Pramipexole dihydrochloride

For research use only.

Catalog No.S5066 Synonyms: SND919

Pramipexole dihydrochloride Chemical Structure

CAS No. 104632-25-9

Pramipexole dihydrochloride (SND919) is a dopamine agonist of the non-ergoline class indicated for treating Parkinson's disease (PD) and restless legs syndrome (RLS) with Ki values of 3.9 nM, 2.2 nM, 0.5 nM and 5.1 nM for D2S receptor, D2L receptor, D3 receptor and D4 receptor.

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Biological Activity

Description Pramipexole dihydrochloride (SND919) is a dopamine agonist of the non-ergoline class indicated for treating Parkinson's disease (PD) and restless legs syndrome (RLS) with Ki values of 3.9 nM, 2.2 nM, 0.5 nM and 5.1 nM for D2S receptor, D2L receptor, D3 receptor and D4 receptor.
Targets
D3 receptor [1]
(Cell-free)
D2L Receptor [1]
(Cell-free)
D2S Receptor [1]
(Cell-free)
D4 receptor [1]
(Cell-free)
0.5 nM(Ki) 2.2 nM(Ki) 3.9 nM(Ki) 5.1 nM(Ki)
In vivo In mice, pramipexole (0.001-1 mg/kg s.c.) reduced exploratory locomotor activity. In rats with unilateral striatal lesions, only weak ipsilateral rotation was produced by pramipexole at the highest dose. However, in rats with unilateral lesions of the medial forebrain bundle, pramipexole potently induced contralateral circling (ED50 0.026 mg/kg s.c). In the N-mcthyl-4-phenyl-l,2,3,6 tetrahydropyridine (MPTP) monkey model, pramipexole also had potent stimulatory effects[2]. Pramipexole is, at least in part, transported across the BBB by an organic cation-sensitive transporter. The pramipexole transport is pH-dependent, but sodium- and membrane potential-independent[3].

Protocol

Animal Research:

[2]

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  • Animal Models: Male mice
  • Dosages: 0.001-1 mg/kg
  • Administration: p.o.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 56 mg/mL (197.0 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 284.25
Formula

C10H17N3S.2HCl

CAS No. 104632-25-9
Storage powder
in solvent
Synonyms SND919
Smiles CCCNC1CCC2=C(C1)SC(=N2)N.Cl.Cl

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