Catalog No.S2047 Synonyms: Chlortenoxicam

Lornoxicam Chemical Structure

Molecular Weight(MW): 371.82

Lornoxicam is a non-steroidal COX-1/COX-2 inhibitor, used as an anti-inflammatory drug to treat pain, osteoarthritis, and rheumatoid arthritis.

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Description Lornoxicam is a non-steroidal COX-1/COX-2 inhibitor, used as an anti-inflammatory drug to treat pain, osteoarthritis, and rheumatoid arthritis.
COX-1 [4]
COX-2 [4]
(J774.2 cells)
5 nM 8 nM
In vitro

Lornoxicam is as effective as the opioid analgesics morphine, pethidine (meperidine) and tramadol in relieving postoperative pain following gynaecological or orthopaedic surgery, and as effective as other NSAIDs after oral surgery. Lornoxicam is also as effective as other NSAIDs in relieving symptoms of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute sciatica and low back pain. [1]

In vivo Lornoxicam dose relatedly reduces the total number of c-Fos-LI neurons with the strongest effect corresponding to the 75% reduction for the highest dose of 9 mg/kg, and the 45% reduction for the low dose of 0.3 mg/kg. Lornoxicam (0.1, 0.3 mg/kg, 1 mg/kg, 3 mg/kg and 9 mg/kg, i.v.) significantly reduces the number of c-Fos-LI neurons in both superficial (24%, 33%, 53%, 54%, and 63% reduction, respectively) and deep (28%, 48%, 62%, 69% and 79% reduction, respectively) laminae of the dorsal horn of the spinal cord. [2] Lornoxicam reduces hyperalgesia with an effective dose that provides 50% inhibition (ED50) of 0.083 mg/kg, 3.9 mg/kg and 4.3 mg/kg respectively in a chronic rat model of arthritis. Lornoxicam significantly reduces the PGE2 level in paw exudate and the cerebrospinal fluid in rats. Lornoxicam 0.16 mg/kg, celecoxib 4 mg/kg and loxoprofen 2.4 mg/kg significantly reduces hyperalgesia to a similar extent in acute oedematous rats. [3]


Solubility (25°C)

In vitro DMSO 3 mg/mL warmed (8.06 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 371.82


CAS No. 70374-39-9
Storage powder
in solvent
Synonyms Chlortenoxicam

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02750917 Completed Postoperative Pain Foisor Orthopedics Clinical Hospital September 2014 Phase 3
NCT02025166 Unknown status Pain Rambam Health Care Campus January 2014 Not Applicable
NCT01480752 Completed Post Operative Endodontic Pain Islamic Azad University Tehran September 2011 Phase 2
NCT01069055 Unknown status Inguinal Hernia|Postoperative Pain Diskapi Teaching and Research Hospital February 2010 Phase 3
NCT01117948 Terminated Alzheimer´s Disease JSW Lifesciences September 2009 Phase 2
NCT01564680 Completed Postoperative Pain Dammam University March 2009 Phase 4

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COX Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID