Name: Penfluridol
Brand: Selleck Chemicals
SKU: S4151
Availability: InStock
Rating: 5 (5 reviews)

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Quality Control

Batch: Purity: >97%

Cited in Nature Medicine for its top-tier quality
COA
Datasheet
SDS

Cited in Nature Medicine for its top-tier quality
COA
NMR
Datasheet
SDS

97

Related Targets	Adrenergic Receptor AChR 5-HT Receptor COX Calcium Channel Histamine Receptor GABA Receptor TRP Channel Cholinesterase (ChE) GluR
Other Dopamine Receptor Inhibitors	MPTP Hydrochloride Trifluoperazine Trifluoperazine 2HCl SCH-23390 hydrochloride Domperidone SKF38393 HCl Sulpiride Azaperone C-DIM12 ONC206

Solubility

In vitro
Batch:

DMSO : 100 mg/mL (190.85 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 100 mg/mL

Water : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	5.000mg/ml (9.54mM)
	5% DMSO 1 95% Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	5.000mg/ml (9.54mM)
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

%

% Tween 80

% ddH₂O

% DMSO

+

%

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	523.97	Formula	C₂₈H₂₇ClF₅NO	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	26864-56-2	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	TLP-607,R-16341			Smiles	C1CN(CCC1(C2=CC(=C(C=C2)Cl)C(F)(F)F)O)CCCC(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F

Mechanism of Action

Targets/IC₅₀/Ki	Dopamine receptor (Cell-free assay) 1.6 μM(Ki)
In vitro	Penfluridol is a neuroleptic drug with long duration of action, which is able to relieve both negative and positive symptoms of schizophrenia. It inhibits the binding of dopamine to dopamine receptor with K_i of 1.6 μM. This compound exerts its antipsychotic activity by blocking the dopamine projections in the limbic system and in mesocortical area. The chemical selectively inhibits the binding of [³H]nitrendipine to rat cerebral cortical membrane fraction and also competitively antagonizes potassium-induced calcium-dependent contractions in rat vas deferens. This agent (10 μM) inhibits the contractile response of isolated rings of rabbit thoracic aorta to NE and KCl, and inhibits calcium influx during either NE or KCl stimulation.
References	[1] https://pubmed.ncbi.nlm.nih.gov/3854/ [2] https://pubmed.ncbi.nlm.nih.gov/2579392/

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Penfluridol Dopamine Receptor antagonist

Chemical Structure

Molecular Weight: 523.97