- D1 receptor
- D2 receptor
- D3 receptor
- D5 receptor
- D4 receptor
DAT Selective Inhibitors | Modulators
|Catalog No.||Product Name||Information||Selective / Pan||IC50 / Ki|
Benztropine is a dopamine transporter (DAT) inhibitor with IC50 of 118 nM.
|Selective||DAT, IC50: 118 nM|
MPP+ iodide (N-Methyl-4-Phenylpyridinium Iodide), the metabolite of a neurotoxin MPTP, causes symptom of Parkinson's disease (PD) in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ induces autophagic cell death in SH-SY5Y cells. MPP+ induces dopamine transporter (DAT) externalization in dopaminergic (DA) neurons, but internalization of serotonin transporter (SERT) in serotonergic (5-HT) neurons.
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