For research use only.

Catalog No.S4151 Synonyms: TLP-607

1 publication

Penfluridol Chemical Structure

CAS No. 26864-56-2

Penfluridol (TLP-607) is a highly potent, first generation diphenylbutylpiperidine antipsychotic.

Selleck's Penfluridol has been cited by 1 publication

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Biological Activity

Description Penfluridol (TLP-607) is a highly potent, first generation diphenylbutylpiperidine antipsychotic.
Dopamine receptor [1]
(Cell-free assay)
1.6 μM(Ki)
In vitro

Penfluridol is a neuroleptic drug with long duration of action, which is able to relieve both negative and positive symptoms of schizophrenia. Penfluridol inhibits the binding of dopamine to dopamine receptor with Ki of 1.6 μM. It exerts its antipsychotic activity by blocking the dopamine projections in the limbic system and in mesocortical area. [1] Penfluridol selectively inhibits the binding of [3H]nitrendipine to rat cerebral cortical membrane fraction and also competitively antagonizes potassium-induced calcium-dependent contractions in rat vas deferens. Penfluridol (10 μM) inhibits the contractile response of isolated rings of rabbit thoracic aorta to NE and KCl, and inhibits calcium influx during either NE or KCl stimulation. [2]


Solubility (25°C)

In vitro DMSO 100 mg/mL (190.85 mM)
Ethanol 100 mg/mL (190.85 mM)
Water Insoluble

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Chemical Information

Molecular Weight 523.97


CAS No. 26864-56-2
Storage powder
in solvent
Synonyms TLP-607
Smiles C1CN(CCC1(C2=CC(=C(C=C2)Cl)C(F)(F)F)O)CCCC(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID