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Parecoxib COX inhibitor

Cat.No.S4656

Parecoxib (SC-69124, Valus-P, Vorth-P) is a selective COX2 inhibitor.
Parecoxib COX inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 370.42

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Quality Control

Batch: S465601 DMSO]74 mg/mL]false]Ethanol]2 mg/mL]false]Water]Insoluble]false Purity: 99.77%
99.77

Solubility

In vitro
Batch:

DMSO : 74 mg/mL (199.77 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 2 mg/mL

Water : Insoluble

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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Chemical Information, Storage & Stability

Molecular Weight 370.42 Formula

C19H18N2O4S

 Storage (From the date of receipt)
CAS No. 198470-84-7 Download SDF Storage of Stock Solutions

Synonyms SC-69124, Valus-P, Vorth-P Smiles CCC(=O)NS(=O)(=O)C1=CC=C(C=C1)C2=C(ON=C2C3=CC=CC=C3)C

Mechanism of Action

Targets/IC50/Ki
COX2
In vivo
Parecoxib, a selected cyclooxygenase-2 inhibitor, ameliorates neurologic deficits in the behavior studies and brain damage, including neuronal death, and brain edema in the MCP-1 and NeuN immunostaining in rats subjected to SAH(Subarachnoid Hemorrhage). This compound is able to reduce early COX2 expression via inhibiting cJNK (p55) expression (dose-dependently), reduce IL-1β, IL-6 and MCP-1( at 2000 ug/kg/day at the time point of 24hr and 72hr after the induction of SAH), IL-8 (of the dosage of 2000 ug/kg/day at 24hr after the induction of SAH), and also reduce cleaved caspase-1 (at 1000 and 2000 ug/kg/day) and Caspase-9a (at 2000 ug/kg/day). It reduces the NMDAR-1, and NMDAR-2a (at 1000 and 2000 ug/kg) after the induction of SAH.
References
  • [1] https://pubmed.ncbi.nlm.nih.gov/16810556/
  • [2] http://www.omicsonline.org/open-access/parecoxib-a-selective-cyclooxygenase-inhibitor-attenuates-cjun-nterminalkinase-activation-in-experimental-subarachnoid-hemorrhage-induced-earlybrain-injury-2155-9562-1000294.php?aid=55129

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