- Inhibitory Selectivity
|Catalog No.||Product Name||Solubility(25°C)|
|S3163||Benztropine mesylate||81 mg/mL||50 mg/mL||81 mg/mL|
|S2456||Chlorpromazine HCl||71 mg/mL||71 mg/mL||71 mg/mL|
|S5796||Vanoxerine dihydrochloride||5 mg/mL||17 mg/mL||2 mg/mL|
|S2452||Amfebutamone (Bupropion) HCl||<1 mg/mL||8 mg/mL||<1 mg/mL|
|S3201||Trifluoperazine 2HCl||96 mg/mL||88 mg/mL||96 mg/mL|
|S2461||Domperidone||<1 mg/mL||48 mg/mL||1 mg/mL|
|S4569||Fluphenazine dihydrochloride||100 mg/mL||100 mg/mL||30 mg/mL|
|S1642||Methyldopa||<1 mg/mL||2 mg/mL||<1 mg/mL|
|S3189||Ropinirole HCl||60 mg/mL||10 mg/mL||<1 mg/mL|
|S2493||Olanzapine||<1 mg/mL||62 mg/mL||9 mg/mL|
|S1763||Quetiapine Fumarate||<1 mg/mL||36 mg/mL||<1 mg/mL|
|S1444||Ziprasidone HCl||<1 mg/mL||90 mg/mL||<1 mg/mL|
|S5565||Triflupromazine hydrochloride||-1 mg/mL||78 mg/mL||-1 mg/mL|
|S9509||Tiapride Hydrochloride||-1 mg/mL||35 mg/mL||-1 mg/mL|
|S5399||Chlorprothixene hydrochloride||-1 mg/mL||70 mg/mL||-1 mg/mL|
|S5714||lurasidone||<1 mg/mL||7 mg/mL||<1 mg/mL|
|S5624||Paliperidone Palmitate||<1 mg/mL||1 mg/mL||3 mg/mL|
|S5559||Tetrahydropalmatine||<1 mg/mL||16 mg/mL||<1 mg/mL|
|S5153||Tetrahydroberberine||-1 mg/mL||6 mg/mL||-1 mg/mL|
|S5428||Promazine hydrochloride||-1 mg/mL||64 mg/mL||-1 mg/mL|
|S5481||Molindone hydrochloride||-1 mg/mL||9 mg/mL||-1 mg/mL|
|S5324||Oxidopamine (hydrobromide)||50 mg/mL||50 mg/mL||50 mg/mL|
|S4889||Perospirone hydrochloride||-1 mg/mL||92 mg/mL||-1 mg/mL|
|S5034||Melitracen hydrochloride||65 mg/mL||65 mg/mL||65 mg/mL|
|S1280||Amisulpride||<1 mg/mL||73 mg/mL||73 mg/mL|
|S1724||Paliperidone||<1 mg/mL||4 mg/mL||<1 mg/mL|
|S1920||Haloperidol||<1 mg/mL||75 mg/mL||8 mg/mL|
|S1771||Chlorprothixene||<1 mg/mL||6 mg/mL||28 mg/mL|
|S4251||Phenothiazine||<1 mg/mL||40 mg/mL||<1 mg/mL|
|S4096||Droperidol||<1 mg/mL||76 mg/mL||<1 mg/mL|
|S3044||Lurasidone HCl||<1 mg/mL||1 mg/mL||<1 mg/mL|
|S2104||Levosulpiride||<1 mg/mL||69 mg/mL||<1 mg/mL|
|S4086||Loxapine Succinate||<1 mg/mL||89 mg/mL||2 mg/mL|
|S4731||Perphenazine||<1 mg/mL||74 mg/mL||74 mg/mL|
|S4151||Penfluridol||<1 mg/mL||100 mg/mL||100 mg/mL|
|S2437||Rotundine||<1 mg/mL||8 mg/mL||<1 mg/mL|
|S4631||Prochlorperazine dimaleate salt||<1 mg/mL||74 mg/mL||2 mg/mL|
|S4257||Alizapride HCl||70 mg/mL||42 mg/mL||<1 mg/mL|
|S4655||Sulpiride||<1 mg/mL||68 mg/mL||<1 mg/mL|
|S1789||Tetrabenazine (Xenazine)||<1 mg/mL||58 mg/mL||32 mg/mL|
|S4219||Azaperone||<1 mg/mL||65 mg/mL||34 mg/mL|
|S4289||Metoclopramide HCl||67 mg/mL||67 mg/mL||67 mg/mL|
|S5066||Pramipexole dihydrochloride||-1 mg/mL||56 mg/mL||-1 mg/mL|
|S1726||Levodopa||<1 mg/mL||<1 mg/mL||<1 mg/mL|
|S2451||Amantadine HCl||38 mg/mL||38 mg/mL||38 mg/mL|
|S2011||Pramipexole 2HCl Monohydrate||60 mg/mL||41 mg/mL||<1 mg/mL|
|S2460||Pramipexole||<1 mg/mL||42 mg/mL||42 mg/mL|
|S2529||Dopamine HCl||38 mg/mL||38 mg/mL||<1 mg/mL|
|S4000||Pergolide Mesylate||82 mg/mL||10 mg/mL||<1 mg/mL|
|S3664||Flupenthixol dihydrochloride||100 mg/mL||100 mg/mL||30 mg/mL|
|S4618||Fenoldopam mesylate||<1 mg/mL||80 mg/mL||<1 mg/mL|
|S7993||SKF38393 HCl||<1 mg/mL||58 mg/mL||6 mg/mL|
|S4639||Brexpiprazole||<1 mg/mL||24 mg/mL||<1 mg/mL|
|S3656||Piribedil||<1 mg/mL||59 mg/mL||59 mg/mL|
|S2168||PD128907 HCl||50 mg/mL||12 mg/mL||<1 mg/mL|
|S4274||Rotigotine||<1 mg/mL||63 mg/mL||63 mg/mL|
|S4732||MPTP hydrochloride||41 mg/mL||20 mg/mL||41 mg/mL|
|S8097||C-DIM12||<1 mg/mL||71 mg/mL||71 mg/mL|
|S3188||(+,-)-Octopamine HCl||38 mg/mL||38 mg/mL||11 mg/mL|
- Dopamine Receptor Inhibitors (59)
- New Dopamine Receptor Products
|Catalog No.||Information||Product Use Citations||Product Validations|
Benztropine is a dopamine transporter (DAT) inhibitor with IC50 of 118 nM.
Chlorpromazine HCl is a dopamine and potassium channel inhibitor with IC50 of 6.1 and 16 μM for inward-rectifying K+ currents and time-independent outward currents.
Low-micromolar amounts of chlorpromazine inhibit SARS-CoV-induced cytopathology. Vero E6 cells in 96-well plates were infected with SARS-CoV isolate Frankfurt-1 (MOI, 0.005) in the presence of 0 to 16 μM CPZ (B), given at t of +1 h p.i. Cells were incubated for 3 days, and viability was monitored using an MTS assay. In parallel, potential compound cytotoxicity was monitored in mock-infected Vero E6 cells. Graphs show the results (averages and SD) of a representative experiment that was performed in quadruplicate. All experiments were repeated at least twice. For each compound, the EC50, CC50, and SI values are given.
Vanoxerine is a potent and selective inhibitor of the presynaptic dopamine uptake complex.
Amfebutamone (Bupropion) HCl is a selective norepinephrine-dopamine reuptake inhibitor with IC50 of 6.5 and 3.4 μM for the reuptake of dopamine and norepinephrine, respectively.
Trifluoperazine is a dopamine D2 receptor inhibitor with IC50 of 1.1 nM.
Domperidone is an oral dopamine D2 receptor antagonist, used to treat nausea and vomiting.
Fluphenazine dihydrochloride is a phenothiazine-class D1DR and D2DR inhibitor. It also inhibits Histamine H1 Receptor.
Methyldopa (Aldomet) is a DOPA decarboxylase competitive inhibitor with an ED50 of 21.8 mg/kg.
Ropinirole a selective dopamine D2 receptors agonist with Ki of 29 nM.
Olanzapine is a high affinity for 5-HT2 serotonin and D2 dopamine receptor antagonist.
Olanzapine and aripiprazole differentially regulate cellular glucose uptake of PBMC. Bar graphs depict cellular glucose uptake assessed by 18F-FDG in PBMC after 72 h of stimulation with the indicated concentrations of olanzapine (Olan, A) or aripiprazole (Arip, B) relative to corresponding DMSO controls (Ctrl) and normalized to protein content. Data are depicted as mean ± SD. P-values were computed by one-way ANOVA followed by Dunnett's Multiple Comparison Test. ***P < 0.001, **P < 0.01, *P < 0.05 versus control; results were obtained from n ¼ 4e6 independent cell isolations measured in duplicate.
Quetiapine Fumarate is an atypical antipsychotic used in the treatment of schizophrenia, bipolar I mania, bipolar II depression, bipolar I depression and shows affinity for various neurotransmitter receptors including serotonin, dopamine, histamine, and adrenergic receptors.
Ziprasidone HCl is a novel and potent dopamine and serotonin (5-HT) receptor antagonist, used in the treatment of schizophrenia and bipolar disorder.
a, Quantification of sterol levels in OPCs (oligodendrocyte progenitor cells) treated with the indicated molecules at 2 μM.
Triflupromazine hydrochloride is an antipsychotic medication of the phenothiazine class.
Tiapride is a drug that selectively blocks D2 and D3 dopamine receptors in the brain and is used to treat a variety of neurological and psychiatric disorders.
Chlorprothixene HCl is the hydrochloride salt form of chlorprothixene, a typical antipsychotic drug of the thioxanthene (tricyclic) class. It exerts strong blocking effects by blocking the 5-HT2 D1, D2, D3, histamine H1, muscarinic and alpha1 adrenergic receptors.
Lurasidone is a second-generation antipsychotic agent that exhibits full antagonism at dopamine D2 and serotonin 5-HT2A receptors with binding affinities Ki = 1 nM and Ki = 0.5 nM, respectively. It also has high affinity for serotonin 5-HT7 receptors (Ki = 0.5 nM), partial agonist activity at 5-HT1A receptors (Ki = 6.4 nM) and lacks affinity for histamine H1 and muscarinic M1 receptors.
Paliperidone Palmitate is a palmitate ester of paliperidone, which is a dopamine antagonist and 5-HT2A antagonist of the atypical antipsychotic class.
Tetrahydropalmatine, a plant alkaloid used as an ingredient in dietary supplement products, is a potent and selective D1 receptor antagonist.
Tetrahydroberberine is an isoquinoline alkaloid with micromolar affinity for dopamine D2 (antagonist, pKi = 6.08) and 5-HT1A (agonist, pKi = 5.38) receptors but moderate to no affinity for other relevant serotonin receptors.
Promazine is an antagonist at types 1, 2, and 4 dopamine receptors, 5-HT receptor types 2A and 2C, muscarinic receptors 1 through 5, alpha(1)-receptors, and histamine H1-receptors with antipsychotic effects.
Molindone hydrochloride is the hydrochloride salt form of molindone, a conventional antipsychotic used in the therapy of schizophrenia. It is a dopamine D2/D5 receptor antagonist.
Oxidopamine is a neurotoxic synthetic organic compound that acts as an antagonist of the neurotransmitter dopamine with potential antineoplastic activity.
Perospirone is an atypical or second-generation antipsychotic of the azapirone family that antagonizes serotonin 5HT2A receptors and dopamine D2 receptors. It also displays affinity towards 5HT1A receptors as a partial agonist.
Melitracen hydrochloride is a potential dopamine D1/2 receptor antagonist which has antidepressant properties.
Amisulpride is an atypical antipsychotic used to treat psychosis in schizophrenia and episodes of mania in bipolar disorder.
Paliperidone, the main active metabolite of Risperidone, is a potent serotonin-2A and dopamine-2 receptor antagonist, used in the treatment of schizophrenia.
Haloperidol (Haldol) is an antipsychotic and butyrophenone.
Chlorprothixene has strong binding affinities to dopamine and histamine receptors, such as D1, D2, D3, D5, H1, 5-HT2, 5-HT6 and 5-HT7, with Ki of 18 nM, 2.96 nM, 4.56 nM, 9 nM, 3.75 nM, 9.4 nM, 3 nM and 5.6 nM, respectively.
Phenothiazine is a dopamine-2 (D2) receptor antagonist therefore decreases the effect of dopamine in the brain.
Droperidol is a potent antagonist of dopamine subtype 2 receptors in the limbic system.
Lurasidone is an atypical antipsychotic, inhibits Dopamine D2, 5-HT2A, 5-HT7, 5-HT1A and noradrenaline α2C with IC50 of 1.68 nM, 2.03 nM, 0.495 nM, 6.75 nM and 10.8 nM, respectively.
Levosulpiride is a selective antagonist for D2 dopamine receptors used as an antipsychotic and prokinetic agent.
Loxapine Succinate is a D2DR and D4DR inhibitor, serotonergic receptor antagonist and also a dibenzoxazepine anti-psychotic agent.
Perphenazine is a phenothiazine derivative and a dopamine antagonist with antiemetic and antipsychotic properties.
Penfluridol is a highly potent, first generation diphenylbutylpiperidine antipsychotic.
Rotundine (L-tetrahydropalmatine, L-THP) is a selective dopamine D1 receptor antagonist with IC50 of 166 nM.
Prochlorperazine dimaleate is a dopamine (D2) receptor antagonist.
Alizapride HCl is a dopamine receptor antagonist used for the theropy of nausea and vomiting.
Sulpiride is a dopamine D2-receptor antagonist. It has been used therapeutically as an antidepressant, antipsychotic, and as a digestive aid.
Tetrabenazine(Nitoman, Xenazine) acts primarily as a reversible high-affinity inhibitor of mono-amine uptake into granular vesicles of presynaptic neurons by binding selectively to VMAT-2; Also blocks dopamine D2 receptors, but this affinity is 1,000-fold lower than its affinity for VMAT-2.
Azaperone crosses the blood-brain barrier and binds to both DI and D2 receptors, being an antagonist of Dopamine receptors with sedative and antiemetic effects, which is used mainly as a tranquilizer in veterinary medicine.
Metoclopramide HCl is a selective dopamine D2 receptor antagonist, used for the treatment of nausea and vomiting.
Pramipexole dihydrochloride is a dopamine agonist of the non-ergoline class indicated for treating Parkinson's disease (PD) and restless legs syndrome (RLS) with Ki values of 3.9 nM, 2.2 nM, 0.5 nM and 5.1 nM for D2S receptor, D2L receptor, D3 receptor and D4 receptor.
Levodopa is the precursor to the neurotransmitters dopamine, norepinephrine (noradrenaline), and epinephrine (adrenaline), used to treat Parkinson's symptoms.
(A) A focused screening of Aβ generation in response to levodopa, piribedil, bromocriptine or carbidopa at indicated concentrations in SK-N-SH cells. Data are mean ± s.e.m., n = 3-4. *p < 0.05; ***p < 0.001 versus the control of each group.
Amantadine HCl is used to treat or prevent infections of the respiratory tract caused by a certain virus.
Pramipexole 2HCl Monohydrateis a novel non-ergoline dopamine (DA) agonist, used to treat Parkinson's disease.
Pramipexole is a partial/full D2S, D2L, D3, D4 receptor agonist with a Ki of 3.9, 2.2, 0.5 and 5.1 nM for D2S, D2L, D3, D4 receptor, respectively.
Dopamine HCl is a catecholamine neurotransmitter present in a wide variety of animals,And a dopamine D1-5 receptors agonist.
Pergolide Mesylate is an antiparkinsonian agent which functions as a dopaminergic agonist.
Flupentixol, an antipsychotic neuroleptic drug, is a powerful antagonist of both D1 and D2 dopamine receptors and also an alpha-adrenergic receptor antagonist.
Fenoldopam is a selective dopamine-1 receptor (DA1) agonist with natriuretic/diuretic properties. It lowers blood pressure through arteriolar vasodilation.
SKF38393 HCl is a selective dopamine D1/D5 receptor agonist.
Brexpiprazole is a novel D2 dopamine and serotonin 1A partial agonist, called serotonin-dopamine activity modulator (SDAM), and a potent antagonist of serotonin 2A receptors, noradrenergic alpha 1B and 2C receptors with Ki values of 0.3, 0.12, 0.47, 0.17 and 0.59 nM for D2L, 5-HT1A, 5-HT2A, α1B receptors and α2C receptors respectivey.
Piribedil is a relatively selective dopamine (D2/D3) agonist with moderate antidepressant activity. It also has α2-adrenergic (α2A/α2C) antagonist properties.
PD 128907 HCl is a potent and selective dopamine D3 receptor agonist, with EC50 of 0.64 nM, exhibits 53-fold selectivity over dopamine D2 receptor.
Rotigotine is a dopamine receptor agonist, used in the treatment of Parkinson's disease and restless legs syndrome.
MPTP hydrochloride is a dopaminergic neurotoxin and cause selective destruction of dopaminergic neurons in animal models of parkinsonism.
C-DIM12 is Nurr1 activator that stimulates Nurr1 mediated apoptosis axis in bladder cancer cells and tumors and inhibits NF-κB–dependent gene expression in glial cells.
Octopamine (OA), a biogenic monoamine structurally related to noradrenaline, acts as a neurohormone, a neuromodulator and a neurotransmitter in invertebrates.