Domperidone

For research use only.

Catalog No.S2461

Domperidone  Chemical Structure

CAS No. 57808-66-9

Domperidone is an oral dopamine D2 receptor antagonist, used to treat nausea and vomiting.

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Biological Activity

Description Domperidone is an oral dopamine D2 receptor antagonist, used to treat nausea and vomiting.
Targets
Dopamine D2 receptor [1]
In vitro

Domperidone (a D2R antagonist) inhibits Equilibrative NT1 (ENT1) activity more in the presence than in the absence of Bromocriptine and displays an IC50 value lower than that of Bromocriptine or Ergovaline in Madin-Darby bovine kidney (MDBK) cells. [1]

In vivo Domperidone (0.1 mg/kg) results in a significant decrease in feeding behavior and stimulation of basal metabolism, but has no effect on locomotor activity of rats in a Phenomaster system. [2] Domperidone (1.1 mg/kg and 5.5 mg/kg, oral) significantly increases laminar microvascular blood flow (LMBF) in horses, compared with baseline values, beginning 4 hours after administration, and this effect persisted for at least 8 hours. Domperidone (0.2 mg/kg, i.v.) significantly increases laminar microvascular blood flow (LMBF) in horses, compared with baseline values, at 10 and 12 hours after administration. [3] Domperidone can ameliorate deleterious reproductive effects and reduce weight gain associated with fescue toxicosis in heifers. [4] Domperidone-treated mares have shorter gestation duration and foaled closer to their expected parturition date than did control mares. Domperidone-treated mares have higher Mammary gland scores and serum prolactin concentration. [5] Domperidone (5 mg/kg, oral) increases peak plasma acetaminophen concentration and area under the curve in rats, indicating increased gastric emptying. Domperidone decreases the dopamine-induced contractile activity of midjejunal longitudinal muscle strips in rats. [6]

Protocol

Solubility (25°C)

In vitro DMSO 48 mg/mL (112.69 mM)
Ethanol 1 mg/mL (2.34 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 425.91
Formula

C22H24ClN5O2

CAS No. 57808-66-9
Storage powder
in solvent
Synonyms N/A
Smiles C1CN(CCC1N2C3=C(C=C(C=C3)Cl)NC2=O)CCCN4C5=CC=CC=C5NC4=O

In vivo Formulation Calculator (Clear solution)

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Molarity Calculator

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Dilution Calculator

Dilution Calculator

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Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04653584 Enrolling by invitation -- Parkinson Disease Assistance Publique - Hôpitaux de Paris January 1 2021 --
NCT03837067 Completed -- Parkinson''s Disease Assistance Publique - Hôpitaux de Paris July 17 2018 --
NCT01710462 Withdrawn Drug: Pantoprazole + Domperidone|Drug: Pantozol® Gastroesophageal Reflux Disease Eurofarma Laboratorios S.A. August 2013 Phase 3
NCT01907633 Completed Drug: No intervention Death Sudden Cardiac Janssen Research & Development LLC December 2011 --
NCT01844622 Completed Other: Domperidone Digestive System Disease Mt. Sinai Medical Center Miami December 2007 Not Applicable

Tech Support

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Dopamine Receptor Signaling Pathway Map

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