Penfluridol

For research use only.

Catalog No.S4151 Synonyms: TLP-607

Penfluridol Chemical Structure

Molecular Weight(MW): 523.97

Penfluridol is a highly potent, first generation diphenylbutylpiperidine antipsychotic.

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Biological Activity

Description Penfluridol is a highly potent, first generation diphenylbutylpiperidine antipsychotic.
Targets
Dopamine receptor [1]
(Cell-free assay)
1.6 μM(Ki)
In vitro

Penfluridol is a neuroleptic drug with long duration of action, which is able to relieve both negative and positive symptoms of schizophrenia. Penfluridol inhibits the binding of dopamine to dopamine receptor with Ki of 1.6 μM. It exerts its antipsychotic activity by blocking the dopamine projections in the limbic system and in mesocortical area. [1] Penfluridol selectively inhibits the binding of [3H]nitrendipine to rat cerebral cortical membrane fraction and also competitively antagonizes potassium-induced calcium-dependent contractions in rat vas deferens. Penfluridol (10 μM) inhibits the contractile response of isolated rings of rabbit thoracic aorta to NE and KCl, and inhibits calcium influx during either NE or KCl stimulation. [2]

Protocol

Solubility (25°C)

In vitro DMSO 100 mg/mL (190.85 mM)
Ethanol 100 mg/mL (190.85 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 523.97
Formula

C28H27ClF5NO

CAS No. 26864-56-2
Storage powder
in solvent
Synonyms TLP-607
Smiles OC1(CCN(CCCC(C2=CC=C(F)C=C2)C3=CC=C(F)C=C3)CC1)C4=CC(=C(Cl)C=C4)C(F)(F)F

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Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

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Dilution Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Dopamine Receptor Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID