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DNA/RNA Synthesis inhibitors

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Isoform-selective Products

Cat.No. Product Name Information Product Use Citations Product Validations
S1166 Cisplatin Cisplatin is an inorganic platinum complex, which is able to inhibit DNA synthesis by conforming DNA adducts in tumor cells. Cisplatin activates ferroptosis and induces autophagy.Solutions are unstable and should be fresh-prepared.DMSO is not recommended to dissolve platinum-based drugs, which can easily lead to drug inactivation.
Cell, 2025, S0092-8674(25)00291-0
Cancer Cell, 2025, S1535-6108(25)00223-5
Cell Stem Cell, 2025, S1934-5909(25)00265-6
Verified customer review of Cisplatin
S1714 Gemcitabine Gemcitabine, a nucleic acid synthesis inhibitor, is a very potent and specific deoxycytidine analogue, used as chemotherapy. Gemcitabine induces a potent p53-dependent apoptosis.
Nature, 2025, 10.1038/s41586-025-08974-4
Cell, 2025, S0092-8674(25)00556-2
Cancer Cell, 2025, 43(8):1530-1548.e9
Verified customer review of Gemcitabine
S1209 5-Fluorouracil (5-FU) 5-FU (5-Fluorouracil) is a DNA/RNA synthesis inhibitor, which interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS) in tumor cells. Fluorouracil induces apoptosis and can be used in the treatment of HIV.
Nature, 2025, 10.1038/s41586-025-08974-4
Cancer Cell, 2025, S1535-6108(25)00223-5
Cell Stem Cell, 2025, S1934-5909(25)00265-6
Verified customer review of 5-Fluorouracil (5-FU)
S1224 Oxaliplatin Oxaliplatin is a DNA alkylating agent that activates autophagy. Oxaliplatin inhibits DNA synthesis by conforming DNA adducts in RT4, TCCSUP, A2780, HT-29, U-373MG, U-87MG, SK-MEL-2, and HT-144 cells.Solutions are unstable and should be fresh-prepared.DMSO is not recommended to dissolve platinum-based drugs, which can easily lead to drug inactivation.
Nature, 2025, 10.1038/s41586-025-08974-4
Cancer Cell, 2025, S1535-6108(25)00223-5
Signal Transduct Target Ther, 2025, 10(1):341
Verified customer review of Oxaliplatin
S1237 TMZ(Temozolomide) Temozolomide (TMZ) is a monofunctional SN-1 alkylating agent that can modify nitrogen atoms in the DNA ring and the extracyclic oxygen group, chemically converted to MTIC and degrades to methyldiazonium cation, which transfers methyl groups to DNA at physiologic pH. It is a DNA damage inducer in L-1210 and L-1210/BCNU cells. This compound induces apoptosis and exhibits antitumor activity.
Cancer Cell, 2025, S1535-6108(25)00223-5
Cancer Cell, 2025, 43(4):776-796.e14
Nat Commun, 2025, 16(1):5676
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S1149 Gemcitabine Hydrochloride Gemcitabine is a pyrimidine nucleoside analog antitumor drug that can inhibit DNA synthesis and repair, leading to cell autophagy and apoptosis. It is mainly used to treat various solid tumors such as pancreatic cancer and non-small cell lung cancer, and is often combined with chemotherapy to enhance efficacy.
Cancer Cell, 2025, S1535-6108(25)00271-5
Nat Cell Biol, 2025, 27(6):1021-1034
Trends Biotechnol, 2025, S0167-7799(25)00406-8
Verified customer review of Gemcitabine Hydrochloride
S1214 Bleomycin sulfate Bleomycin sulfate is a glycopeptide antibiotic and a DNA synthesis inhibitor, as well as an anticancer agent for squamous cell carcinomas (SCC) with an IC50 of 4 nM in UT-SCC-19A cells. Bleomycin sulfate is a DNA synthesis inhibitor. Bleomycin (NSC125066) sulfate can be used to induce animal models of pulmonary fibrosis.
Nat Cell Biol, 2025, 10.1038/s41556-025-01648-3
Nat Commun, 2025, 16(1):1826
Nat Commun, 2025, 16(1):9183
Verified customer review of Bleomycin sulfate
S1648 Cytarabine Cytarabine is an antimetabolic agent and DNA synthesis inhibitor with IC50 of 16 nM in wild-type CCRF-CEM cells. Cytarabine induces autophagy and apoptosis.
Nat Commun, 2025, 16(1):4133
Acta Pharm Sin B, 2025, 15(10):5277-5293
Cell Death Dis, 2025, 16(1):601
Verified customer review of Cytarabine
S2684 CX-5461 (Pidnarulex) CX-5461 (Pidnarulex) is an inhibitor of rRNA synthesis that selectively inhibits Pol I-driven transcription of rRNA with an IC50 of 142 nM in HCT-116, A375, and MIA PaCa-2 cells. It has no effect on Pol II and possesses 250- to 300-fold selectivity for inhibition of rRNA transcription versus DNA replication and protein translation.
Nat Commun, 2025, 16(1):2641
Nat Commun, 2025, 16(1):1676
Nucleic Acids Res, 2025, 53(18)gkaf939
Verified customer review of CX-5461 (Pidnarulex)
S1229 Fludarabine (NSC 118218) Phosphate Fludarabine Phosphate is an analogue of adenosine and deoxyadenosine, which is able to compete with dATP for incorporation into DNA and inhibit DNA synthesis.
Cell Death Differ, 2025, 10.1038/s41418-025-01585-6
J Autoimmun, 2024, 149:103307
Cell Death Dis, 2024, 15(3):224
Verified customer review of Fludarabine (NSC 118218) Phosphate
S1896 Hydroxyurea Hydroxyurea is an antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase. Hydroxyurea activates apoptosis and autophagy. Hydroxyurea is used to treat HIV infection.
J Exp Med, 2025, 222(3)e20241248
Antimicrob Agents Chemother, 2025, e0047125.
Invest Ophthalmol Vis Sci, 2025, 66(5):42
Verified customer review of Hydroxyurea
S8434 B02 B02 is a small-molecule inhibitor of human RAD51 with an IC50 of 27.4 μM, but this compound does not inhibit its E. coli homologue RecA (IC50 > 250 μM).
Nucleic Acids Res, 2025, 53(18)gkaf961
NPJ Precis Oncol, 2025, 9(1):20
Clin Epigenetics, 2025, 17(1):20
Verified customer review of B02
S1213 Nelarabine Nelarabine (506U78,Arranon) is a purine nucleoside analog and DNA synthesis inhibitor with IC50 from 0.067-2.15 μM in tumor cells.
iScience, 2024, 27(10):110862
Cancer Res, 2022, 82(4):721-733
Cell Rep, 2022, 39(10):110913
Verified customer review of Nelarabine
S4227 Fidaxomicin Fidaxomicin is a narrow spectrum macrocyclic antibiotic that inhibits RNA polymerase sigma subunit.
J Antimicrob Chemother, 2024, dkae101
Nucleic Acids Res, 2023, 51(19):e99
bioRxiv, 2023, 2023.03.13.532464
S1217 Cyclophosphamide Cyclophosphamide(NSC 26271,Endoxan, Cytoxan, Neosar, Procytox, Revimmune, Cytophosphane) is a nitrogen mustard alkylating agent from the oxazophorines group.
Neurotherapeutics, 2025, 22(1):e00480
Sci Rep, 2025, 15(1):2893
Front Biosci (Landmark Ed), 2025, 30(11):45744
Verified customer review of Cyclophosphamide
S7418 Cycloheximide Cycloheximide, an antifungal antibiotic, is an eukaryote protein synthesis inhibitor with IC50 of 532.5 nM and 2880 nM for protein synthesis and RNA synthesis in vivo, respectively. Cycloheximide suppresses ferroptosis and inhibits autophagy.Cycloheximide (NSC-185) can be used to induce animal models of Dysmnesia.Solutions are unstable and should be fresh-prepared.This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing.
Cancer Cell, 2025, S1535-6108(25)00070-4
Signal Transduct Target Ther, 2025, 10(1):81
Signal Transduct Target Ther, 2025, 10(1):26
S1491 Fludarabine Fludarabine is a STAT1 activation inhibitor which causes a specific depletion of STAT1 protein (and mRNA) but not of other STATs. Also a DNA synthesis inhibitor in vascular smooth muscle cells. Fludarabine induces apoptosis.
Cell Mol Immunol, 2025, 22(11):1478-1490
J Immunother Cancer, 2025, 13(7)e010926
Cell Rep, 2025, 44(4):115559
Verified customer review of Fludarabine
S1215 Carboplatin Carboplatin, a derivative of CDDP, is a DNA synthesis inhibitor which binds to DNA, inhibits replication and transcription and induces cell death and interfers with the cell's repair mechanism in A2780, SKOV-3, IGROV-1, and HX62 cells. It induces the formation of DNA interstrand crosslinks and DNA-protein crosslinks. Solutions are unstable and should be fresh-prepared.DMSO is not recommended to dissolve platinum-based drugs, which can easily lead to drug inactivation.
Nat Commun, 2025, 16(1):8932
Cell Rep Med, 2025, 6(6):102160
Cancer Res, 2025, 10.1158/0008-5472.CAN-24-2360
Verified customer review of Carboplatin
S8146 Mitomycin C Mitomycin C (Ametycine) is an antineoplastic antibiotic by inhibiting DNA synthesis, used to treat different cancers. Mitomycin C induces apoptosis in a caspases-dependent and Fas/CD95-independent manner.This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing.
Cell, 2025, S0092-8674(25)00625-7
Biomaterials, 2025, 317:123090
EMBO J, 2025, 44(14):4013-4036
Verified customer review of Mitomycin C
S8964 Actinomycin D (Dactinomycin) Actinomycin D (Dactinomycin, Act D, RASP-101) is a significant polypeptide antibiotic isolated from soil bacteria of the genus Streptomyces. Actinomycin D (Dactinomycin) inhibits DNA repair and rests the cell cycle at G1 phase with IC50 of 0.42 μM and 0.4 nM, respectively. Actinomycin D is an RNA and protein synthesis inhibitor that can suppress bacterial protein synthesis. Actinomycin D is an autophagy activator, induces p53-independent cell death and prolongs survival in high-risk chronic lymphocytic leukemia.This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing.
Signal Transduct Target Ther, 2025, 10(1):236
Mol Cancer, 2025, 24(1):217
Nat Plants, 2025, 11(11):2300-2318
S9936 ART558 ART558 is a potent, selective, low molecular weight, allosteric inhibitor of DNA Polθ with an IC50 of 7.9 nM.
Leukemia, 2025, 39(9):2152-2162
E1939 ART899 ART899, a derivative of ART558 is a potent, specific allosteric inhibitor of DNA polymerase theta (Polθ), specifically inhibits Polθ MMEJ activity with IC50 of 180 nM. It specifically radiosensitizes tumor cells and have a potent stand-alone antitumor effect in cancer cells.

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