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High-mobility Group

DNA Damage/DNA Repair

GluR GABA Receptor AMPA Receptor-kainate Receptor-NMDA Receptor Gamma-secretase Dopamine Receptor 5-HT Receptor P2 Receptor AChR MAO Beta Amyloid Substance P BACE CaMK NMDAR GlyT Neurotrophin Notch BChE Adenosine Kinase Adenosine Deaminase Neurotensin Receptor Serotonin Transporter Secretase Calcineurin Ion Channel AAK1 Anion Exchanger Cholinesterase (ChE) Glutaminyl Cyclase HCN Channel iGluR Norepinephrine Amyloid-β

Isoform-selective Products

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  • High-mobility Group Inhibitors (2)
  • New High-mobility Group Products
Cat.No. Product Name Information Product Use Citations Product Validations
S2302 Glycyrrhizin (NSC 167409) Glycyrrhizin (NSC 167409, Glycyrrhizic Acid) is a direct HMGB1(high mobility group box 1) inhibitor that inhibits HMGB1-dependent inflammatory molecule expression and oxidative stress; modulates P38 and P-JNK but not p-ERK signalling; Also inhibits 11 beta-hydroxysteroid dehydrogenase and monoamine oxidase (MAO).
Nat Commun, 2025, 16(1):2513
Chin Med J (Engl), 2025, 138(1):79-92
Oncol Rep, 2025, 54(3)106
Verified customer review of Glycyrrhizin (NSC 167409)
S2376 Ammonium Glycyrrhizinate Ammonium Glycyrrhizinate (AMGZ, Glycyram, Glycyrrhizin ammonium salt, Glycyrrhizic acid ammonium salt) is a unique product from Licorice root with a very high sweetness. This compound is a direct inhibitor of HMGB1 with anti-inflammatory, anti-tumor, anti-diabetic activities. It inhibits growth and cytopathology of several unrelated DNA and RNA viruses. This chemical also inhibits both hepatic delta 4-5-reductase and 11 beta-hydroxysteroid dehydrogenase.
Nat Commun, 2025, 16(1):2513
Eur J Pharmacol, 2024, 962:176171
Pharmacol Res, 2023, 192:106791
S2302 Glycyrrhizin (NSC 167409) Glycyrrhizin (NSC 167409, Glycyrrhizic Acid) is a direct HMGB1(high mobility group box 1) inhibitor that inhibits HMGB1-dependent inflammatory molecule expression and oxidative stress; modulates P38 and P-JNK but not p-ERK signalling; Also inhibits 11 beta-hydroxysteroid dehydrogenase and monoamine oxidase (MAO).
Nat Commun, 2025, 16(1):2513
Chin Med J (Engl), 2025, 138(1):79-92
Oncol Rep, 2025, 54(3)106
 Verified customer review of Glycyrrhizin (NSC 167409)
S2376 Ammonium Glycyrrhizinate Ammonium Glycyrrhizinate (AMGZ, Glycyram, Glycyrrhizin ammonium salt, Glycyrrhizic acid ammonium salt) is a unique product from Licorice root with a very high sweetness. This compound is a direct inhibitor of HMGB1 with anti-inflammatory, anti-tumor, anti-diabetic activities. It inhibits growth and cytopathology of several unrelated DNA and RNA viruses. This chemical also inhibits both hepatic delta 4-5-reductase and 11 beta-hydroxysteroid dehydrogenase.
Nat Commun, 2025, 16(1):2513
Eur J Pharmacol, 2024, 962:176171
Pharmacol Res, 2023, 192:106791