For research use only.

Catalog No.S4656 Synonyms: SC-69124, Valus-P, Vorth-P

1 publication

Parecoxib Chemical Structure

CAS No. 198470-84-7

Parecoxib (SC-69124, Valus-P, Vorth-P) is a selective COX2 inhibitor.

Selleck's Parecoxib has been cited by 1 publication

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Biological Activity

Description Parecoxib (SC-69124, Valus-P, Vorth-P) is a selective COX2 inhibitor.
COX2 [1]
In vivo Parecoxib, a selected cyclooxygenase-2 inhibitor, ameliorates neurologic deficits in the behavior studies and brain damage, including neuronal death, and brain edema in the MCP-1 and NeuN immunostaining in rats subjected to SAH(Subarachnoid Hemorrhage). Parecoxib is able to reduce early COX2 expression via inhibiting cJNK (p55) expression (dose-dependently), reduce IL-1β, IL-6 and MCP-1( at 2000 ug/kg/day at the time point of 24hr and 72hr after the induction of SAH), IL-8 (of the dosage of 2000 ug/kg/day at 24hr after the induction of SAH), and also reduce cleaved caspase-1 (at 1000 and 2000 ug/kg/day) and Caspase-9a (at 2000 ug/kg/day). Parecoxib reduces the NMDAR-1, and NMDAR-2a (at 1000 and 2000 ug/kg) after the induction of SAH[2].


Animal Research:


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  • Animal Models: Female Sprague-Dawley rats
  • Dosages: 0.3, 1.5, 6.4 mg/kg
  • Administration: i.m.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 74 mg/mL (199.77 mM)
Ethanol 2 mg/mL (5.39 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 370.42


CAS No. 198470-84-7
Storage powder
in solvent
Synonyms SC-69124, Valus-P, Vorth-P
Smiles CCC(=O)NS(=O)(=O)C1=CC=C(C=C1)C2=C(ON=C2C3=CC=CC=C3)C

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