Home Neuronal Signaling Dopamine Receptor agonist Fenoldopam mesylate

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Fenoldopam mesylate Dopamine Receptor agonist

Cat.No.S4618

Fenoldopam (SKF 82526, Corlopam) is a selective dopamine-1 receptor (DA1) agonist with natriuretic/diuretic properties. It lowers blood pressure through arteriolar vasodilation.
Fenoldopam mesylate Dopamine Receptor agonist Chemical Structure

Chemical Structure

Molecular Weight: 401.86

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Chemical Information, Storage & Stability

Molecular Weight 401.86 Formula

C16H16ClNO3.CH4O3S

 Storage (From the date of receipt)
CAS No. 67227-57-0 Download SDF Storage of Stock Solutions

Synonyms SKF 82526 (mesylate), Fenoldopam methanesulfonate, Corlopam mesylate Smiles CS(=O)(=O)O.C1CNCC(C2=CC(=C(C(=C21)Cl)O)O)C3=CC=C(C=C3)O

Solubility

In vitro
Batch:

DMSO : 80 mg/mL (199.07 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Mechanism of Action

Targets/IC50/Ki
D1 receptor [1]
In vivo
Fenoldopam (20 μg/kg) induced a marked decrease in systolic blood pressure, diastolic blood pressure and heart rate[1].
References

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