lurasidone

Catalog No.S5714 Synonyms: SM-13496

lurasidone Chemical Structure

Molecular Weight(MW): 492.68

Lurasidone is a second-generation antipsychotic agent that exhibits full antagonism at dopamine D2 and serotonin 5-HT2A receptors with binding affinities Ki = 1 nM and Ki = 0.5 nM, respectively. It also has high affinity for serotonin 5-HT7 receptors (Ki = 0.5 nM), partial agonist activity at 5-HT1A receptors (Ki = 6.4 nM) and lacks affinity for histamine H1 and muscarinic M1 receptors.

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Biological Activity

Description Lurasidone is a second-generation antipsychotic agent that exhibits full antagonism at dopamine D2 and serotonin 5-HT2A receptors with binding affinities Ki = 1 nM and Ki = 0.5 nM, respectively. It also has high affinity for serotonin 5-HT7 receptors (Ki = 0.5 nM), partial agonist activity at 5-HT1A receptors (Ki = 6.4 nM) and lacks affinity for histamine H1 and muscarinic M1 receptors.
Targets
5-HT2A [1]
(Cell-free assay)
5-HT7 receptor [1]
(Cell-free assay)
D2 receptor [1]
(Cell-free assay)
5-HT1A receptor [1]
(Cell-free assay)
0.5 nM(Ki) 0.5 nM(Ki) 1 nM(Ki) 6.4 nM(Ki)
In vitro

Lurasidone is a new atypical antipsychotic in the benzoisothiazoles class of chemicals. Like most second-generation antipsychotics it is a full antagonist at dopamine D2 and serotonin 5-HT2A receptors, and is a partial agonist at 5-HT1A receptors. It has much greater affinity for 5-HT7 subtype receptors than other atypical antipsychotics. Lurasidone also has high affinity for the 5-HT1A subtype, α2c-adrenergic receptors and low affinity for α1-adrenergic receptors. It has minimal affinity for 5-HT2C receptors and negligible affinity for histamine H1 and muscarinic receptors[2].

In vivo Lurasidone is rapidly absorbed, reaching peak concentrations within 1.5–3 hours (tmax) after single and multiple oral doses. Once absorbed, it extensively distributes in tissues and rapidly enters the CNS. Lurasidone has high binding to human plasma albumin and alpha-1-glycoprotein (≥99%)[2]. Long-term treatment of schizophrenia with lurasidone has been shown to reduce the risk of relapse. The elimination half-life of lurasidone is about 20-40 h. Mean Cmax and area under the curve (AUC) for lurasidone were approximately threefold and twofold greater, respectively, in a comparison of administration with food v. fasting. Lurasidone absorption is independent of food fat content. Lurasidone is metabolised primarily via CYP3A4[1]. In animal studies, lurasidone penetrated the placental barrier and distributed into the fetus, and was excreted in milk during lactation[2].

Protocol

Solubility (25°C)

In vitro DMSO 7 mg/mL (14.2 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 492.68
Formula

C28H36N4O2S

CAS No. 367514-87-2
Storage powder
in solvent
Synonyms SM-13496

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03396068 Not yet recruiting Bipolar Depression|Suicidal Ideation NeuroRx Inc.|Target Health Inc.|Bracket Inc.|Statistics Collaborative Inc. January 1 2019 Phase 2|Phase 3
NCT03395392 Not yet recruiting Bipolar Depression|Suicidal Ideation NeuroRx Inc.|Target Health Inc.|Bracket Inc.|Statistics Collaborative Inc. January 1 2019 Phase 2|Phase 3
NCT03396068 Not yet recruiting Bipolar Depression|Suicidal Ideation NeuroRx Inc.|Target Health Inc.|Bracket Inc.|Statistics Collaborative Inc. January 1 2019 Phase 2|Phase 3
NCT03395392 Not yet recruiting Bipolar Depression|Suicidal Ideation NeuroRx Inc.|Target Health Inc.|Bracket Inc.|Statistics Collaborative Inc. January 1 2019 Phase 2|Phase 3
NCT03402152 Recruiting Bipolar Depression|Suicidal Ideation NeuroRx Inc.|Target Health Inc. November 1 2018 Phase 2|Phase 3
NCT03402152 Recruiting Bipolar Depression|Suicidal Ideation NeuroRx Inc.|Target Health Inc. November 1 2018 Phase 2|Phase 3

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID