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Dopamine Receptor Antagonist/Agonists

Other Neuronal Signaling Related Inhibitors

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Isoform-selective Products

Cat.No. Product Name Information Product Use Citations Product Validations
S6887 Clozapine N-oxide (CNO chemical) CNO (Clozapine N-oxide) is a metabolite of Clozapine (GLXC-06516) and an agonist of human muscarinic designer receptors (Designer Receptors Exclusively Activated by Designer Drugs, DREADDs). Clozapine is a potent dopamine (DA) antagonist and a selective muscarinic M4 receptor agonist.Solutions are unstable and should be fresh-prepared.
Theranostics, 2025, 15(5):1822-1841
STAR Protoc, 2025, 6(1):103542
Theranostics, 2024, 14(7):2881-2896
S5749 Chlorpromazine Chlorpromazine (CPZ) is a low-potency typical antipsychotic agent that is used to treat psychotic disorders such as schizophrenia. This compound inhibits 5-HT(2A) receptor and dopamine D2 in vitro. It also inhibits sodium channel and blocks HERG potassium channels with IC50 of 21.6 μM.
EMBO J, 2025, 10.1038/s44318-025-00537-7
Mol Psychiatry, 2025, 10.1038/s41380-025-03374-6
J Thromb Haemost, 2025, 23(9):2926-2943
S4732 MPTP Hydrochloride MPTP hydrochloride is a dopaminergic neurotoxin and cause selective destruction of dopaminergic neurons in animal models of parkinsonism. MPTP hydrochloride induces apoptosis.MPTP hydrochloride can be used to induce animal models of Parkinson’s disease.
Inflammation, 2025, 10.1007/s10753-025-02306-4
Front Aging Neurosci, 2025, 17:1551404
Exp Cell Res, 2025, 449(2):114602
S2456 Chlorpromazine HCl Chlorpromazine HCl is a dopamine and potassium channel inhibitor with IC50 of 6.1 and 16 μM for inward-rectifying K+ currents and time-independent outward currents.
J Colloid Interface Sci, 2024, 664:338-348
Virus Res, 2024, 339:199258
Cell Mol Immunol, 2022, 19(8):925-943
Verified customer review of Chlorpromazine HCl
S5856 Trifluoperazine Trifluoperazine (NSC-17474, RP-7623, SKF-5019) is an FDA-approved antipsychotic drug for schizophrenia. It is an inhibitor of calmodulin (CaM) and Dopamine D2 receptor with an IC50 value of 1.2 nM for D2 receptor.
Toxicol Appl Pharmacol, 2025, 500:117393
Glia, 2024,
Chem Biol Interact, 2024, 395:111023
S3201 Trifluoperazine 2HCl Trifluoperazine (NSC-17474, RP-7623, SKF-5019) 2HCl is a dopamine D2 receptor inhibitor with IC50 of 1.1 nM. Trifluoperazine also inhibits calmodulin (CaM).
Theranostics, 2025, 15(17):9073-9090
Antiviral Res, 2024, 222:105817
Front Microbiol, 2022, 13:979904
S2529 Dopamine HCl Dopamine HCl(ASL279, NSC 173182) is a catecholamine neurotransmitter present in a wide variety of animals,And a dopamine D1-5 receptors agonist.
iScience, 2023, 26(3):106241
Cell Rep Methods, 2023, 3(10):100599
Front Microbiol, 2022, 13:979904
S4151 Penfluridol Penfluridol (TLP-607,R-16341) is a highly potent, first generation diphenylbutylpiperidine antipsychotic.
Signal Transduct Target Ther, 2025, 10(1):341
Transl Oncol, 2025, 62:102559
Acta Pharm Sin B, 2022, 12(3):1271-1287
S4631 Prochlorperazine dimaleate salt Prochlorperazine dimaleate salt is a dopamine (D2) receptor antagonist.
Cell Rep Med, 2025, 6(11):102421
Cancer Biol Ther, 2023, 24(1):2269637
Cancer Biol Ther, 2023, 10.1080/15384047.2023.2269637
S1763 Quetiapine (ICI-204636) fumarate Quetiapine Fumarate (ICI-204636) is an atypical antipsychotic used in the treatment of schizophrenia, bipolar I mania, bipolar II depression, bipolar I depression and shows affinity for various neurotransmitter receptors including serotonin, dopamine, histamine, and adrenergic receptors.
Front Microbiol, 2022, 13:979904
Clin Transl Sci, 2021, 10.1111/cts.13012
J Cancer Res Clin Oncol, 2019, 145(6):1495-1507

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