Catalog No.S1726

For research use only.

Levodopa is the precursor to the neurotransmitters dopamine, norepinephrine (noradrenaline), and epinephrine (adrenaline), used to treat Parkinson's symptoms.

Levodopa  Chemical Structure

CAS No. 59-92-7

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Biological Activity

Description Levodopa is the precursor to the neurotransmitters dopamine, norepinephrine (noradrenaline), and epinephrine (adrenaline), used to treat Parkinson's symptoms.
Dopamine receptor [1]
In vitro

Levodopa produces at 25-200 μM concentrations a dose-dependent reduction of 3H-DA uptake in foetal rat midbrain cultures. Levodopa results in a decrease in the number of viable cells and tyrosine hydroxylase (TH) positive neurones, plus disruption of the overall neuritic network. [1] Levodopa induces dyskinesia in the absence of dopamine by excessive inhibition of neurons of the putamen-globus pallidus (GPe) projection and subsequent disinhibition of the globus pallidus (GPe). Levodopa results in a decrease in cytochrome oxidase messenger RNA expression in the globus pallidus (GPi). [2]

In vivo Levodopa elicits the development of a variety of abnormal movements in monkeys with parkinsonism induced by the neurotoxin MPTP. Levodopa administrations result in an ectopic induction of the dopamine D3receptor expression in the CdPu in 6-OHDA-lesioned rats. [3] Levodopa (50 mg/kg) increases anandamide concentrations throughout thebasal ganglia via activation of dopamine D1/D2 receptors in intact rats. Levodopa produces increasingly severe oro-lingual involuntary movements which are attenuated by the cannabinoid agonist R(+)-WIN55,212-2 (1 mg/kg) in lesioned rats. [4] Levodopa administration reverses the up-regulation of D2 dopamine receptors seen in severely lesioned rats provided evidence that Levodopa reaches a biologically active concentration at the basal ganglia. [5]

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO Insoluble
Water Insoluble
Ethanol Insoluble

Chemical Information

Molecular Weight 197.19


CAS No. 59-92-7
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1=CC(=C(C=C1CC(C(=O)O)N)O)O

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05094011 Not yet recruiting Biological: Aadipose-Derived Mesenchymal Stem Cells Idiopathic Parkinson''s Disease Taiwan Mitochondrion Applied Technology Co. Ltd. February 1 2022 Phase 1
NCT04735627 Recruiting Device: Levodopameter Parkinson Disease University of California San Diego January 2022 Not Applicable
NCT05094050 Recruiting Drug: ABBV-951 Parkinson''s Disease AbbVie December 9 2021 Phase 1
NCT04976127 Recruiting Drug: Talineuren Parkinson Disease InnoMedica Schweiz AG December 7 2021 Phase 1
NCT05083260 Not yet recruiting Drug: NE3107|Drug: placebo Parkinson Disease BioVie Inc. November 2021 Phase 1|Phase 2

(data from https://clinicaltrials.gov, updated on 2022-01-17)

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