Home DNA Damage/DNA Repair PARP inhibitor - Wnt/beta-catenin inhibitor WIKI4 For research use only.

WIKI4

WIKI4 is a novel Tankyrase inhibitor with IC50 of 15 nM for TNKS2, and leads to inhibition of Wnt/beta-catenin signaling.

WIKI4 Chemical Structure

WIKI4 Chemical Structure

CAS: 838818-26-1

Selleck's WIKI4 has been cited by 3 publications

Purity & Quality Control

Batch: S749001 DMSO] 7 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 99.97%
99.97

WIKI4 Related Products

Signaling Pathway

PARP Signaling Pathways

PARP Signaling Pathway

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Biological Activity

Description WIKI4 is a novel Tankyrase inhibitor with IC50 of 15 nM for TNKS2, and leads to inhibition of Wnt/beta-catenin signaling.
Targets
TNKS2 [1]
15 nM
In vitro
In vitro WIKI4 inhibitsWnt/ß-catenin signaling in all tested cell lines, including A375, DLD1 colorectal cancer, NALM6 B, U2OS osteosarcoma and hESCs. WIKI4 increases the steady-state abundance of theWnt/ß-catenin inhibitory protein, AXIN1 by inhibiting tankyrase activity, and thus preventing the ubiquitylation and degradation of AXIN proteins.[1]

Chemical Information & Solubility

Molecular Weight 521.59 Formula

C29H23N5O3S
CAS No. 838818-26-1 SDF Download WIKI4 SDF
Smiles COC1=CC=C(C=C1)N2C(=NN=C2SCCCN3C(=O)C4=CC=CC5=C4C(=CC=C5)C3=O)C6=CC=NC=C6
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 7 mg/mL ( (13.42 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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