COX (Cyclooxygenase), which is also called prostaglandin-endoperoxide synthase, plays the rate-limiting role in the process of converting arachidonic acid to prostaglandins and thromboxane. Cyclooxygenase is the molecular target for aspirin and NSAIDs(non-steroidal antiinflammatory drugs). COX contains 3 isoenzymes which are called COX-1, COX2, and COX3.
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Austria
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Brazil
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China
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Finland
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Israel
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COX inhibitors
Other Immunology & Inflammation Related Inhibitors
| Cat.No. | Product Name | Information | Product Use Citations | Product Validations |
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| S1396 | Resveratrol (trans-Resveratrol) | Resveratrol has a wide spectrum of targets including cyclooxygenases(i.e. COX, IC50=1.1 μM), lipooxygenases（LOX, IC50=2.7 μM）, kinases, sirtuins and other proteins. It has anti-cancer, anti-inflammatory, blood-sugar-lowering and other beneficial cardiovascular effects. Resveratrol induces mitophagy/autophagy and autophagy-dependent apoptosis. |
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| S1261 | Celecoxib (SC-58635) | Celecoxib is a selective COX-2 inhibitor with IC50 of 40 nM in Sf9 cells. |
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| S3017 | Aspirin | Aspirin is a salicylate, and irreversible COX1 and COX2 inhibitor, used as an analgesic to relieve minor aches and pains, as an antipyretic to reduce fever, and as an anti-inflammatory medication. This compound induces autophagy and stimulates mitophagy. |
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| S1723 | Indomethacin | Indomethacin is a nonselective COX1 and COX2 inhibitor with IC50 of 0.1 μg/mL and 5 μg/mL, respectively, used to reduce fever, pain, stiffness, and swelling. |
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| S8433 | NS-398 (NS398) | NS-398 (N-(2-cyclohexyloxy-4-nitrophenyl)methane sulfonamide) is a selective inhibitor of cyclooxygenase-2 (COX-2), with IC50 values for human recombinant COX-1 and -2 of 75 and 1.77 μM, respectively. |
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| S4686 | Vitamin E | Vitamin E (D-alpha-Tocopherol) is a fat-soluble vitamin with potent antioxidant properties. It is a potent peroxyl radical scavenger and inhibits noncompetitively cyclooxygenase activity in many tissues, also inhibits angiogenesis and tumor dormancy through suppressing vascular endothelial growth factor (VEGF) gene transcription. |
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| S2007 | Sulindac | Sulindac(MK-231) is a non-steroidal COX inhibitor, which potently inhibits prostaglandin synthesis, used in the treatment of acute or chronic inflammatory conditions. |
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| S2410 | Paeoniflorin (NSC 178886) | Paeoniflorin (NSC 178886, Peoniflorin), a herbal constituent extracted from the root of Paeonia albiflora Pall, reduces COX-2 expression. It alleviates liver fibrosis by inhibiting HIF-1α through mTOR-dependent pathway. |
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| S7889 | Xanthohumol | Xanthohumol, a prenylated chalcone from hop, inhibits COX-1 and COX-2 activity and shows chemopreventive effects. This compound inhibits diacylglycerol acyltransferase 1 (DGAT1) and DGAT2 with both IC50 of 40 μM. It is also a potent antiviral agent against a series of DNA and RNA viruses. This chemical induces growth inhibition and apoptosis in cancer cells. Phase 1. |
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| S2903 | Lumiracoxib | Lumiracoxib (COX-189) is a novel, selective COX-2 inhibitor with Ki of 0.06 μM. This compound also inhibits COX1 with Ki of 3 μM. |
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Signaling Pathway Map
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