FENs antagonist | FENs inhibitor | FENs agonist

Other DNA Damage/DNA Repair Related Inhibitors

HDAC PARP WRN Sirtuin Topoisomerase Telomerase DNA/RNA Synthesis MTH1 DNA alkylator High-mobility Group

Isoform-selective Products

hFEN1

Cat.No.	Product Name	Information	Product Use Citations	Product Validations
S3397	FEN1-IN-4	FEN1-IN-4 (FEN1 Inhibitor C2, JUN93587, Compound 2) is an inhibitor of human flap endonuclease-1 (hFEN1) with IC50 of 30 nM for hFEN1-336Δ.	Sci Adv, 2025, 11(2):eads2919 Cell Rep, 2024, 43(8):114522 Int J Mol Sci, 2024, 25(4)2110
E5886^New	FEN1-IN-1	FEN1-IN-1 (Compound 1) is an inhibitor of Flap endonuclease 1 (FEN1), binding to its active site and inhibiting activity partly by coordinating with Mg²⁺ ions. By blocking FEN1, it initiates a DNA damage response, activating the ATM checkpoint pathway, histone H2AX phosphorylation, and FANCD2 ubiquitination in mammalian cells.

Cat.No.

Product Name

Information

Product Use Citations

Product Validations

S3397

FEN1-IN-4

FEN1-IN-4 (FEN1 Inhibitor C2, JUN93587, Compound 2) is an inhibitor of human flap endonuclease-1 (hFEN1) with IC50 of 30 nM for hFEN1-336Δ.

Sci Adv, 2025, 11(2):eads2919

Cell Rep, 2024, 43(8):114522

Int J Mol Sci, 2024, 25(4)2110

E5886^New

FEN1-IN-1

FEN1-IN-1 (Compound 1) is an inhibitor of Flap endonuclease 1 (FEN1), binding to its active site and inhibiting activity partly by coordinating with Mg²⁺ ions. By blocking FEN1, it initiates a DNA damage response, activating the ATM checkpoint pathway, histone H2AX phosphorylation, and FANCD2 ubiquitination in mammalian cells.