TW-37

For research use only.

Catalog No.S1121

34 publications

TW-37 Chemical Structure

Molecular Weight(MW): 573.7

TW-37 is a novel nonpeptide inhibitor to recombinant Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.29 μM, 1.11 μM and 0.26 μM in cell-free assays, respectively.

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10mM (1mL in DMSO) EUR 143 In stock
EUR 157 In stock
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Selleck's TW-37 has been cited by 34 publications

Purity & Quality Control

Choose Selective Bcl-2 Inhibitors

Biological Activity

Description TW-37 is a novel nonpeptide inhibitor to recombinant Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.29 μM, 1.11 μM and 0.26 μM in cell-free assays, respectively.
Targets
Mcl-1 [1]
(Cell-free assay)
Bcl-2 [1]
(Cell-free assay)
Bcl-xL [1]
(Cell-free assay)
0.26 μM(Ki) 0.29 μM(Ki) 1.11 μM(Ki)
In vitro

TW-37 targets the BH3-binding groove in Bcl-2 where proapoptotic Bcl-2 proteins bind, and shows higher affinity and selectivity for Bcl-2 and Mcl-1 over Bcl-xL with Ki values of 0.29 μM, 0.26 μM and 1.11 μM, respectively. [1] In vitro, TW-37 shows significant anti-proliferative and pro-apoptotic effect in a de novo chemo-resistant WSU-DLCL2 lymphoma cell line and primary cells obtained from a lymphoma patient without effects on normal peripheral blood lymphocytes. [1] TW-37 exhibits the inhibitory effect on both cell growth and cell death in endothelial cell with IC50 of approximately 1.8 μM without effect on the fibroblasts exposed to the same concentration range as the endothelial cells. In addition, TW37 also shows the anti-proliferation effects in MCF-7, LNCaP, and SLK tumor cell lines with the same or lower concentration range than those required to inhibit endothelial cell growth. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human JAR cell MXfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MnzsTY5pcWKrdHnvckBw\iCqdX3hckBLSVJiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{Lk[gcm0> NGPXNVBUSU6JRWK=
human Ca9-22 cell NX7nRm1pT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MoH5TY5pcWKrdHnvckBw\iCqdX3hckBE[TlvMkKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zMlgzKG6P Mo\EV2FPT0WU
human CHL-1 cell MnHOS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MnX0TY5pcWKrdHnvckBw\iCqdX3hckBEUExvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGxMlkhdk1? NIHUXIFUSU6JRWK=
human A549 cell NYPVZXh4T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NYDCcoFjUW6qaXLpeIlwdiCxZjDoeY1idiCDNUS5JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NVQvODlibl2= NFn0eXBUSU6JRWK=
human RKO cell MV;Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MX\Jcohq[mm2aX;uJI9nKGi3bXHuJHJMVyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTF3LkG3JI5O MXnTRW5ITVJ?
human GCIY cell NEflO5pIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MW\Jcohq[mm2aX;uJI9nKGi3bXHuJGdEUVliY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{MD64N{BvVQ>? MWHTRW5ITVJ?
human BHT-101 cell NVnOT3lKT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M3XwcWlvcGmkaYTpc44hd2ZiaIXtZY4hSkiWLUGwNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVIyNjh|IH7N MnjPV2FPT0WU
human Hs-578-T cell NXXkWZYxT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NWPXNnV5UW6qaXLpeIlwdiCxZjDoeY1idiCKcz21O|guXCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJ|LkW5JI5O NHnJfYJUSU6JRWK=
human SK-UT-1 cell NWHPNJU{T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NGjIXm9KdmirYnn0bY9vKG:oIHj1cYFvKFONLWXUMVEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zQC54ODDuUS=> Mn7jV2FPT0WU
human NB7 cell MVPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NWjmUWsyUW6qaXLpeIlwdiCxZjDoeY1idiCQQkegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yPU4zQCCwTR?= MmDMV2FPT0WU
human YKG-1 cell NIrSSYlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NF\xPWdKdmirYnn0bY9vKG:oIHj1cYFvKFmNRz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NlkvPzZibl2= M3G2dnNCVkeHUh?=
human HuH-7 cell MnzGS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NUjHU4dRUW6qaXLpeIlwdiCxZjDoeY1idiCKdVitO{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVMzNjh{IH7N MVXTRW5ITVJ?
human SAS cell NHrJR41Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= MoXOTY5pcWKrdHnvckBw\iCqdX3hckBUSVNiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1|Mz6xPEBvVQ>? MoGzV2FPT0WU
human UACC-62 cell NULF[ngxT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NWLwOHJQUW6qaXLpeIlwdiCxZjDoeY1idiCXQVPDMVYzKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OzRwM{Wgcm0> MnH0V2FPT0WU
human AGS cell NGPSdHVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NG\SeXpKdmirYnn0bY9vKG:oIHj1cYFvKEGJUzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUO3MlU{KG6P MV\TRW5ITVJ?
human SK-MEL-30 cell MX7Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NGL2RZhKdmirYnn0bY9vKG:oIHj1cYFvKFONLV3FUE0{OCClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTN5Lkm3JI5O MnzSV2FPT0WU
human A427 cell MlX1S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NIDCPI5KdmirYnn0bY9vKG:oIHj1cYFvKEF2MkegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME20OE43QSCwTR?= M{f0cXNCVkeHUh?=
human DU-145 cell MkPrS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MXnJcohq[mm2aX;uJI9nKGi3bXHuJGRWNTF2NTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUWyMlE{KG6P MWLTRW5ITVJ?
human HCT-116 cell M{W0TWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NIHBRpRKdmirYnn0bY9vKG:oIHj1cYFvKEiFVD2xNVYh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF02Oi54NjDuUS=> MmDzV2FPT0WU
human A673 cell MUTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M3PnZ2lvcGmkaYTpc44hd2ZiaIXtZY4hSTZ5MzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUWzMlg2KG6P MkfxV2FPT0WU
human SF126 cell M1TMeWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NH3GcXhKdmirYnn0bY9vKG:oIHj1cYFvKFOIMUK2JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OVcvODdibl2= MoC1V2FPT0WU
human SW872 cell MkXmS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NEPDTY1KdmirYnn0bY9vKG:oIHj1cYFvKFOZOEeyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OVgvQSCwTR?= MU\TRW5ITVJ?
human NCI-H1581 cell NYTDTnpYT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NGi2ZpJKdmirYnn0bY9vKG:oIHj1cYFvKE6FST3INVU5OSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTZ5Lk[0JI5O MoXNV2FPT0WU
human SK-MEL-5 cell MlTES5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MoKyTY5pcWKrdHnvckBw\iCqdX3hckBUUy2PRVytOUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVY6NjJ3IH7N M3HDcXNCVkeHUh?=
human CP50-MEL-B cell NXfHdIVbT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M4jDcGlvcGmkaYTpc44hd2ZiaIXtZY4hS1B3MD3NSWwuSiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTZ7LkW5JI5O MUfTRW5ITVJ?
human YH-13 cell M4fkcWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NF23fVNKdmirYnn0bY9vKG:oIHj1cYFvKFmKLUGzJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9O|AvPTlibl2= MlX6V2FPT0WU
human LXF-289 cell MXPHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M{HWVmlvcGmkaYTpc44hd2ZiaIXtZY4hVFiILUK4PUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVczNjh3IH7N MVjTRW5ITVJ?
human MC-IXC cell NY\tS4RUT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MV7Jcohq[mm2aX;uJI9nKGi3bXHuJG1ENUm[QzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUe1MlM{KG6P NHXiXWRUSU6JRWK=
human NB14 cell NFHNfnlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NH24SVRKdmirYnn0bY9vKG:oIHj1cYFvKE6EMUSgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME23Ok41PSCwTR?= MYDTRW5ITVJ?
human HEC-1 cell MYXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NV;ke4htUW6qaXLpeIlwdiCxZjDoeY1idiCKRVOtNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVgyNjN5IH7N NV:2bGcyW0GQR1XS
human U-87-MG cell NEn0XYJIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NYrEenI1UW6qaXLpeIlwdiCxZjDoeY1idiCXLUi3MW1IKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:QDJwMkSgcm0> M1THOHNCVkeHUh?=
human HOS cell NFzN[G5Iem:5dHigbY5pcWKrdHnvckBie3OjeR?= NYX1d3ZiUW6qaXLpeIlwdiCxZjDoeY1idiCKT2OgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME24OE44OSCwTR?= M4j5ZnNCVkeHUh?=
human HUTU-80 cell M4nUWmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NVPIPWdxUW6qaXLpeIlwdiCxZjDoeY1idiCKVWTVMVgxKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:QDdwMEGgcm0> NWCxSVZzW0GQR1XS
human A375 cell NVvCTJlVT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MmLDTY5pcWKrdHnvckBw\iCqdX3hckBCOzd3IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;OEiuPFMhdk1? MnH3V2FPT0WU
human A204 cell NEXCNYxIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3yxW2lvcGmkaYTpc44hd2ZiaIXtZY4hSTJyNDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUm3Mlg1KG6P NX;NU5FxW0GQR1XS
human GB-1 cell NHPWfWxIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NVrqN|NYUW6qaXLpeIlwdiCxZjDoeY1idiCJQj2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PVgvPjlibl2= MX\TRW5ITVJ?
human MDA-MB-231 cell M4LGcGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MWrJcohq[mm2aX;uJI9nKGi3bXHuJG1FSS2PQj2yN|Eh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjFyOEC3JO69VQ>? NF3DRppUSU6JRWK=
human SW982 cell NGDqZoFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M3LuTWlvcGmkaYTpc44hd2ZiaIXtZY4hW1d7OEKgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlEyODdizszN MXfTRW5ITVJ?
human SW756 cell NWP5eZlzT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NHjIZmtKdmirYnn0bY9vKG:oIHj1cYFvKFOZN{W2JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4yOTJ|NjFOwG0> MXHTRW5ITVJ?
human MG-63 cell M1;ZXWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M2nIcGlvcGmkaYTpc44hd2ZiaIXtZY4hVUdvNkOgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlEyOjR6IN88US=> MYHTRW5ITVJ?
human Daoy cell NGG3U3JIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NYjNflhKUW6qaXLpeIlwdiCxZjDoeY1idiCGYX;5JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4yPDB5MzFOwG0> NInhW49USU6JRWK=
human MDA-MB-453 cell MknhS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M4HLe2lvcGmkaYTpc44hd2ZiaIXtZY4hVUSDLV3CMVQ2OyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTBwMUWxPFgh|ryP M4O0dnNCVkeHUh?=
human HT-144 cell MWDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? Ml;YTY5pcWKrdHnvckBw\iCqdX3hckBJXC1zNESgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlE2OjBzIN88US=> M2rBSXNCVkeHUh?=
human LoVo cell NEDVSlBIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NIL2XolKdmirYnn0bY9vKG:oIHj1cYFvKEyxVn:gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlE3ODl|IN88US=> M1vqS3NCVkeHUh?=
human NY cell MorDS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M{PMNGlvcGmkaYTpc44hd2ZiaIXtZY4hVlliY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1yLkG3O|YzKM7:TR?= M37DZ3NCVkeHUh?=
human SW1783 cell NUXCV2N3T3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MYDJcohq[mm2aX;uJI9nKGi3bXHuJHNYOTd6MzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuNlE{ODFizszN NUG5VVNMW0GQR1XS
human A2780 cell M{jwNWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MlXqTY5pcWKrdHnvckBw\iCqdX3hckBCOjd6MDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuNlE5PDZizszN M13DdXNCVkeHUh?=
human MDA-MB-361 cell M4\jW2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MUjJcohq[mm2aX;uJI9nKGi3bXHuJG1FSS2PQj2zOlEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjJ{NkSg{txO MULTRW5ITVJ?
human RPMI-2650 cell MWXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M4TqWGlvcGmkaYTpc44hd2ZiaIXtZY4hWlCPST2yOlUxKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC5{M{izNUDPxE1? NF:wZ49USU6JRWK=

... Click to View More Cell Line Experimental Data

In vivo TW-37 shows a maximum tolerated dose (MTD) of 40 mg/kg for three i.v. injections in severe combined immunodeficient (SCID) mice when given alone, and enhances tumor inhibitory effect of cyclophosphamide-doxorubicin-vincristine-prednisone (CHOP) regimen. [1] TW-37, administrated by i.v. produces the antiangiogenic effect by decreasing the density of functional human microvessels in the severe combined immunodeficient mouse model of human angiogenesis. [2] The combination of TW-37 and MEK inhibitors synergistically block melanoma cell growth in mice by a significant reduction in tumor volume and tumor mass. [3]

Protocol

Kinase Assay:[1]
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Fluorescence polarization-based binding assay for recombinant Bcl-2, Bcl-XL, and Mcl-1 protein :

For this assay, the 21-residue BH3 peptide QEDIIRNIARHLAQVGDSMDR derived from Bid labeled with 6-carboxyfluorescein succinimidyl ester (FAM-Bid) and recombinant proteins derived from human Bcl-2,Bcl-X L,and Mcl-1 are employed. It is determined that FAM-Bid has a Ki of 11 nM to Bcl-2 protein,25 nM to Bcl-XL protein,and 5.7 nM to Mcl-1 protein. The competitive binding assay for Bcl-XL is same as that for Bcl-2 with the following exceptions: 30 nM Bcl-XL protein and 2.5 nM FAM-Bid peptide in the following assay buffer [50 mM Tris-Bis (pH 7.4) and 0.01% bovine gamma-globulin].
Cell Research:[2]
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  • Cell lines: HDMECs
  • Concentrations: 0 - 100 μM
  • Incubation Time: 96 hours
  • Method: The sulforhodamine B (SRB) cytotoxicity assay is used as described. Briefly, optimal cell density for cytotoxicity assay is determined by growth curve analysis. HDMECs are seeded in a 96-well plate and allowed to adhere overnight. Drug or control is diluted in EGM2-MV and layered onto cells, which are allowed to incubate for times as indicated in the figures. Alternatively, HDMECs are coincubated with TW37 and 0 to 100 ng/mL recombinant human VEGF (rhVEGF)165 or 0 to 100 ng/mL recombinant human CXCL8. Cells are fixed on the plates by addition of cold trichloroacetic acid (10% final concentration) and incubation for 1 hour at 4 °C. Cellular protein is stained by addition of 0.4% SRB in 1% acetic acid and incubation at room temperature for 30 minutes. Unbound SRB is removed by washing with 1% acetic acid and the plates are air dried. Bound SRB is resolubilized in 10 mM unbuffered Tris-base and absorbance is determined on a microplate reader at 560 nm. Test results are normalized against initial plating density and drug-free controls. Data are obtained from triplicate wells per condition and are representative of at least three independent experiments
    (Only for Reference)
Animal Research:[3]
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  • Animal Models: Athymic NCr-nu/nu mice bearing SK-Mel-147 melanoma xenografts
  • Dosages: ~40 mg/kg
  • Administration: Administered via i.v. or i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 115 mg/mL (200.45 mM)
Ethanol 4 mg/mL (6.97 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
30% propylene glycol, 5% Tween 80, 65% D5W
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 573.7
Formula

C33H35NO6S

CAS No. 877877-35-5
Storage powder
in solvent
Synonyms N/A
Smiles CC(C)C1=CC=CC=C1CC2=CC(=C(C(=C2O)O)O)C(=O)NC3=CC=C(C=C3)S(=O)(=O)C4=CC=CC=C4C(C)(C)C

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Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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