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Catalog No.S1726

1 publication

Levodopa  Chemical Structure

CAS No. 59-92-7

Levodopa is the precursor to the neurotransmitters dopamine, norepinephrine (noradrenaline), and epinephrine (adrenaline), used to treat Parkinson's symptoms.

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Selleck's Levodopa has been cited by 1 publication

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  • (A) A focused screening of Aβ generation in response to levodopa, piribedil, bromocriptine or carbidopa at indicated concentrations in SK-N-SH cells. Data are mean ± s.e.m., n = 3-4. *p < 0.05; ***p < 0.001 versus the control of each group.

    PLoS ONE, 12(3), e0173240. Levodopa purchased from Selleck.

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Description Levodopa is the precursor to the neurotransmitters dopamine, norepinephrine (noradrenaline), and epinephrine (adrenaline), used to treat Parkinson's symptoms.
Dopamine receptor [1]
In vitro

Levodopa produces at 25-200 μM concentrations a dose-dependent reduction of 3H-DA uptake in foetal rat midbrain cultures. Levodopa results in a decrease in the number of viable cells and tyrosine hydroxylase (TH) positive neurones, plus disruption of the overall neuritic network. [1] Levodopa induces dyskinesia in the absence of dopamine by excessive inhibition of neurons of the putamen-globus pallidus (GPe) projection and subsequent disinhibition of the globus pallidus (GPe). Levodopa results in a decrease in cytochrome oxidase messenger RNA expression in the globus pallidus (GPi). [2]

In vivo Levodopa elicits the development of a variety of abnormal movements in monkeys with parkinsonism induced by the neurotoxin MPTP. Levodopa administrations result in an ectopic induction of the dopamine D3receptor expression in the CdPu in 6-OHDA-lesioned rats. [3] Levodopa (50 mg/kg) increases anandamide concentrations throughout thebasal ganglia via activation of dopamine D1/D2 receptors in intact rats. Levodopa produces increasingly severe oro-lingual involuntary movements which are attenuated by the cannabinoid agonist R(+)-WIN55,212-2 (1 mg/kg) in lesioned rats. [4] Levodopa administration reverses the up-regulation of D2 dopamine receptors seen in severely lesioned rats provided evidence that Levodopa reaches a biologically active concentration at the basal ganglia. [5]


Solubility (25°C)

In vitro DMSO Insoluble
Water Insoluble
Ethanol Insoluble

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Chemical Information

Molecular Weight 197.19


CAS No. 59-92-7
Storage powder
in solvent
Synonyms N/A
Smiles C1=CC(=C(C=C1CC(C(=O)O)N)O)O

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03496870 Completed Drug: Opicapone|Drug: Carbidopa Levodopa Parkinson Disease Neurocrine Biosciences February 8 2018 Phase 1
NCT02486432 Completed Drug: Levodopa/Carbidopa (Sinemet) Parkinson''s Disease NeuroDerm Ltd.|Quotient Clinical April 2015 Phase 1
NCT01026428 Completed Drug: Safinamide + Levodopa|Other: Placebo + Levodopa Idiopathic Parkinson''s Disease Newron Pharmaceuticals SPA September 2009 Phase 1|Phase 2
NCT01327261 Completed Drug: Levodopa + benserazide Healthy Volunteers University of Buenos Aires|Laboratorios Phoenix S.A.I.C.y F. August 2009 Phase 4

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