Levodopa

For research use only.

Catalog No.S1726

1 publication

Levodopa  Chemical Structure

Molecular Weight(MW): 197.19

Levodopa is the precursor to the neurotransmitters dopamine, norepinephrine (noradrenaline), and epinephrine (adrenaline), used to treat Parkinson's symptoms.

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Selleck's Levodopa has been cited by 1 publication

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  • (A) A focused screening of Aβ generation in response to levodopa, piribedil, bromocriptine or carbidopa at indicated concentrations in SK-N-SH cells. Data are mean ± s.e.m., n = 3-4. *p < 0.05; ***p < 0.001 versus the control of each group.

    PLoS ONE, 12(3), e0173240. Levodopa purchased from Selleck.

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Biological Activity

Description Levodopa is the precursor to the neurotransmitters dopamine, norepinephrine (noradrenaline), and epinephrine (adrenaline), used to treat Parkinson's symptoms.
Targets
Dopamine receptor [1]
In vitro

Levodopa produces at 25-200 μM concentrations a dose-dependent reduction of 3H-DA uptake in foetal rat midbrain cultures. Levodopa results in a decrease in the number of viable cells and tyrosine hydroxylase (TH) positive neurones, plus disruption of the overall neuritic network. [1] Levodopa induces dyskinesia in the absence of dopamine by excessive inhibition of neurons of the putamen-globus pallidus (GPe) projection and subsequent disinhibition of the globus pallidus (GPe). Levodopa results in a decrease in cytochrome oxidase messenger RNA expression in the globus pallidus (GPi). [2]

In vivo Levodopa elicits the development of a variety of abnormal movements in monkeys with parkinsonism induced by the neurotoxin MPTP. Levodopa administrations result in an ectopic induction of the dopamine D3receptor expression in the CdPu in 6-OHDA-lesioned rats. [3] Levodopa (50 mg/kg) increases anandamide concentrations throughout thebasal ganglia via activation of dopamine D1/D2 receptors in intact rats. Levodopa produces increasingly severe oro-lingual involuntary movements which are attenuated by the cannabinoid agonist R(+)-WIN55,212-2 (1 mg/kg) in lesioned rats. [4] Levodopa administration reverses the up-regulation of D2 dopamine receptors seen in severely lesioned rats provided evidence that Levodopa reaches a biologically active concentration at the basal ganglia. [5]

Protocol

Solubility (25°C)

In vitro DMSO Insoluble
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 197.19
Formula

C9H11NO4

CAS No. 59-92-7
Storage powder
in solvent
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04379778 Not yet recruiting Other: Aerobic exercise Parkinson Disease University of Aarhus July 2020 Not Applicable
NCT04182399 Not yet recruiting Drug: Zonisamide Capsules Parkinson Disease Ain Shams University April 1 2020 Not Applicable
NCT04369430 Recruiting Drug: AKST4290|Drug: Placebo Parkinson Disease Alkahest Inc. January 16 2020 Phase 2
NCT04232969 Recruiting Drug: Exenatide extended release 2mg (Bydureon) Parkinson''s Disease University College London January 20 2020 Phase 3
NCT04305002 Recruiting Drug: Exenatide|Drug: Placebo Parkinson Disease Center for Neurology Stockholm|Karolinska Institutet January 21 2020 Phase 2

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID