Home Neuronal Signaling Dopamine Receptor antagonist Raclopride For research use only.

Raclopride

Raclopride is a selective dopamine D2/D3 receptor antagonist that discriminates between dopamine-mediated motor functions. Raclopride binds to D2 and D3 receptors with dissociation constants of between 1.8 nM and 3.5 nM, but has a very low affinity for D4 receptors.

Raclopride Chemical Structure

Raclopride Chemical Structure

CAS: 84225-95-6

Purity & Quality Control

Batch: E012501 DMSO] 69 mg/mL] false] Ethanol] 69 mg/mL] false] Water] 1 mg/mL] false Purity: 99.98%
99.98

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Biological Activity

Description Raclopride is a selective dopamine D2/D3 receptor antagonist that discriminates between dopamine-mediated motor functions. Raclopride binds to D2 and D3 receptors with dissociation constants of between 1.8 nM and 3.5 nM, but has a very low affinity for D4 receptors.
Targets
Dopamine D2 receptor [1] Dopamine D3 receptor [1]
1.8 nM(Ki) 3.5 nM(Ki)
In Vivo
In vivo

Raclopride is an antagonist of central dopaminergic D2 receptors, possessing antiaggressive effect of raclopride with very little motor impairment and some increase in exploratory behavior.[2]
Animal Research Animal Models Albino male mice of the OF1 strain
Dosages 0.1, 0.3, or 0.6 mg/kg
Administration i.p.

Chemical Information & Solubility

Molecular Weight 347.24 Formula

C15H20Cl2N2O3
CAS No. 84225-95-6 SDF --
Smiles CCN1CCCC1CNC(=O)C2=C(OC)C(=CC(=C2O)Cl)Cl
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 69 mg/mL ( (198.7 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 69 mg/mL

Water : 1 mg/mL


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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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