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Lornoxicam

Name: Lornoxicam
Brand: Selleck Chemicals
SKU: S2047
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Catalog No.S2047 Synonyms: Chlortenoxicam

For research use only.

Lornoxicam (Chlortenoxicam) is a non-steroidal COX-1/COX-2 inhibitor, used as an anti-inflammatory drug to treat pain, osteoarthritis, and rheumatoid arthritis.

CAS No. 70374-39-9

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COX Signaling Pathway Map

Biological Activity

Description

Lornoxicam (Chlortenoxicam) is a non-steroidal COX-1/COX-2 inhibitor, used as an anti-inflammatory drug to treat pain, osteoarthritis, and rheumatoid arthritis.

Targets

COX-1 ^[4] (platelet)	COX-2 ^[4] (J774.2 cells)
5 nM	8 nM

In vitro

Lornoxicam is as effective as the opioid analgesics morphine, pethidine (meperidine) and tramadol in relieving postoperative pain following gynaecological or orthopaedic surgery, and as effective as other NSAIDs after oral surgery. Lornoxicam is also as effective as other NSAIDs in relieving symptoms of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute sciatica and low back pain. ^[1]

In vivo

Lornoxicam dose relatedly reduces the total number of c-Fos-LI neurons with the strongest effect corresponding to the 75% reduction for the highest dose of 9 mg/kg, and the 45% reduction for the low dose of 0.3 mg/kg. Lornoxicam (0.1, 0.3 mg/kg, 1 mg/kg, 3 mg/kg and 9 mg/kg, i.v.) significantly reduces the number of c-Fos-LI neurons in both superficial (24%, 33%, 53%, 54%, and 63% reduction, respectively) and deep (28%, 48%, 62%, 69% and 79% reduction, respectively) laminae of the dorsal horn of the spinal cord. ^[2] Lornoxicam reduces hyperalgesia with an effective dose that provides 50% inhibition (ED50) of 0.083 mg/kg, 3.9 mg/kg and 4.3 mg/kg respectively in a chronic rat model of arthritis. Lornoxicam significantly reduces the PGE2 level in paw exudate and the cerebrospinal fluid in rats. Lornoxicam 0.16 mg/kg, celecoxib 4 mg/kg and loxoprofen 2.4 mg/kg significantly reduces hyperalgesia to a similar extent in acute oedematous rats. ^[3]

Protocol (from reference)

References

[4] Berg J, et al. Inflamm Res. 1999, 48(7):369-79.

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Solubility (25°C)

In vitro	DMSO	3 mg/mL warmed (8.06 mM)
	Water	Insoluble
	Ethanol	Insoluble

Chemical Information

Molecular Weight	371.82
Formula	C₁₃H₁₀ClN₃O₄S₂
CAS No.	70374-39-9
Storage	3 years	-20°C	powder
Storage	2 years	-80°C	in solvent
Smiles	CN1C(=C(C2=C(S1(=O)=O)C=C(S2)Cl)O)C(=O)NC3=CC=CC=N3

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