Lornoxicam
Catalog No.S2047 Synonyms: Chlortenoxicam
Molecular Weight(MW): 371.82
Lornoxicam is a non-steroidal COX-1/COX-2 inhibitor, used as an anti-inflammatory drug to treat pain, osteoarthritis, and rheumatoid arthritis.
Purity & Quality Control
Choose Selective COX Inhibitors
Biological Activity
| Description | Lornoxicam is a non-steroidal COX-1/COX-2 inhibitor, used as an anti-inflammatory drug to treat pain, osteoarthritis, and rheumatoid arthritis. | ||||
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| Targets |
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| In vitro |
Lornoxicam is as effective as the opioid analgesics morphine, pethidine (meperidine) and tramadol in relieving postoperative pain following gynaecological or orthopaedic surgery, and as effective as other NSAIDs after oral surgery. Lornoxicam is also as effective as other NSAIDs in relieving symptoms of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute sciatica and low back pain. [1] |
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| In vivo | Lornoxicam dose relatedly reduces the total number of c-Fos-LI neurons with the strongest effect corresponding to the 75% reduction for the highest dose of 9 mg/kg, and the 45% reduction for the low dose of 0.3 mg/kg. Lornoxicam (0.1, 0.3 mg/kg, 1 mg/kg, 3 mg/kg and 9 mg/kg, i.v.) significantly reduces the number of c-Fos-LI neurons in both superficial (24%, 33%, 53%, 54%, and 63% reduction, respectively) and deep (28%, 48%, 62%, 69% and 79% reduction, respectively) laminae of the dorsal horn of the spinal cord. [2] Lornoxicam reduces hyperalgesia with an effective dose that provides 50% inhibition (ED50) of 0.083 mg/kg, 3.9 mg/kg and 4.3 mg/kg respectively in a chronic rat model of arthritis. Lornoxicam significantly reduces the PGE2 level in paw exudate and the cerebrospinal fluid in rats. Lornoxicam 0.16 mg/kg, celecoxib 4 mg/kg and loxoprofen 2.4 mg/kg significantly reduces hyperalgesia to a similar extent in acute oedematous rats. [3] |
Protocol
Solubility (25°C)
| In vitro | DMSO | 3 mg/mL warmed (8.06 mM) |
|---|---|---|
| Water | Insoluble | |
| Ethanol | Insoluble |
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Information
| Molecular Weight | 371.82 |
|---|---|
| Formula | C13H10ClN3O4S2 |
| CAS No. | 70374-39-9 |
| Storage | powder |
| in solvent | |
| Synonyms | Chlortenoxicam |
Bio Calculators
Molarity Calculator
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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
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Dilution Calculator
Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:
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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
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Molarity Calculator
Clinical Trial Information
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT03780556 | Completed | Renal Colic | Ain Shams University | January 2 2016 | Not Applicable |
| NCT03780556 | Completed | Renal Colic | Ain Shams University | January 2 2016 | Not Applicable |
| NCT02750917 | Completed | Postoperative Pain | Foisor Orthopedics Clinical Hospital | September 2014 | Phase 3 |
| NCT02750917 | Completed | Postoperative Pain | Foisor Orthopedics Clinical Hospital | September 2014 | Phase 3 |
| NCT02025166 | Unknown status | Pain | Rambam Health Care Campus | January 2014 | Not Applicable |
| NCT02025166 | Unknown status | Pain | Rambam Health Care Campus | January 2014 | Not Applicable |
Tech Support
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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