Prochlorperazine dimaleate salt

Catalog No.S4631 Synonyms: Prochlorperazin, Compazine, Capazine, Stemetil

For research use only.

Prochlorperazine dimaleate (Prochlorperazin, Compazine, Capazine, Stemetil) is a dopamine (D2) receptor antagonist.

Prochlorperazine dimaleate salt  Chemical Structure

CAS No. 84-02-6

Selleck's Prochlorperazine dimaleate salt has been cited by 1 Publication

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Biological Activity

Description Prochlorperazine dimaleate (Prochlorperazin, Compazine, Capazine, Stemetil) is a dopamine (D2) receptor antagonist.
Targets
D2 receptor [1]
()
In vitro

Prochlorperazine down-regulates cyclin E2 and reduces cell proliferation in MCF-7 cells that are resistant to tamoxifen. It has the potential to impact on estrogen receptor (ER) function and alter response to endocrine therapy[2].

In vivo Prochlorperazine is showed to be able to induce antinociception in mice. prochlorperazine-treated mice show a complete integrity of motor co-ordination on the rota-rod test, normal spontaneous motility, as well as exploratory behaviour as revealed by the hole-board test. The antinociceptive effect of prochlorperazine appears to be due to the antagonism of D2 receptors since the increase of the pain threshold induced by the investigated compound is prevented by pretreatment with the D2 agonist quinpirole[1].

Protocol (from reference)

Cell Research:[2]
  • Cell lines: BT474 cells
  • Concentrations: 5 μM
  • Incubation Time: 2 or 5 days
  • Method: Cells are treated 5 μM of prochlorperazine for 5 days and cell proliferation is measured by methylene blue staining or for 2 days and cyclin E2 mRNA levels are measured by qPCR.

Solubility (25°C)

In vitro

DMSO 74 mg/mL warmed
(122.09 mM)
Water Insoluble
Ethanol '2 mg/mL warmed

Chemical Information

Molecular Weight 606.09
Formula

C20H24ClN3S.C8H8O8

CAS No. 84-02-6
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)Cl.C(=CC(=O)O)C(=O)O.C(=CC(=O)O)C(=O)O

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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