Home Neuronal Signaling Dopamine Receptor antagonist Raclopride

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Raclopride Dopamine Receptor antagonist

Cat.No.E0125

Raclopride is a selective dopamine D2/D3 receptor antagonist that discriminates between dopamine-mediated motor functions. This compound binds to D2 and D3 receptors with dissociation constants of between 1.8 nM and 3.5 nM, but has a very low affinity for D4 receptors.
Raclopride Dopamine Receptor antagonist Chemical Structure

Chemical Structure

Molecular Weight: 347.24

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Quality Control

Batch: E012501 DMSO]69 mg/mL]false]Ethanol]69 mg/mL]false]Water]1 mg/mL]false Purity: 99.98%
99.98

Solubility

In vitro
Batch:

DMSO : 69 mg/mL (198.7 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 69 mg/mL

Water : 1 mg/mL

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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Chemical Information, Storage & Stability

Molecular Weight 347.24 Formula

C15H20Cl2N2O3

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 84225-95-6 -- Storage of Stock Solutions

Mechanism of Action

Targets/IC50/Ki
Dopamine D2 receptor
1.8 nM(Ki)
Dopamine D3 receptor
3.5 nM(Ki)
In vivo

Raclopride is an antagonist of central dopaminergic D2 receptors, possessing antiaggressive effect of this compound with very little motor impairment and some increase in exploratory behavior.
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05359887 Recruiting
Obesity
University Medical Center Groningen
 December 1 2022 Not Applicable
NCT03648892 Completed
Obesity|Healthy Volunteers|Overweight
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)|National Institutes of Health Clinical Center (CC)
 September 21 2018 Early Phase 1
NCT02744391 Completed
Major Depressive Disorder|Dysthymia|Depression Not Otherwise Specified|Decreased Processing Speed|Decreased Gait Speed
New York State Psychiatric Institute
 August 24 2016 Phase 4
NCT03026036 Completed
Major Depressive Disorder
Mclean Hospital
 April 2016 --

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