Picolinamide

For research use only.

Catalog No.S4710 Synonyms: 2-Pyridinecarboxamide, Picolinoylamide, 2-Carbamoylpyridine

Picolinamide Chemical Structure

CAS No. 1452-77-3

Picolinamide (2-Pyridinecarboxamide, Picolinoylamide, 2-Carbamoylpyridine) is found to be a strong inhibitor of poly (ADP-ribose) synthetase of nuclei from rat pancreatic islet cells.

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Description Picolinamide (2-Pyridinecarboxamide, Picolinoylamide, 2-Carbamoylpyridine) is found to be a strong inhibitor of poly (ADP-ribose) synthetase of nuclei from rat pancreatic islet cells.
Targets
PARP [2]
95 μM
In vivo Overnight treatment of rats with picolinamide, administered as a single injection (4 mmol/kg), inhibits Na+/phosphate cotransport by isolated renal brush border membrane vesicles. There is only a small increase (1.5-fold) in renal cortical NAD content after picolinamide treatment[3].

Protocol

Animal Research:[1]
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  • Animal Models: Wistar rats
  • Dosages: 250 mg/kg
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 24 mg/mL (196.52 mM)
Water 24 mg/mL (196.52 mM)
Ethanol '24 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 122.12
Formula

C6H6N2O

CAS No. 1452-77-3
Storage powder
in solvent
Synonyms 2-Pyridinecarboxamide, Picolinoylamide, 2-Carbamoylpyridine
Smiles C1=CC=NC(=C1)C(=O)N

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID