Pefloxacin Mesylate Dihydrate
Catalog No.S4119 Synonyms: 1589 RB
Molecular Weight(MW): 465.49
Pefloxacin Mesylate Dihydrate is the third generation of fluoroquinolone class of antibacterials, which inhibits Topoisomerase II activity and DNA replication.
Purity & Quality Control
Choose Selective Topoisomerase Inhibitors
|Description||Pefloxacin Mesylate Dihydrate is the third generation of fluoroquinolone class of antibacterials, which inhibits Topoisomerase II activity and DNA replication.|
Pefloxacin like that of other quinolones mainly targets bacterial DNA gyrase (topoisomerase II) which is an essential bacterial enzyme with a variety of activities. Pefloxacin is a strongly bactericidal in a complex manner; the bactericidal effect has been described as 'biphasic' with a single rapidly killing effect followed by a paradoxical reduced killing phase in the presence of increased concentration; in bacterial cells incubated with Pefloxacin, non-replicative DNA synthesis (DNA repair), termed SOS response, is induced and SOS response prevents replication, blocking cell division and producing filarnentation. Thus the end result of the SOS response is harmful for the bacteria with morphological and biochemical disturbances. Pefloxacin is highly active against the Enterobacteriaceae (Citrobacter, Enterobacter, Klebsiella, Morganella, Proteus); the minimal inhibitory concentrations (MICs) of Pefloxacin for all genus and species of this family of bacteria ranges usually between 0.03 and 4 or 8 mg/L; against Salmonella, Shigella and Yersinia the MIC50/MIC90 are lower: 0.12/1.0, 0.06/0.06, 0.12/0.25 mg/L, respectively. The MICs of Pefloxacin for Gram- negative aerobic bacilli, such as Pseudomonas aeruginosa, Acinetobacter spp., Alcaligenes, Pseudomonas spp. , ranges from 1 to 4 mg/L. Gram-positive cocci Staphylococci including S. aureus and coagulase-negative staphylococci even resistant to other antibiotics are susceptible or moderately susceptible to Pefloxacin, with MICs in the range 0.125-0.5 mg/L. The MICs of Pefloxacin for Legionella pneumophila are moderately low (MIC50/MIC90:1.0/1.0mg/L); for Eikenella corrodens, Vibrio cholerae, the MICs are very low, whereas Helicobacter pylori, Listeria monocytogenes and Nocardia astero'ides are resistant to Pefloxacin, with MIC50 of 8 mg/L or more. Mycobacteria are moderately or not susceptible to Pefloxacin and most anaerobes are resistant to Pefloxacin. Mycoplasma spp and Chlamydiae are poorly susceptible to Pefloxacin (MIC50/MIC90: 2/8 mg/L) whereas Rickettsia conori and Coxiella burneti are susceptible at therapeutically achievable concentrations. 
|In vitro||Water||67 mg/mL (143.93 mM)|
|DMSO||9 mg/mL (19.33 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:
Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)
*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).
Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
Molecular Weight Calculator
Enter the chemical formula of a compound to calculate its molar mass and elemental composition:
Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2
Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.