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Pranoprofen COX inhibitor

Cat.No.S1960

Pranoprofen (Pyranoprofen,Pranopulin) is a non-steroidal COX inhibitor, used as an anti-inflammatory drug in ophthalmology.
Pranoprofen COX inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 255.27

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Quality Control

Batch: Purity: 99.47%
99.47

Solubility

In vitro
Batch:

DMSO : 51 mg/mL (199.78 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 51 mg/mL

Water : Insoluble

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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Chemical Information, Storage & Stability

Molecular Weight 255.27 Formula

C15H13NO3

 Storage (From the date of receipt)
CAS No. 52549-17-4 Download SDF Storage of Stock Solutions

Synonyms Pyranoprofen,Pranopulin Smiles CC(C1=CC2=C(C=C1)OC3=C(C2)C=CC=N3)C(=O)O

Mechanism of Action

Targets/IC50/Ki
COX
In vitro

Pranoprofen inhibits ER stress-induced glucose regulated protein 78 (GRP78) expression, an ER-localized molecular chaperon. This compound inhibits ER stress-induced CCAAT/enhancer-binding protein homologous protein (CHOP) expression, an apoptotic transcription factor. It alone induces eIF2alpha phosphorylation, which is further increased by ER stress. This chemical inhibits ER stress-induced X-box-binding protein 1 (XBP-1) splicing in the primary cultured glial cells. It (0.0625 to 1.0 g/L) has poignant cytotoxicity to human corneal endothelial (HCE) cells, and the extent of its cytotoxicity is dose- and time-dependent. This compound induces plasma membrane permeability elevation, DNA fragmentation, and apoptotic body formation, proving its apoptosis inducing effect on HCE cells. It above 0.0625 g/L has poignant cytotoxicity on HCE cells in vitro by inducing cell apoptosis, and should be carefully employed in eye clinic.

In vivo

Pranoprofen is orally administered, urinary and fecal excretions of the radioactivity within 3 days are 81.1% and 18.7% of the dose in mice, 51.5% and 39.4% in rats, 81.8% and 9.0% in guinea pigs, and 93.2% and 3.6% in rabbits, respectively. This compound is excreted in the urine exclusively in the form of pranoprofen glucuronide in rabbit. It, especially the R(-)-isomer, is significantly distributed in the kidney of rabbit. This chemical has a preference for glucosidation rather than glucuronidation in mice at low doses in spite of having a higher capacity of glucuronidation.

References
  • [4] https://pubmed.ncbi.nlm.nih.gov/8364476/
  • [5] https://pubmed.ncbi.nlm.nih.gov/2098544/

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