Catalog No.S1645 Synonyms: RP-19583

For research use only.

Ketoprofen (RP-19583) is a dual COX1/2 inhibitor, used as a nonsteroidal anti-inflammatory drug to treat arthritis-related inflammatory pains.

Ketoprofen  Chemical Structure

CAS No. 22071-15-4

Selleck's Ketoprofen has been cited by 2 Publications

Purity & Quality Control

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Biological Activity

Description Ketoprofen (RP-19583) is a dual COX1/2 inhibitor, used as a nonsteroidal anti-inflammatory drug to treat arthritis-related inflammatory pains.
COX-1 [1] COX-2 [1]
In vitro

Ketoprofen combined with UVB irradiation induces the cytotoxicity and suppresses DNA synthesis in HaCaT cells in a concentration-dependent manner. Ketoprofen combined with UVB irradiation inhibits the cell growth and induces G2/M cell cycle arrest by modulating the levels of cdc2, cyclin B1, Chk1, Tyr15-phosphorylated cdc2 and p21. Ketoprofen combined with UVB irradiation also provokes a striking accumulation of cyclin B1-cdc2-p21 complexes, concomitantly with an increase in the levels of Tyr15-phosphorylated cdc2 and p21 protein. Ketoprofen combined with UVB irradiation accentuates the apoptotic response to UVB radiation in HaCaT cells as evidenced by DAPI staining. [1]

In vivo Ketoprofen at 1% level in suitable topical vehicles can effectively inhibit GCF-LTB4 and GCF-PGE2 and positively alter alveolar bone activity in the ligature-induced model of periodontitis in the monkey. [2] Ketoprofen (3.63 mg/kg bwt) reduces hoof pain andlameness to a greater extent than the 2.2 mg/kg dose and phenylbutazone. [3] Ketoprofen is more effective than local anesthesia (LA), or caudal epidural anesthesia (EPI) in decreasing cortisol and partially reverses the reduction in average daily gain (ADG) following castration. [4] Ketoprofen (40 and 80 mg/kg diet) reduces the incidence of transitional cell carcinoma of the urinary bladder by >70% from that seen in dietary mice. [5]

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 51 mg/mL
(200.56 mM)
Ethanol 51 mg/mL
(200.56 mM)
Water Insoluble

Chemical Information

Molecular Weight 254.28


CAS No. 22071-15-4
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC(C1=CC(=CC=C1)C(=O)C2=CC=CC=C2)C(=O)O

In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04678076 Completed Drug: Ketoprofen Lysine|Drug: Ketoprofen Oral Product Healthy Aziende Chimiche Riunite Angelini Francesco S.p.A|Cross Research S.A. July 23 2018 Phase 1
NCT02796547 Withdrawn Drug: Levobupivacaine|Other: Physiological serum Episiotomy Brugmann University Hospital July 14 2016 Phase 2
NCT01541059 Completed Drug: Placebo injection|Drug: Ropivacaine injection Third Molar Extraction Centre Hospitalier Universitaire de Nīmes June 2012 Phase 4
NCT01854411 Completed Other: analgesic measure Analgesics Use During Breastfeeding and Concentrations in Human Mature Milk Assistance Publique - Hôpitaux de Paris September 2011 --

(data from, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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