Deracoxib

For research use only.

Catalog No.S5711 Synonyms: SC-046

Deracoxib Chemical Structure

CAS No. 169590-41-4

Deracoxib (SC-046) is a COX-2 inhibitor with >48-fold selectivity over COX-1. It also exhibits inhibitory activity against phosphodiesterase (Ki = 3.6 μM against human PDE4D3).

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Biological Activity

Description Deracoxib (SC-046) is a COX-2 inhibitor with >48-fold selectivity over COX-1. It also exhibits inhibitory activity against phosphodiesterase (Ki = 3.6 μM against human PDE4D3).
Targets
COX2 [1]
()
PDE4 [2]
(Cell-free assay)
3.6 μM

Protocol

Cell Research:

[2]

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  • Cell lines: MC4R-GLO cells
  • Concentrations: 10 µM
  • Incubation Time: 5 min
  • Method:

    MC4R-GLO cells were plated in 12 well culture dishes in DMEM/F12 supplemented with 5% fetal bovine serum. Cells were incubated in serum-free medium over night before the experiment. Cells were then treated with the indicated concentration of α-MSH or vehicle for 5 min at 37°C in the presence or absence of 10 µM deracoxib or imperatorin. Dishes were then placed on ice and cells were scraped in 1x LDS-PAGE sample buffer with 100 mM DTT. Proteins were resolved by SDS-PAGE.


    (Only for Reference)

Solubility (25°C)

In vitro DMSO 80 mg/mL (201.32 mM)
Ethanol 20 mg/mL (50.33 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 397.37
Formula

C17H14F3N3O3S

CAS No. 169590-41-4
Storage powder
in solvent
Synonyms SC-046
Smiles COC1=C(C=C(C=C1)C2=CC(=NN2C3=CC=C(C=C3)S(=O)(=O)N)C(F)F)F

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID