemotherapy. Gemcitabine induces a potent p53-dependent apoptosis. |
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| S1209 | 5-FU (5-Fluorouracil) | 5-FU (5-Fluorouracil) is a DNA/RNA synthesis inhibitor, which interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS) in tumor cells. Fluorouracil induces apoptosis and can be used in the treatment of HIV. |
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| S1200 | Decitabine | Decitabine is a DNA methyltransferase inhibitor, incorporating into DNA and resulting in hypomethylation of DNA and intra-S-phase arrest of DNA replication. It is used to treat myelodysplastic syndrome (MDS). Decitabine induces cell cycle arrest and apoptosis in various cancer cell lines. |
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| S1491 | Fludarabine | Fludarabine is a STAT1 activation inhibitor which causes a specific depletion of STAT1 protein (and mRNA) but not of other STATs. Also a DNA synthesis inhibitor in vascular smooth muscle cells. Fludarabine induces apoptosis. |
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| S1149 | Gemcitabine HCl | Gemcitabine is a pyrimidine nucleoside analog antitumor drug that can inhibit DNA synthesis and repair, leading to cell autophagy and apoptosis. It is mainly used to treat various solid tumors such as pancreatic cancer and non-small cell lung cancer, and is often combined with chemotherapy to enhance efficacy. |
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| S1782 | Azacitidine (5-Azacytidine) | Azacitidine (5-Azacytidine, 5-AzaC, Ladakamycin, AZA, 5-Aza, CC-486,NSC 102816) is a nucleoside analogue of cytidine that specifically inhibits DNA methylation by trapping DNA methyltransferases. Azacitidine induces mitochondrial apoptosis and autophagy. |
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| S1648 | Cytarabine | Cytarabine is an antimetabolic agent and DNA synthesis inhibitor with IC50 of 16 nM in wild-type CCRF-CEM cells. Cytarabine induces autophagy and apoptosis. |
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| S1807 | Acyclovir (Aciclovir) | Acyclovir (Aciclovir) is a synthetic nucleoside analogue active against herpesviruses. Acyclovir induces cell cycle perturbation and apoptosis in Jurkat leukemia cells. |
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| S1647 | Adenosine | Adenosine is a nucleoside composed of a molecule of adenine attached to a ribose sugar molecule (ribofuranose) moiety via a β-N9-glycosidic bond. | ||
| S2053 | Cytidine | Cytidine is a nucleoside molecule that is formed when cytosine is attached to a ribose ring, cytidine is a component of RNA. | ||
| S2439 | Guanosine | Guanosine is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. | ||
| S3702 | Dihydrothymine | Dihydrothymine is an intermediate breakdown product of thymine. | ||
| S6854 | Triazavirin (TZV) | Triazavirin (TZV) is a novel antiviral drug, a nucleoside analogue of nucleic acid that inhibits the synthesis of viral RNA and DNA and replication of genomic fragments. Triazavirin is active against influenza and a number of other viruses. Triazavirin is an effective protective agent on the transmission stage of influenza. | ||
| E2919 | 5-Chloro-2'-deoxyuridine | 5-chloro-2′-deoxyuridine (5-chlorodeoxyuridine; CldU), a thymine analog, is used to study the potential of hypochlorous acid damage to DNA and DNA precursors. | ||
| S6138 | 5-Methylcytidine | 5-Methylcytidine is a modified nucleoside derived from 5-methylcytosine. It is found in ribonucleic acids of animal, plant, and bacterial origin. | ||
| S1209 | 5-FU (5-Fluorouracil) | 5-FU (5-Fluorouracil) is a DNA/RNA synthesis inhibitor, which interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS) in tumor cells. Fluorouracil induces apoptosis and can be used in the treatment of HIV. |
|
|
| S1200 | Decitabine | Decitabine is a DNA methyltransferase inhibitor, incorporating into DNA and resulting in hypomethylation of DNA and intra-S-phase arrest of DNA replication. It is used to treat myelodysplastic syndrome (MDS). Decitabine induces cell cycle arrest and apoptosis in various cancer cell lines. |
|
|
| S1491 | Fludarabine | Fludarabine is a STAT1 activation inhibitor which causes a specific depletion of STAT1 protein (and mRNA) but not of other STATs. Also a DNA synthesis inhibitor in vascular smooth muscle cells. Fludarabine induces apoptosis. |
|
|
| S1149 | Gemcitabine HCl | Gemcitabine is a pyrimidine nucleoside analog antitumor drug that can inhibit DNA synthesis and repair, leading to cell autophagy and apoptosis. It is mainly used to treat various solid tumors such as pancreatic cancer and non-small cell lung cancer, and is often combined with chemotherapy to enhance efficacy. |
|
|
| S1648 | Cytarabine | Cytarabine is an antimetabolic agent and DNA synthesis inhibitor with IC50 of 16 nM in wild-type CCRF-CEM cells. Cytarabine induces autophagy and apoptosis. |
|
|
| S1807 | Acyclovir (Aciclovir) | Acyclovir (Aciclovir) is a synthetic nucleoside analogue active against herpesviruses. Acyclovir induces cell cycle perturbation and apoptosis in Jurkat leukemia cells. |
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Choose Selective Nucleoside Analog/Antimetabolite Inhibitors
Tags: Nucleoside Analog/Antimetabolite inhibitor|Nucleoside Analog/Antimetabolite agonist|Nucleoside Analog/Antimetabolite activator|Nucleoside Analog/Antimetabolite inducer|Nucleoside Analog/Antimetabolite antagonist|Nucleoside Analog/Antimetabolite signaling pathway|Nucleoside Analog/Antimetabolite assay kit
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