COX-1 Selective Inhibitors

Catalog No. Product Name Information Selective / Pan IC50 / Ki
S1723 Indomethacin

Indomethacin is a nonselective COX1 and COX2 inhibitor with IC50 of 0.1 μg/mL and 5 μg/mL, respectively, used to reduce fever, pain, stiffness, and swelling.

Selective COX1, IC50: 0.28 μM
S1638 Ibuprofen

Ibuprofen (Dolgesic) is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50 of 13 μM and 370 μM, respectively.

Selective COX-1, IC50: 13 μM
S3200 Triflusal

Triflusal irreversibly inhibits the production of thromboxane-B2 in platelets by acetylating cycloxygenase-1.

S2047 Lornoxicam

Lornoxicam is a COX-1 and COX-2 inhibitor with IC50 of 5 nM and 8 nM, respectively.

Pan COX-1, IC50: 5 nM
S4295 Meclofenamate Sodium

Meclofenamate Sodium is a dual COX-1/COX-2 inhibitor with IC50 of 40 nM and 50 nM, respectively, used in the treatment of joint, muscular pain, arthritis and dysmenorrhea.

Pan COX-1, IC50: 40 nM
S1903 Diclofenac Sodium

Diclofenac Sodium is a non-selective COX inhibitor with IC50 of 60 and 220 nM for ovine COX-1 and -2, respectively.

Pan COX-1, IC50: 60 nM
S4149 Amfenac Sodium Monohydrate

Amfenac Sodium monohydrate is a non-steroidal analgesic anti-inflammatory drug with acetic acid moiety.

Pan COX-1, IC50: 250 nM
S1645 Ketoprofen

Ketoprofen is a non-selective NSAID with IC50 of 0.5 μM and 2.33 μM for human recombinant COX-1 and COX-2, respectively.

Pan COX-1, IC50: 0.5 μM
S1646 Ketorolac

Ketorolac (Ketorolac tromethamine) is a non-selective COX inhibitor of COX-1 and COX-2 with IC50 of 1.23 μM and 3.50 μM, respectively.

Pan COX-1 (human), IC50: 1.23 μM
S2903 Lumiracoxib

Lumiracoxib is a novel, selective COX-2 inhibitor with IC50 and Ki of 0.14 μM and 0.06 μM, exhibits 515-fold selectivity over COX-1. Phase 4.

Pan COX-1, Ki: 3.2 μM
S1626 Naproxen Sodium

Naproxen Sodium is a COX inhibitor for COX-1 and COX-2 with IC50 of 8.7 μM and 5.2 μM, respectively.

Pan COX-1, IC50: 8.7 μM
S4230 Oxaprozin

Oxaprozin is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID) used to relieve the inflammation, swelling, stiffness, and joint pain associated with osteoarthritis and rheumatoid arthritis.

S3008 Zaltoprofen

Zaltoprofen is an inhibitor of Cox-1 and Cox-2 for treatment of arthritis.

S1255 Nepafenac

Nepafenac is a prodrug of amfenac that acts as an inhibitor of COX-1 and COX-2 activity, used in the treatment of pain and inflammation associated with cataract surgery.

S4078 Mefenamic Acid

Mefenamic Acid is a competitive inhibitor of COX-1 and COX-2.

S3017 Aspirin

Aspirin is a salicylate, and irreversible COX1 and COX2 inhibitor, used as an analgesic to relieve minor aches and pains, as an antipyretic to reduce fever, and as an anti-inflammatory medication.

S4248 Bromfenac Sodium

Bromfenac Sodium is a nonsteroidal anti-inflammatory drug (NSAID), which has anti-inflammatory activity and may block prostaglandin synthesis by inhibiting cyclooxygenase 1 and 2.