PD128907 HCl

Catalog No.S2168

For research use only.

PD 128907 HCl is a potent and selective dopamine D3 receptor agonist, with EC50 of 0.64 nM, exhibits 53-fold selectivity over dopamine D2 receptor.

PD128907 HCl Chemical Structure

CAS No. 112960-16-4

Selleck's PD128907 HCl has been cited by 1 Publication

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Biological Activity

Description PD 128907 HCl is a potent and selective dopamine D3 receptor agonist, with EC50 of 0.64 nM, exhibits 53-fold selectivity over dopamine D2 receptor.
Targets
D3 receptor [1]
0.64 nM(EC50)
In vitro

PD 128907 HCl is a potent and selective dopamine D3 receptor agonist, with EC50 of 0.64 nM, exhibits 53-fold selectivity over dopamine D2 receptor. [1] When using [3H]spiperone as the radioligand in CHOKl-cells, PD 128907 exhibits about a l000-fold selectivity for human D3 receptors (Ki, 1 nM) versus human D2 receptors (Ki, 1183 nM) and a l0000-fold selectivity versus human D4receptors (Ki, 7000 nM) [2] PD 128907 is used for studying the role of these receptors in the brain, in roles such as inhibitory autoreceptors that act to limit further dopamine release.[3]

In vivo PD 128907 is active in reducing DA synthesis both in normal and γ-butyrolactone (GBL) treated rats. [4] PD 128907 (3 mg/kg) reduces toxicity from cocaine overdose, completely prevented the convulsant and lethal effects of cocaine. [5] The protection occurs through a D3-linked mechanism and that protection is extended to seizure kindling. [6]

Protocol (from reference)

Animal Research:[5]
  • Animal Models: Mouse
  • Dosages: 3 mg/kg
  • Administration: i.p.

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 285.77
Formula

C14H19NO3.HCl

CAS No. 112960-16-4
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CCCN1CCOC2C1COC3=C2C=C(C=C3)O.Cl

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