Catalog No.S4656 Synonyms: SC-69124, Valus-P, Vorth-P

For research use only.

Parecoxib (SC-69124, Valus-P, Vorth-P) is a selective COX2 inhibitor.

Parecoxib Chemical Structure

CAS No. 198470-84-7

Selleck's Parecoxib has been cited by 1 Publication

Purity & Quality Control

Choose Selective COX Inhibitors

Other COX Products

Biological Activity

Description Parecoxib (SC-69124, Valus-P, Vorth-P) is a selective COX2 inhibitor.
COX2 [1]
In vivo Parecoxib, a selected cyclooxygenase-2 inhibitor, ameliorates neurologic deficits in the behavior studies and brain damage, including neuronal death, and brain edema in the MCP-1 and NeuN immunostaining in rats subjected to SAH(Subarachnoid Hemorrhage). Parecoxib is able to reduce early COX2 expression via inhibiting cJNK (p55) expression (dose-dependently), reduce IL-1β, IL-6 and MCP-1( at 2000 ug/kg/day at the time point of 24hr and 72hr after the induction of SAH), IL-8 (of the dosage of 2000 ug/kg/day at 24hr after the induction of SAH), and also reduce cleaved caspase-1 (at 1000 and 2000 ug/kg/day) and Caspase-9a (at 2000 ug/kg/day). Parecoxib reduces the NMDAR-1, and NMDAR-2a (at 1000 and 2000 ug/kg) after the induction of SAH[2].

Protocol (from reference)

Animal Research:


  • Animal Models: Female Sprague-Dawley rats
  • Dosages: 0.3, 1.5, 6.4 mg/kg
  • Administration: i.m.

Solubility (25°C)

In vitro

DMSO 74 mg/mL
(199.77 mM)
Ethanol 2 mg/mL
(5.39 mM)
Water Insoluble

Chemical Information

Molecular Weight 370.42


CAS No. 198470-84-7
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CCC(=O)NS(=O)(=O)C1=CC=C(C=C1)C2=C(ON=C2C3=CC=CC=C3)C

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Parecoxib | Parecoxib supplier | purchase Parecoxib | Parecoxib cost | Parecoxib manufacturer | order Parecoxib | Parecoxib distributor