Home Neuronal Signaling Dopamine Receptor antagonist Prochlorperazine dimaleate salt For research use only.

Prochlorperazine dimaleate salt

Prochlorperazine dimaleate salt is a dopamine (D2) receptor antagonist.

Prochlorperazine dimaleate salt Chemical Structure

Prochlorperazine dimaleate salt Chemical Structure

CAS: 84-02-6

Selleck's Prochlorperazine dimaleate salt has been cited by 3 publications

Purity & Quality Control

Batch: Purity: 99.83%
99.83

Prochlorperazine dimaleate salt Related Products

Signaling Pathway

Dopamine Receptor Signaling Pathways

Dopamine Receptor Signaling Pathway

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Biological Activity

Description Prochlorperazine dimaleate salt is a dopamine (D2) receptor antagonist.
Targets
D2 receptor [1]
In vitro
In vitro Prochlorperazine down-regulates cyclin E2 and reduces cell proliferation in MCF-7 cells that are resistant to tamoxifen. It has the potential to impact on estrogen receptor (ER) function and alter response to endocrine therapy[2].
Cell Research Cell lines BT474 cells
Concentrations 5 μM
Incubation Time 2 or 5 days
Method Cells are treated 5 μM of prochlorperazine for 5 days and cell proliferation is measured by methylene blue staining or for 2 days and cyclin E2 mRNA levels are measured by qPCR.
In Vivo
In vivo Prochlorperazine is showed to be able to induce antinociception in mice. prochlorperazine-treated mice show a complete integrity of motor co-ordination on the rota-rod test, normal spontaneous motility, as well as exploratory behaviour as revealed by the hole-board test. The antinociceptive effect of prochlorperazine appears to be due to the antagonism of D2 receptors since the increase of the pain threshold induced by the investigated compound is prevented by pretreatment with the D2 agonist quinpirole[1].

Chemical Information & Solubility

Molecular Weight 606.09 Formula

C20H24ClN3S.C8H8O8
CAS No. 84-02-6 SDF Download Prochlorperazine dimaleate salt SDF
Smiles CN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)Cl.C(=CC(=O)O)C(=O)O.C(=CC(=O)O)C(=O)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 27 mg/mL ( (44.54 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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