Prochlorperazine dimaleate salt

For research use only.

Catalog No.S4631 Synonyms: Prochlorperazin, Compazine, Capazine, Stemetil

1 publication

Prochlorperazine dimaleate salt  Chemical Structure

CAS No. 84-02-6

Prochlorperazine dimaleate (Prochlorperazin, Compazine, Capazine, Stemetil) is a dopamine (D2) receptor antagonist.

Selleck's Prochlorperazine dimaleate salt has been cited by 1 publication

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Biological Activity

Description Prochlorperazine dimaleate (Prochlorperazin, Compazine, Capazine, Stemetil) is a dopamine (D2) receptor antagonist.
Targets
D2 receptor [1]
()
In vitro

Prochlorperazine down-regulates cyclin E2 and reduces cell proliferation in MCF-7 cells that are resistant to tamoxifen. It has the potential to impact on estrogen receptor (ER) function and alter response to endocrine therapy[2].

In vivo Prochlorperazine is showed to be able to induce antinociception in mice. prochlorperazine-treated mice show a complete integrity of motor co-ordination on the rota-rod test, normal spontaneous motility, as well as exploratory behaviour as revealed by the hole-board test. The antinociceptive effect of prochlorperazine appears to be due to the antagonism of D2 receptors since the increase of the pain threshold induced by the investigated compound is prevented by pretreatment with the D2 agonist quinpirole[1].

Protocol

Cell Research:[2]
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  • Cell lines: BT474 cells
  • Concentrations: 5 μM
  • Incubation Time: 2 or 5 days
  • Method: Cells are treated 5 μM of prochlorperazine for 5 days and cell proliferation is measured by methylene blue staining or for 2 days and cyclin E2 mRNA levels are measured by qPCR.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 74 mg/mL warmed (122.09 mM)
Water Insoluble
Ethanol '2 mg/mL warmed

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 606.09
Formula

C20H24ClN3S.C8H8O8

CAS No. 84-02-6
Storage powder
in solvent
Synonyms Prochlorperazin, Compazine, Capazine, Stemetil
Smiles CN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)Cl.C(=CC(=O)O)C(=O)O.C(=CC(=O)O)C(=O)O

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID