Etoricoxib

Catalog No.S4651 Synonyms: Arcoxia, MK-663, MK-0663, Tauxib, Algix, Nucoxia

Etoricoxib Chemical Structure

Molecular Weight(MW): 358.84

Etoricoxib is a new COX-2 selective inhibitor with anti-inflammatory, antipyretic, analgesic, and potential antineoplastic properties.

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Biological Activity

Description Etoricoxib is a new COX-2 selective inhibitor with anti-inflammatory, antipyretic, analgesic, and potential antineoplastic properties.
Targets
COX-2 [1]
In vivo The preferential cyclooxygenase-2 inhibitor etoricoxib significantly reduces the anticonvulsant action of phenytoin and significantly increases the beneficial action of diazepam against maximal electroshock and pentylenetetrazole-induced convulsions in a mouse model[1]. Etoricoxib has the potential to act as an anti-apoptotic and anti- proliferative agent in the colon[2].

Protocol

Cell Research:

[3]

+ Expand
  • Cell lines: Human colon carcinoma cell line HCT-116
  • Concentrations: 200 μM
  • Incubation Time: 2 h
  • Method:

    Human colon carcinoma cell line HCT-116 are treated with various coxibs for 2 h. Subsequently, the cells are harvested and the sphingolipids isolated and determined by LC-MS/MS.


    (Only for Reference)
Animal Research:

[1]

+ Expand
  • Animal Models: Adult albino male mice
  • Formulation: suspended in 0.25% w/v carboxymethyl cellulose
  • Dosages: 10 mg/kg
  • Administration: p.o.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 71 mg/mL (197.85 mM)
Ethanol 46 mg/mL (128.19 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 358.84
Formula

C18H15ClN2O2S

CAS No. 202409-33-4
Storage powder
in solvent
Synonyms Arcoxia, MK-663, MK-0663, Tauxib, Algix, Nucoxia

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

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  • Computed Result

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Molecular Weight Calculator

Molecular Weight Calculator

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Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03542955 Recruiting Cervical Osteoarthritis BioElectronics Corporation May 1 2018 Not Applicable
NCT03117894 Recruiting Breast Neoplasm Female|Regional Anesthesia|Anesthesia|Regional Anesthesia Morbidity|Anesthesia Morbidity Umeå University May 23 2017 Not Applicable
NCT03011905 Active not recruiting Brachial Plexus Block|Pain Postoperative Oslo University Hospital January 2017 Phase 3
NCT03582332 Completed Axial Spondyloarthritis Bangabandhu Sheikh Mujib Medical University Dhaka Bangladesh January 2 2016 Phase 4
NCT03422575 Completed Healthy Dexa Medica Group|PT. Equilab International December 2015 Not Applicable
NCT02503839 Recruiting Tuberculosis Anne Margarita Dyrhol Riise|University of Oslo|Statens Serum Institut|Haukeland University Hospital|Oslo University Hospital November 2015 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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COX Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID