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Trometamol COX inhibitor

Cat.No.S4176

Trometamol(Tromethamine) is a proton acceptor used to treat acidemia.
Trometamol COX inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 121.14

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Quality Control

Batch: S417601 Water]24 mg/mL]false]DMSO]2 mg/mL]false]Ethanol]Insoluble]false Purity: 100.0%
100.0

Chemical Information, Storage & Stability

Molecular Weight 121.14 Formula

C4H11NO3

 Storage (From the date of receipt)
CAS No. 77-86-1 Download SDF Storage of Stock Solutions

Synonyms Tromethamine Smiles C(C(CO)(CO)N)O

Solubility

In vitro
Batch:

Water : 24 mg/mL

DMSO : 2 mg/mL (16.5 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Mechanism of Action

Targets/IC50/Ki
proton acceptor [1]
In vitro

Trometamol is a proton acceptor that generates NH3 +/HCO3 - without generating CO2, and the protonated R-NH3 + is eliminated by the kidneys. This compound is the buffer of choice in the situation where CO2 elimination is impaired (in which case NaHCO3 cannot correct acidemia), and to avoid a Na+ load. Even during short intervals of apneic oxygenation when CO2 elimination is curtailed, this chemical, but not bicarbonate, will maintain a normal arterial pH. It also acts as an osmotic diuretic, increasing urine flow, urinary pH, and excretion of fixed acids, carbon dioxide and electrolytes. A significant fraction of this compound is not ionized and therefore is capable of reaching equilibrium in total body water. This portion may penetrate cells and may neutralize acidic ions of the intracellular fluid. [1]
In vivo

The drug is rapidly eliminated by the kidney; 75% or more appears in the urine after eight hours. Urinary excretion continues over a period of three days. The maximum daily dose is 15 mmol/kg for an adult. In large doses, this compound may induce respiratory depression and hypoglycemia. [1]
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02086097 Completed
Irreversible Pulpitis
Daniel Chavarría Bolaños|Universidad Autonoma de San Luis Potosí
 August 2013 Phase 4
NCT01365611 Completed
Healthy Subjects
Egalet Ltd
 February 2007 Phase 1

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