Pramipexole 2HCl Monohydrate
Catalog No.S2011
Molecular Weight(MW): 302.26
Pramipexole 2HCl Monohydrateis a novel non-ergoline dopamine (DA) agonist, used to treat Parkinson's disease.
Purity & Quality Control
Choose Selective Dopamine Receptor Inhibitors
Biological Activity
| Description | Pramipexole 2HCl Monohydrateis a novel non-ergoline dopamine (DA) agonist, used to treat Parkinson's disease. | ||||
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| Targets |
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| In vitro |
Pramipexole, a chemically novel dopamine agonist used for the treatment of Parkinson's disease symptoms, possesses antioxidant activity and is neuroprotective toward substantia nigral dopamine neurons in hypoxic-ischemic and methamphetamine models. Pramipexole reduces the levels of oxygen radicals produced by methylpyridinium ion (MPP+) both when incubated with SH-SY5Y cells and when perfused into rat striatum. Pramipexole also exhibits a concentration-dependent inhibition of opening of the mitochondrial transition pore induced by calcium and phosphate or MPP+. [1] Pramipexole decreases the levels of dopamine metabolites dose dependently, whereas striatal dopamine levels remains unchanged. [2] Pramipexole acts in both of these models to reduce the elevated dopamine turnover and the associated elevation in hydroxyl radical production secondary to increased MAO activity that could be responsible for oxidative damage to the nigrostriatal neurons. [3] Pramipexole (4-100 mM) significantly attenuates DA- or L-DOPA-induced cytotoxicity and apoptosis, an action which is not blocked by D3 antagonist U-99194 A or D2 antagonist raclopride. Pramipexole also protects MES 23.5 cells from hydrogen peroxide-induced cytotoxicity in a dose-dependent manner. Pramipexole can effectively inhibit the formation of melanin, an end product resulting from DA or L-DOPA oxidation in cell-free system. [4] |
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| In vivo | Pramipexole (0.001-1 mg/kg s.c.) reduces exploratory locomotor activity in mice. [2] Pramipexole (1 mg/kg, p.o.) is able to significantly reduce the increased DA turnover, but by only 16%. [3] |
Protocol
Solubility (25°C)
| In vitro | Water | 60 mg/mL (198.5 mM) |
|---|---|---|
| DMSO | 41 mg/mL (135.64 mM) | |
| Ethanol | Insoluble |
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Information
| Molecular Weight | 302.26 |
|---|---|
| Formula | C10H17N3S.2HCl.H2O |
| CAS No. | 191217-81-9 |
| Storage | powder |
| in solvent | |
| Synonyms | N/A |
Bio Calculators
Molarity Calculator
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Dilution Calculator
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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
Molecular Weight Calculator
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Molarity Calculator
Clinical Trial Information
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT03842709 | Not yet recruiting | Chronic Pain | University of New Mexico|University of New Mexico Clinical and Translational Science Center | March 2019 | Early Phase 1 |
| NCT03842709 | Not yet recruiting | Chronic Pain | University of New Mexico|University of New Mexico Clinical and Translational Science Center | March 2019 | Early Phase 1 |
| NCT03817554 | Not yet recruiting | Restless Legs Syndrome | Dong Jie|Peking University First Hospital | February 1 2019 | Phase 4 |
| NCT03817554 | Not yet recruiting | Restless Legs Syndrome | Dong Jie|Peking University First Hospital | February 1 2019 | Phase 4 |
| NCT03845387 | Recruiting | Parkinson Disease | Kissei Pharmaceutical Co. Ltd. | February 2019 | Phase 2 |
| NCT03845387 | Recruiting | Parkinson Disease | Kissei Pharmaceutical Co. Ltd. | February 2019 | Phase 2 |
Tech Support
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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