Home DNA Damage/DNA Repair PARP inhibitor UPF 1069 For research use only.

UPF 1069

UPF 1069 is a selective PARP2 inhibitor with IC50 of 0.3 μM. It is ~27-fold selective against PARP1.

UPF 1069 Chemical Structure

UPF 1069 Chemical Structure

CAS: 1048371-03-4

Selleck's UPF 1069 has been cited by 8 publications

Purity & Quality Control

Batch: Purity: 99.87%
99.87

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Signaling Pathway

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PARP Signaling Pathway

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Biological Activity

Description UPF 1069 is a selective PARP2 inhibitor with IC50 of 0.3 μM. It is ~27-fold selective against PARP1.
Features The most selective PARP2 inhibitor available to date.
Targets
PARP2 [1] PARP1 [1]
0.3 μM 8.0 μM
In vitro
In vitro UPF 1069 is a selective PARP2 inhibitor with IC50 of 0.3 μM while inhibiting PARP1 with IC50 of 8 μM. [1]
In Vivo
In vivo In organotypic hippocampal slices, PARP-2 inhibition with UPF-1069 (0.01-1 mM) causes a concentration-dependent exacerbation (up to 155%) of oxygen-glucose deprivation (OGD)-induced CA1 pyramidal cell death. Higher concentrations, acting on both PARP-1 and PARP-2, have no effect on OGD injury. In mouse mixed cortical cells exposed to OGD, UPF-1069 (1-10 mM) significantly reduces post-ischaemic damage. [1]

Chemical Information & Solubility

Molecular Weight 279.29 Formula

C17H13NO3
CAS No. 1048371-03-4 SDF Download UPF 1069 SDF
Smiles C1=CC=C(C=C1)C(=O)COC2=CC=CC3=C2C=CNC3=O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 56 mg/mL ( (200.5 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
Batch:

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In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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