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FENs

Isoform-selective Products

hFEN1

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FENs Inhibitors (2)
New FENs Products

Catalog No.	Product Name	Information	Product Use Citations	Product Validations
S3397	FEN1-IN-4	FEN1-IN-4 (FEN1 Inhibitor C2, JUN93587, Compound 2) is an inhibitor of human flap endonuclease-1 (hFEN1) with IC50 of 30 nM for hFEN1-336Δ.	Sci Adv, 2025, 11(2):eads2919 Cell Rep, 2024, 43(8):114522 Int J Mol Sci, 2024, 25(4)2110
E5886^New	FEN1-IN-1	FEN1-IN-1 (Compound 1) is an inhibitor of Flap endonuclease 1 (FEN1), binding to its active site and inhibiting activity partly by coordinating with Mg²⁺ ions. By blocking FEN1, it initiates a DNA damage response, activating the ATM checkpoint pathway, histone H2AX phosphorylation, and FANCD2 ubiquitination in mammalian cells.
S3397	FEN1-IN-4	FEN1-IN-4 (FEN1 Inhibitor C2, JUN93587, Compound 2) is an inhibitor of human flap endonuclease-1 (hFEN1) with IC50 of 30 nM for hFEN1-336Δ.	Sci Adv, 2025, 11(2):eads2919 Cell Rep, 2024, 43(8):114522 Int J Mol Sci, 2024, 25(4)2110
E5886^New	FEN1-IN-1	FEN1-IN-1 (Compound 1) is an inhibitor of Flap endonuclease 1 (FEN1), binding to its active site and inhibiting activity partly by coordinating with Mg²⁺ ions. By blocking FEN1, it initiates a DNA damage response, activating the ATM checkpoint pathway, histone H2AX phosphorylation, and FANCD2 ubiquitination in mammalian cells.
E5886^New	FEN1-IN-1	FEN1-IN-1 (Compound 1) is an inhibitor of Flap endonuclease 1 (FEN1), binding to its active site and inhibiting activity partly by coordinating with Mg²⁺ ions. By blocking FEN1, it initiates a DNA damage response, activating the ATM checkpoint pathway, histone H2AX phosphorylation, and FANCD2 ubiquitination in mammalian cells.

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