Raclopride

Catalog No.E0125

For research use only.

Raclopride is a selective dopamine D2/D3 receptor antagonist that discriminates between dopamine-mediated motor functions. Raclopride binds to D2 and D3 receptors with dissociation constants of between 1.8 nM and 3.5 nM, but has a very low affinity for D4 receptors.

Raclopride Chemical Structure

CAS No. 84225-95-6

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Biological Activity

Description Raclopride is a selective dopamine D2/D3 receptor antagonist that discriminates between dopamine-mediated motor functions. Raclopride binds to D2 and D3 receptors with dissociation constants of between 1.8 nM and 3.5 nM, but has a very low affinity for D4 receptors.
Targets
Dopamine D2 receptor [1]
()
Dopamine D3 receptor [1]
()
1.8 nM(Ki) 3.5 nM(Ki)

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 69 mg/mL
(198.7 mM)
Ethanol 69 mg/mL
(198.7 mM)
Water 1 mg/mL
(2.87 mM)

Chemical Information

Molecular Weight 347.24
Formula

C15H20Cl2N2O3

CAS No. 84225-95-6
Storage 3 years -20°C powder
2 years -80°C in solvent

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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