Pramipexole 2HCl Monohydrate

For research use only.

Catalog No.S2011

1 publication

Pramipexole 2HCl Monohydrate  Chemical Structure

CAS No. 191217-81-9

Pramipexole 2HCl Monohydrateis a novel non-ergoline dopamine (DA) agonist, used to treat Parkinson's disease.

Selleck's Pramipexole 2HCl Monohydrate has been cited by 1 publication

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Biological Activity

Description Pramipexole 2HCl Monohydrateis a novel non-ergoline dopamine (DA) agonist, used to treat Parkinson's disease.
D2S Receptor [1] D2L Receptor [1] D3 receptor [1] D4 receptor [1]
In vitro

Pramipexole, a chemically novel dopamine agonist used for the treatment of Parkinson's disease symptoms, possesses antioxidant activity and is neuroprotective toward substantia nigral dopamine neurons in hypoxic-ischemic and methamphetamine models. Pramipexole reduces the levels of oxygen radicals produced by methylpyridinium ion (MPP+) both when incubated with SH-SY5Y cells and when perfused into rat striatum. Pramipexole also exhibits a concentration-dependent inhibition of opening of the mitochondrial transition pore induced by calcium and phosphate or MPP+. [1] Pramipexole decreases the levels of dopamine metabolites dose dependently, whereas striatal dopamine levels remains unchanged. [2] Pramipexole acts in both of these models to reduce the elevated dopamine turnover and the associated elevation in hydroxyl radical production secondary to increased MAO activity that could be responsible for oxidative damage to the nigrostriatal neurons. [3] Pramipexole (4-100 mM) significantly attenuates DA- or L-DOPA-induced cytotoxicity and apoptosis, an action which is not blocked by D3 antagonist U-99194 A or D2 antagonist raclopride. Pramipexole also protects MES 23.5 cells from hydrogen peroxide-induced cytotoxicity in a dose-dependent manner. Pramipexole can effectively inhibit the formation of melanin, an end product resulting from DA or L-DOPA oxidation in cell-free system. [4]

In vivo Pramipexole (0.001-1 mg/kg s.c.) reduces exploratory locomotor activity in mice. [2] Pramipexole (1 mg/kg, p.o.) is able to significantly reduce the increased DA turnover, but by only 16%. [3]


Solubility (25°C)

In vitro Water 60 mg/mL (198.5 mM)
DMSO 41 mg/mL (135.64 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 302.26


CAS No. 191217-81-9
Storage powder
in solvent
Synonyms N/A
Smiles CCCNC1CCC2=C(C1)SC(=N2)N.O.Cl.Cl

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03683225 Unknown status Combination Product: CTC-413 Idiopathic Parkinson Disease Chase Therapeutics Corporation April 1 2019 Phase 2
NCT03642964 Active not recruiting Drug: CTC-501 Major Depressive Disorder (MDD) Chase Therapeutics Corporation September 10 2018 Phase 2
NCT02101138 Unknown status Drug: Dexpramipexole Hypereosinophilic Syndrome National Institute of Allergy and Infectious Diseases (NIAID)|Knopp Biosciences|National Institutes of Health Clinical Center (CC) March 14 2014 Phase 2
NCT01733199 Completed Other: questionnaires Parkinson''s Disease|Secondary Behavioural Addiction Nantes University Hospital October 2012 Phase 4
NCT01607034 Completed Drug: Dexpramipexole Healthy Volunteers Knopp Biosciences June 2012 Phase 1
NCT01597310 Completed Drug: Warfarin|Drug: Dexpramipexole Healthy Volunteers Knopp Biosciences May 2012 Phase 1

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID