Home Neuronal Signaling Dopamine Receptor antagonist Paliperidone Palmitate

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Paliperidone Palmitate Dopamine Receptor antagonist

Cat.No.S5624

Paliperidone Palmitate (9-hydroxyrisperidone palmitate) is a palmitate ester of paliperidone, which is a dopamine antagonist and 5-HT2A antagonist of the atypical antipsychotic class.
Paliperidone Palmitate Dopamine Receptor antagonist Chemical Structure

Chemical Structure

Molecular Weight: 664.89

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability Specificity

Quality Control

Batch: S562401 Ethanol]3 mg/mL]false]DMSO]1 mg/mL]false]Water]Insoluble]false Purity: 99.06%
99.06

Chemical Information, Storage & Stability

Molecular Weight 664.89 Formula

C39H57FN4O4

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 199739-10-1 -- Storage of Stock Solutions

Synonyms 9-hydroxyrisperidone palmitate Smiles CCCCCCCCCCCCCCCC(=O)OC1CCCN2C1=NC(=C(C2=O)CCN3CCC(CC3)C4=NOC5=C4C=CC(=C5)F)C

Solubility

In vitro
Batch:

Ethanol : 3 mg/mL

DMSO : 1 mg/mL (1.5 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02532842 Completed
Schizophrenia
Janssen Pharmaceutica N.V. Belgium
 July 2015 --
NCT01584466 Withdrawn
Schizophrenia
University of Maryland Baltimore
 January 2014 Not Applicable
NCT01926912 Completed
Schizophrenia
Janssen-Cilag International NV
 May 2013 --
NCT01211704 Withdrawn
Bipolar Disorder
University of Miami|Ortho-McNeil Inc.
 October 2010 Phase 4
NCT01051531 Completed
Schizophrenia
Johnson & Johnson Pte Ltd
 April 2010 Phase 3

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