Pramipexole 2HCl Monohydrate

Catalog No.S2011

Pramipexole 2HCl Monohydrate  Chemical Structure

Molecular Weight(MW): 302.26

Pramipexole 2HCl Monohydrateis a novel non-ergoline dopamine (DA) agonist, used to treat Parkinson's disease.

Size Price Stock Quantity  
In DMSO USD 130 In stock
USD 60 In stock
USD 187 In stock
USD 370 In stock
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Biological Activity

Description Pramipexole 2HCl Monohydrateis a novel non-ergoline dopamine (DA) agonist, used to treat Parkinson's disease.
Targets
D2S Receptor [1] D2L Receptor [1] D3 receptor [1] D4 receptor [1]
In vitro

Pramipexole, a chemically novel dopamine agonist used for the treatment of Parkinson's disease symptoms, possesses antioxidant activity and is neuroprotective toward substantia nigral dopamine neurons in hypoxic-ischemic and methamphetamine models. Pramipexole reduces the levels of oxygen radicals produced by methylpyridinium ion (MPP+) both when incubated with SH-SY5Y cells and when perfused into rat striatum. Pramipexole also exhibits a concentration-dependent inhibition of opening of the mitochondrial transition pore induced by calcium and phosphate or MPP+. [1] Pramipexole decreases the levels of dopamine metabolites dose dependently, whereas striatal dopamine levels remains unchanged. [2] Pramipexole acts in both of these models to reduce the elevated dopamine turnover and the associated elevation in hydroxyl radical production secondary to increased MAO activity that could be responsible for oxidative damage to the nigrostriatal neurons. [3] Pramipexole (4-100 mM) significantly attenuates DA- or L-DOPA-induced cytotoxicity and apoptosis, an action which is not blocked by D3 antagonist U-99194 A or D2 antagonist raclopride. Pramipexole also protects MES 23.5 cells from hydrogen peroxide-induced cytotoxicity in a dose-dependent manner. Pramipexole can effectively inhibit the formation of melanin, an end product resulting from DA or L-DOPA oxidation in cell-free system. [4]

In vivo Pramipexole (0.001-1 mg/kg s.c.) reduces exploratory locomotor activity in mice. [2] Pramipexole (1 mg/kg, p.o.) is able to significantly reduce the increased DA turnover, but by only 16%. [3]

Protocol

Solubility (25°C)

In vitro Water 60 mg/mL (198.5 mM)
DMSO 41 mg/mL (135.64 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 302.26
Formula

C10H17N3S.2HCl.H2O

CAS No. 191217-81-9
Storage powder
in solvent
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03842709 Not yet recruiting Chronic Pain University of New Mexico|University of New Mexico Clinical and Translational Science Center March 2019 Early Phase 1
NCT03842709 Not yet recruiting Chronic Pain University of New Mexico|University of New Mexico Clinical and Translational Science Center March 2019 Early Phase 1
NCT03817554 Not yet recruiting Restless Legs Syndrome Dong Jie|Peking University First Hospital February 1 2019 Phase 4
NCT03817554 Not yet recruiting Restless Legs Syndrome Dong Jie|Peking University First Hospital February 1 2019 Phase 4
NCT03845387 Recruiting Parkinson Disease Kissei Pharmaceutical Co. Ltd. February 2019 Phase 2
NCT03845387 Recruiting Parkinson Disease Kissei Pharmaceutical Co. Ltd. February 2019 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Dopamine Receptor Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID