Penfluridol

Catalog No.S4151 Synonyms: TLP-607

For research use only.

Penfluridol (TLP-607) is a highly potent, first generation diphenylbutylpiperidine antipsychotic.

Penfluridol Chemical Structure

CAS No. 26864-56-2

Selleck's Penfluridol has been cited by 1 Publication

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Biological Activity

Description Penfluridol (TLP-607) is a highly potent, first generation diphenylbutylpiperidine antipsychotic.
Targets
Dopamine receptor [1]
(Cell-free assay)
1.6 μM(Ki)
In vitro

Penfluridol is a neuroleptic drug with long duration of action, which is able to relieve both negative and positive symptoms of schizophrenia. Penfluridol inhibits the binding of dopamine to dopamine receptor with Ki of 1.6 μM. It exerts its antipsychotic activity by blocking the dopamine projections in the limbic system and in mesocortical area. [1] Penfluridol selectively inhibits the binding of [3H]nitrendipine to rat cerebral cortical membrane fraction and also competitively antagonizes potassium-induced calcium-dependent contractions in rat vas deferens. Penfluridol (10 μM) inhibits the contractile response of isolated rings of rabbit thoracic aorta to NE and KCl, and inhibits calcium influx during either NE or KCl stimulation. [2]

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 523.97
Formula

C28H27ClF5NO

CAS No. 26864-56-2
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1CN(CCC1(C2=CC(=C(C=C2)Cl)C(F)(F)F)O)CCCC(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F

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