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CAS No. 59-92-7
Levodopa is the precursor to the neurotransmitters dopamine, norepinephrine (noradrenaline), and epinephrine (adrenaline), used to treat Parkinson's symptoms.
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(A) A focused screening of Aβ generation in response to levodopa, piribedil, bromocriptine or carbidopa at indicated concentrations in SK-N-SH cells. Data are mean ± s.e.m., n = 3-4. *p < 0.05; ***p < 0.001 versus the control of each group.
PLoS ONE, 12(3), e0173240. Levodopa purchased from Selleck.
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|Description||Levodopa is the precursor to the neurotransmitters dopamine, norepinephrine (noradrenaline), and epinephrine (adrenaline), used to treat Parkinson's symptoms.|
Levodopa produces at 25-200 μM concentrations a dose-dependent reduction of 3H-DA uptake in foetal rat midbrain cultures. Levodopa results in a decrease in the number of viable cells and tyrosine hydroxylase (TH) positive neurones, plus disruption of the overall neuritic network.  Levodopa induces dyskinesia in the absence of dopamine by excessive inhibition of neurons of the putamen-globus pallidus (GPe) projection and subsequent disinhibition of the globus pallidus (GPe). Levodopa results in a decrease in cytochrome oxidase messenger RNA expression in the globus pallidus (GPi). 
|In vivo||Levodopa elicits the development of a variety of abnormal movements in monkeys with parkinsonism induced by the neurotoxin MPTP. Levodopa administrations result in an ectopic induction of the dopamine D3receptor expression in the CdPu in 6-OHDA-lesioned rats.  Levodopa (50 mg/kg) increases anandamide concentrations throughout thebasal ganglia via activation of dopamine D1/D2 receptors in intact rats. Levodopa produces increasingly severe oro-lingual involuntary movements which are attenuated by the cannabinoid agonist R(+)-WIN55,212-2 (1 mg/kg) in lesioned rats.  Levodopa administration reverses the up-regulation of D2 dopamine receptors seen in severely lesioned rats provided evidence that Levodopa reaches a biologically active concentration at the basal ganglia. |
-  Mena MA, et al. Neuroreport, 1993, 4(4), 438-440.
-  Garcia-Effron G, et al. J Antimicrob Chemother, 2004, 53(6), 1086-1089.
-  Bordet R, et al. Proc Natl Acad Sci U S A, 1997, 94(7), 3363-3367.
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT04976127||Not yet recruiting||Drug: Talineuren||Parkinson Disease||InnoMedica Schweiz AG||October 2021||Phase 1|
|NCT04735627||Not yet recruiting||Device: Levodopameter||Parkinson Disease||University of California San Diego||July 2021||Not Applicable|
|NCT04379778||Recruiting||Other: Aerobic exercise||Parkinson Disease||University of Aarhus||March 1 2021||Not Applicable|
|NCT04616521||Not yet recruiting||Procedure: Deep brain stimulation||Parkinson Disease||Ruijin Hospital|Huashan Hospital|Shanghai Tongji Hospital Tongji University School of Medicine|The First Affiliated Hospital with Nanjing Medical University|First Affiliated Hospital Sun Yat-Sen University|The First Affiliated Hospital of Guangzhou Medical University|West China Hospital|Second Affiliated Hospital of Soochow University|Tianjin Huanhu Hospital|Guangzhou General Hospital of Guangzhou Military Command|The Affiliated Hospital of Xuzhou Medical University||January 1 2021||Not Applicable|
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