Trifluoperazine 2HCl

For research use only.

Catalog No.S3201 Synonyms: SKF5019

5 publications

Trifluoperazine 2HCl Chemical Structure

CAS No. 440-17-5

Trifluoperazine (SKF5019) is a dopamine D2 receptor inhibitor with IC50 of 1.1 nM.

Selleck's Trifluoperazine 2HCl has been cited by 5 publications

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Biological Activity

Description Trifluoperazine (SKF5019) is a dopamine D2 receptor inhibitor with IC50 of 1.1 nM.
Targets
Dopamine D2 receptor [1]
1.1 nM
In vitro

Trifluoperazine binds to α1A- and α1B-adrenoceptor with Ki value of 27.6 nM and 19.2 nM, respectively, with α1B/α1A ratio of 0.7. [2] Trifluoperazine inhibits Mycobacterium tuberculosis (Mtb) with MICs of 7.6 μg/mL. [3] Trifluoperazine (< 14.78 mM) suppresses the activities of the mouse splenic NK cell cytotoxicity and the effector-target cell conjugation in a dose dependent manner. Trifluoperazine suppresses interferon-alpha or interleukin-2 induced augmentation of the cytolytic activity of NK cells. [4] Trifluoperazine inhibits the gene expression of voltage-dependent potassium channel Kv2.1 from human brain (hKv2.1). [5]

In vivo Trifluoperazine dose dependently decreases avoidance responses and increases response failures in rats where behavior is maintained under a discrete-trial avoidance. [6]

Protocol

Solubility (25°C)

In vitro Water 96 mg/mL (199.82 mM)
Ethanol 96 mg/mL (199.82 mM)
DMSO 88 mg/mL (183.17 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 480.42
Formula

C21H24F3N3S.2HCl

CAS No. 440-17-5
Storage powder
in solvent
Synonyms SKF5019
Smiles CN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)C(F)(F)F.Cl.Cl

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Dopamine Receptor Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID