Home Neuronal Signaling Dopamine Receptor agonist Pramipexole dihydrochloride For research use only.

Pramipexole dihydrochloride

Synonyms: SND919

Pramipexole dihydrochloride (SND919) is a dopamine agonist of the non-ergoline class indicated for treating Parkinson's disease (PD) and restless legs syndrome (RLS) with Ki values of 3.9 nM, 2.2 nM, 0.5 nM and 5.1 nM for D2S receptor, D2L receptor, D3 receptor and D4 receptor.

Pramipexole dihydrochloride Chemical Structure

Pramipexole dihydrochloride Chemical Structure

CAS: 104632-25-9

Purity & Quality Control

Batch: S506601 DMSO] 56 mg/mL] false] ] ] false] ] ] false Purity: 98%
98

Pramipexole dihydrochloride Related Products

Signaling Pathway

Dopamine Receptor Signaling Pathways

Dopamine Receptor Signaling Pathway

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Biological Activity

Description Pramipexole dihydrochloride (SND919) is a dopamine agonist of the non-ergoline class indicated for treating Parkinson's disease (PD) and restless legs syndrome (RLS) with Ki values of 3.9 nM, 2.2 nM, 0.5 nM and 5.1 nM for D2S receptor, D2L receptor, D3 receptor and D4 receptor.
Targets
D3 receptor [1]
(Cell-free)		 D2L Receptor [1]
(Cell-free)		 D2S Receptor [1]
(Cell-free)		 D4 receptor [1]
(Cell-free)
0.5 nM(Ki) 2.2 nM(Ki) 3.9 nM(Ki) 5.1 nM(Ki)
In Vivo
In vivo In mice, pramipexole (0.001-1 mg/kg s.c.) reduced exploratory locomotor activity. In rats with unilateral striatal lesions, only weak ipsilateral rotation was produced by pramipexole at the highest dose. However, in rats with unilateral lesions of the medial forebrain bundle, pramipexole potently induced contralateral circling (ED50 0.026 mg/kg s.c). In the N-mcthyl-4-phenyl-l,2,3,6 tetrahydropyridine (MPTP) monkey model, pramipexole also had potent stimulatory effects[2]. Pramipexole is, at least in part, transported across the BBB by an organic cation-sensitive transporter. The pramipexole transport is pH-dependent, but sodium- and membrane potential-independent[3].
Animal Research Animal Models Male mice
Dosages 0.001-1 mg/kg
Administration p.o.

Chemical Information & Solubility

Molecular Weight 284.25 Formula

C10H17N3S.2HCl
CAS No. 104632-25-9 SDF --
Smiles CCCNC1CCC2=C(C1)SC(=N2)N.Cl.Cl
Storage (From the date of receipt)

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DMSO : 56 mg/mL ( (197.0 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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