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DNA/RNA Synthesis Inhibitors

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Isoform-selective Products

Cat.No. Product Name Information Product Use Citations Product Validations
S1237 TMZ(Temozolomide) Temozolomide (TMZ) is a monofunctional SN-1 alkylating agent that can modify nitrogen atoms in the DNA ring and the extracyclic oxygen group, chemically converted to MTIC and degrades to methyldiazonium cation, which transfers methyl groups to DNA at physiologic pH. It is a DNA damage inducer in L-1210 and L-1210/BCNU cells. This compound induces apoptosis and exhibits antitumor activity.
Cancer Cell, 2025, S1535-6108(25)00223-5
Cancer Cell, 2025, 43(4):776-796.e14
Nat Commun, 2025, 16(1):5676
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S1166 Cisplatin Cisplatin is an inorganic platinum complex, which is able to inhibit DNA synthesis by conforming DNA adducts in tumor cells. Cisplatin activates ferroptosis and induces autophagy.Solutions are unstable and should be fresh-prepared.DMSO is not recommended to dissolve platinum-based drugs, which can easily lead to drug inactivation.
Cell, 2025, S0092-8674(25)00291-0
Cancer Cell, 2025, S1535-6108(25)00223-5
Cell Stem Cell, 2025, S1934-5909(25)00265-6
Verified customer review of Cisplatin
S2684 CX-5461 (Pidnarulex) CX-5461 (Pidnarulex) is an inhibitor of rRNA synthesis that selectively inhibits Pol I-driven transcription of rRNA with an IC50 of 142 nM in HCT-116, A375, and MIA PaCa-2 cells. It has no effect on Pol II and possesses 250- to 300-fold selectivity for inhibition of rRNA transcription versus DNA replication and protein translation.
Nat Commun, 2025, 16(1):2641
Nat Commun, 2025, 16(1):1676
Nucleic Acids Res, 2025, 53(18)gkaf939
Verified customer review of CX-5461 (Pidnarulex)
S1214 Bleomycin sulfate Bleomycin sulfate is a glycopeptide antibiotic and a DNA synthesis inhibitor, as well as an anticancer agent for squamous cell carcinomas (SCC) with an IC50 of 4 nM in UT-SCC-19A cells. Bleomycin sulfate is a DNA synthesis inhibitor. Bleomycin (NSC125066) sulfate can be used to induce animal models of pulmonary fibrosis.
Nat Cell Biol, 2025, 10.1038/s41556-025-01648-3
Nat Commun, 2025, 16(1):1826
Nat Commun, 2025, 16(1):9183
Verified customer review of Bleomycin sulfate
S1149 Gemcitabine Hydrochloride Gemcitabine is a pyrimidine nucleoside analog antitumor drug that can inhibit DNA synthesis and repair, leading to cell autophagy and apoptosis. It is mainly used to treat various solid tumors such as pancreatic cancer and non-small cell lung cancer, and is often combined with chemotherapy to enhance efficacy.
Cancer Cell, 2025, S1535-6108(25)00271-5
Nat Cell Biol, 2025, 27(6):1021-1034
Trends Biotechnol, 2025, S0167-7799(25)00406-8
Verified customer review of Gemcitabine Hydrochloride
S1209 5-Fluorouracil (5-FU) 5-FU (5-Fluorouracil) is a DNA/RNA synthesis inhibitor, which interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS) in tumor cells. Fluorouracil induces apoptosis and can be used in the treatment of HIV.
Nature, 2025, 10.1038/s41586-025-08974-4
Cancer Cell, 2025, S1535-6108(25)00223-5
Cell Stem Cell, 2025, S1934-5909(25)00265-6
Verified customer review of 5-Fluorouracil (5-FU)
S1213 Nelarabine Nelarabine (506U78,Arranon) is a purine nucleoside analog and DNA synthesis inhibitor with IC50 from 0.067-2.15 μM in tumor cells.
Communications Medicine, 2025, 420
iScience, 2024, 27(10):110862
Cancer Res, 2022, 82(4):721-733
Verified customer review of Nelarabine
S1224 Oxaliplatin Oxaliplatin is a DNA alkylating agent that activates autophagy. Oxaliplatin inhibits DNA synthesis by conforming DNA adducts in RT4, TCCSUP, A2780, HT-29, U-373MG, U-87MG, SK-MEL-2, and HT-144 cells.Solutions are unstable and should be fresh-prepared.DMSO is not recommended to dissolve platinum-based drugs, which can easily lead to drug inactivation.
Nature, 2025, 10.1038/s41586-025-08974-4
Cancer Cell, 2025, S1535-6108(25)00223-5
Signal Transduct Target Ther, 2025, 10(1):341
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S1714 Gemcitabine Gemcitabine, a nucleic acid synthesis inhibitor, is a very potent and specific deoxycytidine analogue, used as chemotherapy. Gemcitabine induces a potent p53-dependent apoptosis.
Nature, 2025, 10.1038/s41586-025-08974-4
Cell, 2025, S0092-8674(25)00556-2
Cancer Cell, 2025, 43(8):1530-1548.e9
Verified customer review of Gemcitabine
S1229 Fludarabine (NSC 118218) Phosphate Fludarabine Phosphate is an analogue of adenosine and deoxyadenosine, which is able to compete with dATP for incorporation into DNA and inhibit DNA synthesis.
Cell Death Differ, 2025, 10.1038/s41418-025-01585-6
J Autoimmun, 2024, 149:103307
Cell Death Dis, 2024, 15(3):224
Verified customer review of Fludarabine (NSC 118218) Phosphate

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