For research use only.
CAS No. 78213-16-8
Diclofenac diethylamine is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions. Diclofenac exerts its action via inhibition of prostaglandin synthesis by inhibiting cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) with relative equipotency.
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|Description||Diclofenac diethylamine is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions. Diclofenac exerts its action via inhibition of prostaglandin synthesis by inhibiting cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) with relative equipotency.|
The primary mechanism of diclofenac diethylamine responsible for its anti-inflammatory, antipyretic, and analgesic action is thought to be inhibition of prostaglandin synthesis by inhibition of cyclooxygenase (COX). It also appears to exhibit bacteriostatic activity by inhibiting bacterial DNA synthesis. Inhibition of COX also decreases prostaglandins in the epithelium of the stomach, making it more sensitive to corrosion by gastric acid. This is also the main side effect of diclofenac. Diclofenac diethylamine has a low to moderate preference to block the COX2-isoenzyme (approximately 10-fold) and is said to have, therefore, a somewhat lower incidence of gastrointestinal complaints than noted with indomethacin and aspirin.
|In vitro||DMSO||74 mg/mL (200.38 mM)|
|Ethanol||74 mg/mL (200.38 mM)|
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT03150732||Not yet recruiting||Drug: Systemic nalbuphine|Drug: Local nalbuphine||Postoperative Pain||Assiut University||December 10 2021||Not Applicable|
|NCT05026320||Recruiting||Drug: Naproxen gel|Drug: Diclofenac gel|Drug: Placebo gel||Soft Tissue Injury||Bayer|Deutsche Sporthochschule Köln||August 8 2021||Phase 2|
|NCT04530903||Recruiting||Drug: Clonidine|Drug: Levobupivacaine|Drug: NaCl 0.9%||Proctological Surgery||Centre Hospitalier Universitaire Saint Pierre||September 9 2020||Phase 4|
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