Pramipexole

Catalog No.S2460 Synonyms: SND 919

Pramipexole Chemical Structure

Molecular Weight(MW): 211.33

Pramipexole is a partial/full D2S, D2L, D3, D4 receptor agonist with a Ki of 3.9, 2.2, 0.5 and 5.1 nM for D2S, D2L, D3, D4 receptor, respectively.

Size Price Stock Quantity  
In DMSO USD 90 In stock
USD 70 In stock
USD 170 In stock
USD 370 In stock
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Biological Activity

Description Pramipexole is a partial/full D2S, D2L, D3, D4 receptor agonist with a Ki of 3.9, 2.2, 0.5 and 5.1 nM for D2S, D2L, D3, D4 receptor, respectively.
Targets
D3 receptor [1] D2L Receptor [1] D2S Receptor [1] D4 receptor [1]
0.5 nM(Ki) 2.2 nM(Ki) 3.9 nM(Ki) 5.1 nM(Ki)
Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
CHO cells M13xR2Z2dmO2aX;uJIF{e2G7 MWTIbYdpKGmwaHnibZRqd25iY3;ud5RidnRiYXfhbY5{fCCdM1jdd5BqeGW{b37lJIJqdmSrbnegeI8hcHWvYX6gSI9x[W2rbnWgdoVk\XC2b4KgSFMh\XiycnXzd4VlKGmwIFPIU{Bk\WyuczygT4k:OC56ODDuUS=> M3vL[VE2QDBzOEO5

... Click to View More Cell Line Experimental Data

Protocol

Solubility (25°C)

In vitro DMSO 42 mg/mL (198.74 mM)
Ethanol 42 mg/mL (198.74 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+40% PEG 300+2% Tween 80+ddH2O
For best results, use promptly after mixing.
11mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 211.33
Formula

C10H17N3S

CAS No. 104632-26-0
Storage powder
in solvent
Synonyms SND 919

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

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Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03683225 Recruiting Combination Product: CTC-413 Idiopathic Parkinson Disease Chase Therapeutics Corporation April 1 2019 Phase 2
NCT03642964 Active not recruiting Drug: CTC-501 Major Depressive Disorder (MDD) Chase Therapeutics Corporation September 10 2018 Phase 2
NCT02101138 Active not recruiting Drug: Dexpramipexole Hypereosinophilic Syndrome National Institute of Allergy and Infectious Diseases (NIAID)|Knopp Biosciences|National Institutes of Health Clinical Center (CC) March 14 2014 Phase 2
NCT01733199 Completed Other: questionnaires Parkinson''s Disease|Secondary Behavioural Addiction Nantes University Hospital October 2012 Phase 4
NCT01607034 Completed Drug: Dexpramipexole Healthy Volunteers Knopp Biosciences June 2012 Phase 1
NCT01597310 Completed Drug: Warfarin|Drug: Dexpramipexole Healthy Volunteers Knopp Biosciences May 2012 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Dopamine Receptor Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID