Catalog No.S2460 Synonyms: SND 919

For research use only.

Pramipexole (SND 919) is a partial/full D2S, D2L, D3, D4 receptor agonist with a Ki of 3.9, 2.2, 0.5 and 5.1 nM for D2S, D2L, D3, D4 receptor, respectively.

Pramipexole Chemical Structure

CAS No. 104632-26-0

Purity & Quality Control

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Biological Activity

Description Pramipexole (SND 919) is a partial/full D2S, D2L, D3, D4 receptor agonist with a Ki of 3.9, 2.2, 0.5 and 5.1 nM for D2S, D2L, D3, D4 receptor, respectively.
D3 receptor [1] D2L Receptor [1] D2S Receptor [1] D4 receptor [1]
0.5 nM(Ki) 2.2 nM(Ki) 3.9 nM(Ki) 5.1 nM(Ki)
Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
CHO cells M2LwXWZ2dmO2aX;uJIF{e2G7 M3Tnemhq\2hiaX7obYJqfGmxbjDjc45{fGGwdDDh[4FqdnO2IGuzTH1{eGmyZYLvcoUh[mmwZHnu[{B1dyCqdX3hckBFd3CjbXnu[UBz\WOncITvdkBFOyCneIDy[ZN{\WRiaX6gR2hQKGOnbHzzMEBMcT1yLki4JI5O MkTrNVU5ODF6M{m=

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 42 mg/mL
(198.74 mM)
Ethanol 42 mg/mL
(198.74 mM)
Water Insoluble

In vivo

Add solvents to the product individually and in order
(Data is from Selleck tests instead of citations):
2% DMSO+40% PEG 300+2% Tween 80+ddH2O
For best results, use promptly after mixing.


Chemical Information

Molecular Weight 211.33


CAS No. 104632-26-0
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CCCNC1CCC2=C(C1)SC(=N2)N

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03683225 Unknown status Combination Product: CTC-413 Idiopathic Parkinson Disease Chase Therapeutics Corporation April 1 2019 Phase 2
NCT03642964 Active not recruiting Drug: CTC-501 Major Depressive Disorder (MDD) Chase Therapeutics Corporation September 10 2018 Phase 2
NCT02101138 Unknown status Drug: Dexpramipexole Hypereosinophilic Syndrome National Institute of Allergy and Infectious Diseases (NIAID)|Knopp Biosciences|National Institutes of Health Clinical Center (CC) March 14 2014 Phase 2
NCT01733199 Completed Other: questionnaires Parkinson''s Disease|Secondary Behavioural Addiction Nantes University Hospital October 2012 Phase 4
NCT01607034 Completed Drug: Dexpramipexole Healthy Volunteers Knopp Biosciences June 2012 Phase 1
NCT01597310 Completed Drug: Warfarin|Drug: Dexpramipexole Healthy Volunteers Knopp Biosciences May 2012 Phase 1

(data from, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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