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Raclopride Dopamine Receptor antagonist

Name: Raclopride
Brand: Selleck Chemicals
SKU: E0125
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.E0125

Raclopride is a selective dopamine D2/D3 receptor antagonist that discriminates between dopamine-mediated motor functions. This compound binds to D2 and D3 receptors with dissociation constants of between 1.8 nM and 3.5 nM, but has a very low affinity for D4 receptors.

Chemical Structure

Molecular Weight: 347.24

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Quality Control

Batch: E012501 DMSO]69 mg/mL]false]Ethanol]69 mg/mL]false]Water]1 mg/mL]false Purity: 99.98%

Cited in Nature Medicine for its top-tier quality
COA
SDS/MSDS
Datasheet

99.98

Related Targets	Adrenergic Receptor AChR 5-HT Receptor COX Calcium Channel Histamine Receptor GABA Receptor TRP Channel Cholinesterase (ChE) GluR
Other Dopamine Receptor Inhibitors	MPTP Hydrochloride Trifluoperazine Trifluoperazine 2HCl Penfluridol Rotundine Domperidone Sulpiride Azaperone ONC206 SCH-23390 hydrochloride

Solubility

In vitro
Batch:

DMSO : 69 mg/mL (198.7 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 69 mg/mL

Water : 1 mg/mL

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	3.45mg/ml (9.94mM)	Taking the 1 mL working solution as an example, add 50 μL of 69 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	0.49mg/ml (1.41mM)	Taking the 1 mL working solution as an example, add 50 μL of 9.8 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	347.24	Formula	C₁₅H₂₀Cl₂N₂O₃	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	84225-95-6	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent

Read more about storage stability stock solution CAS number SMILES

Mechanism of Action

Targets/IC₅₀/Ki	Dopamine D2 receptor 1.8 nM(Ki) Dopamine D3 receptor 3.5 nM(Ki)
In vivo	Raclopride is an antagonist of central dopaminergic D2 receptors, possessing antiaggressive effect of this compound with very little motor impairment and some increase in exploratory behavior.
References	[1] https://pubmed.ncbi.nlm.nih.gov/7940991/ [2] https://pubmed.ncbi.nlm.nih.gov/7911581/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2026-07-28)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT07559500	RECRUITING	Alcohol Use Disorder (AUD)	National Institute on Alcohol Abuse and Alcoholism (NIAAA)	2026-05-20	PHASE1
NCT06977308	NOT_YET_RECRUITING	Clinical High Risk for Psychosis (CHR)	New York State Psychiatric Institute	2026-10-01	PHASE1
NCT05282277	RECRUITING	Depression; Psychosis; Anhedonia	University of North Carolina, Chapel Hill	2022-04-20	PHASE4
NCT03190954	COMPLETED	Normal Physiology; Opioid Use Disorders	National Institute on Alcohol Abuse and Alcoholism (NIAAA)	2017-08-17	EARLY_PHASE1
NCT02169310	COMPLETED	Traumatic Brain Injury	National Institute of Neurological Disorders and Stroke (NINDS)	2014-11-18	PHASE1
NCT03637075	COMPLETED	Diabetes Mellitus, Type 2	University Hospital Tuebingen	2017-02-20

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