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Survivin inhibitors

Survivin is a small protein which plays an important role in cell proliferation and cell division because survivin is a component of chromosomal passenger complex including Aurora kinase B. Cyclin D1,TP53, CDK4 and Aurora kinase are all involved in survivin networks at cell division. Survivin is also an inhibitor of apoptosis. STAT3, PI3K, BAX, AIP, NF-κB, Bcl-2, and P38 MAPK are all involved in the survivin anti-apoptotic network. Now survivin is a prognostic marker for cancer, and a target for chemotherapy.

Other Apoptosis Related Inhibitors

Caspase Bcl-2 p53 Ferroptosis PD-1/PD-L1 TNF-alpha MDM2/MDMX KRas IAP ASK
Cat.No. Product Name Information Product Use Citations Product Validations
S1130 Sepantronium Bromide (YM155) Sepantronium Bromide (YM155) is a potent survivin suppressant by inhibiting Survivin promoter activity with IC50 of 0.54 nM in HeLa-SURP-luc and CHO-SV40-luc cells. It does not significantly inhibit SV40 promoter activity, but is observed to slightly inhibit the interaction of Survivin with XIAP. This compound down-regulates survivin and XIAP, modulates autophagy and induces autophagy-dependent DNA damage in breast cancer cells. Phase 2.
Cell Rep Med, 2025, S2666-3791(25)00102-8
Biochim Biophys Acta Mol Basis Dis, 2025, 1871(3):167693
Cancer Res Commun, 2025, 5(6):1018-1033
Verified customer review of Sepantronium Bromide (YM155)
E0108 LQZ-7I LQZ-7I is a novel selectively inhibitor of survivin dimerization with IC50s of 4.8 µM and 3.1 µM in prostate cancer cell lines PC-3 and C4-2, respectively. This compound orally effectively inhibits xenograft tumor growth and induces survivin loss in tumors.
Cancers (Basel), 2025, 17(17)2864
E1713 FL118 FL118(10,11-(Methylenedioxy)-20(S)-camptothecin), a Camptothecin analog, is a potent and orally active inhibitor of Survivin. This compound also selectively and independently inhibits three additional cancer-associated survival genes Mcl-1, XIAP, and cIAP2 in a p53 status-independent manner. It displays potent antitumor activity and can be used in cancer research.
E6484New E1231 E1231 (1-{4-[2-(5-Methylfuran-2-yl)quinoline-4-carbonyl]piperazin-1-yl}ethan-1-one) is a piperazine 1,4-diamide compound and an oral activator of SIRT1 with an EC50 of 0.83μM. It increases cholesterol efflux and decreases lipid accumulation in macrophages. E1231 regulates cholesterol and lipid metabolism in hyperlipidemic golden hamsters, with potential for atherosclerosis treatment.
S5600 Flavokawain A Flavokawain A, extracted from kava, is an apoptotic inducers and anticarcinogenic agent. This compound can down-regulation of antiapoptotic proteins, such as XIAP, survivin, and Bcl-xL, thereby changing the balance between apoptotic and antiapoptotic molecules and then induce cell death in tumor cells.

Signaling Pathway Map