Quetiapine

For research use only.

Catalog No.S5741

Quetiapine Chemical Structure

Molecular Weight(MW): 383.51

Quetiapine is an atypical antipsychotic used for the treatment of schizophrenia, bipolar disorder, and major depressive disorder.Quetiapine is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. Quetiapine is a dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor. Quetiapine have moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.23, 5.74, 7.54, 5.55.

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Biological Activity

Description Quetiapine is an atypical antipsychotic used for the treatment of schizophrenia, bipolar disorder, and major depressive disorder.Quetiapine is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. Quetiapine is a dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor. Quetiapine have moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.23, 5.74, 7.54, 5.55.

Protocol

References

Solubility (25°C)

In vitro DMSO 77 mg/mL (200.77 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 383.51
Formula

C21H25N3O2S

CAS No. 111974-69-7
Storage powder
in solvent
Synonyms N/A
Smiles OCCOCCN1CCN(CC1)C2=NC3=CC=CC=C3SC4=C2C=CC=C4

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04229875 Recruiting Other: CAG Bipolar Bipolar Disorder Mental Health Services in the Capital Region Denmark|Maria Faurholt-Jepsen MD DMSc|The Mental Health Services in the Capital Region of Denmark January 13 2020 Not Applicable
NCT03654378 Withdrawn -- Pregnancy Northwestern University|University of Illinois at Chicago August 1 2018 --

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5-HT Receptor Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID