Home DNA Damage/DNA Repair Topoisomerase inhibitor Ellagic acid

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Ellagic acid Topoisomerase inhibitor

Cat.No.S1327

Ellagic acid (Elagostasine, Gallogen) has antiproliferative and antioxidant property.
Ellagic acid Topoisomerase inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 302.19

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability Specificity

Quality Control

Batch: S132701 0.5MNAOH]3.82 mg/mL]false]DMSO]0.6 mg/mL]false]Water]Insoluble]false Purity: 99.64%
99.64

Chemical Information, Storage & Stability

Molecular Weight 302.19 Formula

C14H6O8

 Storage (From the date of receipt)
CAS No. 476-66-4 Download SDF Storage of Stock Solutions

Synonyms Elagostasine, Gallogen Smiles C1=C2C3=C(C(=C1O)O)OC(=O)C4=CC(=C(C(=C43)OC2=O)O)O

Solubility

In vitro
Batch:

0.5MNAOH : 3.82 mg/mL

DMSO : 0.6 mg/mL ( (1.98 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Targets/IC50/Ki
Topo I [1]
Topo II [1]

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04958018 Completed
Muscular Injury
Appalachian State University
 June 16 2021 Not Applicable
NCT05025189 Completed
Healthy
University of California Los Angeles|The California Table grape Commission
 October 5 2020 Not Applicable
NCT02056496 Completed
Healthy
National Research Council Spain|Universidad Católica San Antonio de Murcia
 January 2014 Phase 1

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