Home Immunology & Inflammation COX inhibitor FK-3311

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FK-3311 COX inhibitor

Cat.No.S2595

FK-3311 (COX-2 Inhibitor V) is a selective, cell-permeable and orally available inhibitor of cyclooxygenase-2 (COX-2) with antiinflammatory. This compound has protective effects against hepatic warm ischemia-reperfusion injury by marked inhibition of TxA2.
FK-3311 COX inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 341.33

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability Specificity

Quality Control

Batch: S259501 DMSO]68 mg/mL]false]Ethanol]8 mg/mL]false]Water]Insoluble]false Purity: 98.69%
98.69

Chemical Information, Storage & Stability

Molecular Weight 341.33 Formula

C15H13F2NO4S

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 116686-15-8 -- Storage of Stock Solutions

Synonyms COX-2 Inhibitor V Smiles CC(=O)C1=CC(=C(C=C1)NS(=O)(=O)C)OC2=C(C=C(C=C2)F)F

Solubility

In vitro
Batch:

DMSO : 68 mg/mL ( (199.22 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 8 mg/mL

Water : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Targets/IC50/Ki
COX-2 [1]
TxA2 [1]
References

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