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Dopamine Receptor Antagonist/Agonists

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Isoform-selective Products

Cat.No. Product Name Information Product Use Citations Product Validations
S6887 Clozapine N-oxide (CNO chemical) CNO (Clozapine N-oxide) is a metabolite of Clozapine (GLXC-06516) and an agonist of human muscarinic designer receptors (Designer Receptors Exclusively Activated by Designer Drugs, DREADDs). Clozapine is a potent dopamine (DA) antagonist and a selective muscarinic M4 receptor agonist.Solutions are unstable and should be fresh-prepared.
Molecular Medicine, November 23, 2025, nan
Frontiers in Aging Neuroscience, November 11, 2022, 1040569
Theranostics, 2025, 15(5):1822-1841
S5749 Chlorpromazine (CPZ) Chlorpromazine (CPZ) is a low-potency typical antipsychotic agent that is used to treat psychotic disorders such as schizophrenia. Chlorpromazine (CPZ) inhibits 5-HT(2A) receptor and dopamine D2 in vitro. Chlorpromazine (CPZ) also inhibits sodium channel and blocks HERG potassium channels with IC50 of 21.6 μM.
EMBO J, 2025, 10.1038/s44318-025-00537-7
Mol Psychiatry, 2025, 10.1038/s41380-025-03374-6
J Thromb Haemost, 2025, 23(9):2926-2943
S4732 MPTP Hydrochloride MPTP hydrochloride is a dopaminergic neurotoxin and cause selective destruction of dopaminergic neurons in animal models of parkinsonism. MPTP hydrochloride induces apoptosis.MPTP hydrochloride can be used to induce animal models of Parkinson’s disease.
Inflammation, 2025, 10.1007/s10753-025-02306-4
Front Aging Neurosci, 2025, 17:1551404
Exp Cell Res, 2025, 449(2):114602
S2456 Chlorpromazine HCl Chlorpromazine HCl is a dopamine and potassium channel inhibitor with IC50 of 6.1 and 16 μM for inward-rectifying K+ currents and time-independent outward currents.
J Colloid Interface Sci, 2024, 664:338-348
Virus Res, 2024, 339:199258
Cell Mol Immunol, 2022, 19(8):925-943
Verified customer review of Chlorpromazine HCl
S5856 Trifluoperazine Trifluoperazine (NSC-17474, RP-7623, SKF-5019) is an FDA-approved antipsychotic drug for schizophrenia. It is an inhibitor of calmodulin (CaM) and Dopamine D2 receptor with an IC50 value of 1.2 nM for D2 receptor.
Chemical Research in Toxicology, 2026, Online ahead of print
Chemical Research in Toxicology, 2026, nan
Toxicol Appl Pharmacol, 2025, 500:117393
S3201 Trifluoperazine 2HCl Trifluoperazine (NSC-17474, RP-7623, SKF-5019) 2HCl is a dopamine D2 receptor inhibitor with IC50 of 1.1 nM. Trifluoperazine also inhibits calmodulin (CaM).
Frontiers in Microbiology, November 1, 2022, 979904
Antiviral Research, February 2024, 105817
EMBO Molecular Medicine, December 23, 2025, 433-461
S1763 Quetiapine (ICI-204636) fumarate Quetiapine Fumarate (ICI-204636) is an atypical antipsychotic used in the treatment of schizophrenia, bipolar I mania, bipolar II depression, bipolar I depression and shows affinity for various neurotransmitter receptors including serotonin, dopamine, histamine, and adrenergic receptors.
Toxicology Letters, October 1, 2019, 313:77-90
Anticancer Research, February 2021, 41(2):687-697
Frontiers in Microbiology, 2022, 979904
S4358 Pimozide Pimozide (Orap, R6238) is an antagonist of Dopamine Receptors with Ki of 0.83 nM, 3.0 nM and 6600 nM for dopamine D3, D2 and D1 receptors, respectively. This compound also exhibits binding affinity at 5-HT1A and α1-adrenoceptor with Ki of 310 nM and 39 nM, respectively. It is an antipsychotic drug with anti-tumor activity and suppresses STAT3 and STAT5 activity.
Anticancer Research, October 15, 2018, 5685-5692
Acta Haematologica, January 6, 2025, 729-733
Mol Metab, 2025, 91:102069
S1726 Levodopa Levodopa (L-DOPA) is the precursor to the neurotransmitters dopamine, norepinephrine (noradrenaline), and epinephrine (adrenaline), used to treat Parkinson's symptoms.
PLOS ONE, March 2, 2017, e0173240
Molecular Psychiatry, 2025, 1-12
Mol Psychiatry, 2025, 10.1038/s41380-025-03374-6
Verified customer review of Levodopa
S1280 Amisulpride Amisulpride (DAN-2163) is an atypical antipsychotic used to treat psychosis in schizophrenia and episodes of mania in bipolar disorder.
Frontiers in Microbiology, November 01, 2022, 979904
Alzheimers & Dementia, May 23, 2023, 5482-5497
Communications Medicine, 2025, 420

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