TW-37

Catalog No.S1121

TW-37 Chemical Structure

Molecular Weight(MW): 573.7

TW-37 is a novel nonpeptide inhibitor to recombinant Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.29 μM, 1.11 μM and 0.26 μM in cell-free assays, respectively.

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In DMSO USD 146 In stock
USD 160 In stock
USD 680 In stock
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Cited by 29 Publications

Purity & Quality Control

Choose Selective Bcl-2 Inhibitors

Biological Activity

Description TW-37 is a novel nonpeptide inhibitor to recombinant Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.29 μM, 1.11 μM and 0.26 μM in cell-free assays, respectively.
Targets
Mcl-1 [1]
(Cell-free assay)
Bcl-2 [1]
(Cell-free assay)
Bcl-xL [1]
(Cell-free assay)
0.26 μM(Ki) 0.29 μM(Ki) 1.11 μM(Ki)
In vitro

TW-37 targets the BH3-binding groove in Bcl-2 where proapoptotic Bcl-2 proteins bind, and shows higher affinity and selectivity for Bcl-2 and Mcl-1 over Bcl-xL with Ki values of 0.29 μM, 0.26 μM and 1.11 μM, respectively. [1] In vitro, TW-37 shows significant anti-proliferative and pro-apoptotic effect in a de novo chemo-resistant WSU-DLCL2 lymphoma cell line and primary cells obtained from a lymphoma patient without effects on normal peripheral blood lymphocytes. [1] TW-37 exhibits the inhibitory effect on both cell growth and cell death in endothelial cell with IC50 of approximately 1.8 μM without effect on the fibroblasts exposed to the same concentration range as the endothelial cells. In addition, TW37 also shows the anti-proliferation effects in MCF-7, LNCaP, and SLK tumor cell lines with the same or lower concentration range than those required to inhibit endothelial cell growth. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human JAR cell MYTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MXfJcohq[mm2aX;uJI9nKGi3bXHuJGpCWiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTJwNjDuUS=> MX\TRW5ITVJ?
human Ca9-22 cell NULIeY9IT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NWLlWFlJUW6qaXLpeIlwdiCxZjDoeY1idiCFYUmtNlIh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0{Njh{IH7N MnnxV2FPT0WU
human CHL-1 cell MknVS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MnrzTY5pcWKrdHnvckBw\iCqdX3hckBEUExvMTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUGxMlkhdk1? NHrSXVlUSU6JRWK=
human A549 cell NGLNSmVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M33Wd2lvcGmkaYTpc44hd2ZiaIXtZY4hSTV2OTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUG0MlA6KG6P MVvTRW5ITVJ?
human RKO cell NUj6T5hrT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= M1zXdmlvcGmkaYTpc44hd2ZiaIXtZY4hWkuRIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MUWuNVchdk1? M{npbnNCVkeHUh?=
human GCIY cell MkP3S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MXTJcohq[mm2aX;uJI9nKGi3bXHuJGdEUVliY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1{MD64N{BvVQ>? M3HPWHNCVkeHUh?=
human BHT-101 cell NEPhbmVIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NIftdZZKdmirYnn0bY9vKG:oIHj1cYFvKEKKVD2xNFEh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zOS56MzDuUS=> NHyxb|JUSU6JRWK=
human Hs-578-T cell M3S5Umdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M4nFTGlvcGmkaYTpc44hd2ZiaIXtZY4hUHNvNUe4MXQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0zOy53OTDuUS=> MlTPV2FPT0WU
human SK-UT-1 cell MlXqS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M{jifGlvcGmkaYTpc44hd2ZiaIXtZY4hW0tvVWStNUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVI5NjZ6IH7N NVLvPZFlW0GQR1XS
human NB7 cell MX\Hdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NF7VTWVKdmirYnn0bY9vKG:oIHj1cYFvKE6ENzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUK5MlI5KG6P NXrFXIYzW0GQR1XS
human YKG-1 cell MmHaS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M3vCOGlvcGmkaYTpc44hd2ZiaIXtZY4hYUuJLUGgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2yPU44PiCwTR?= MX;TRW5ITVJ?
human HuH-7 cell MUXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M4Xob2lvcGmkaYTpc44hd2ZiaIXtZY4hUHWKLUegZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2zNk45OiCwTR?= NVHUcGt7W0GQR1XS
human SAS cell NGH1WVNIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MV3Jcohq[mm2aX;uJI9nKGi3bXHuJHNCWyClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTN|LkG4JI5O NVr6eINnW0GQR1XS
human UACC-62 cell M{LWbmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M1PIXmlvcGmkaYTpc44hd2ZiaIXtZY4hXUGFQz22NkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVM1NjN3IH7N NXHVN49[W0GQR1XS
human AGS cell MVXHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NHW2WGpKdmirYnn0bY9vKG:oIHj1cYFvKEGJUzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUO3MlU{KG6P MWXTRW5ITVJ?
human SK-MEL-30 cell NGDjT3pIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NVn4W2VTUW6qaXLpeIlwdiCxZjDoeY1idiCVSz3NSWwuOzBiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD1|Nz65O{BvVQ>? MVzTRW5ITVJ?
human A427 cell Mkf6S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M3fVZWlvcGmkaYTpc44hd2ZiaIXtZY4hSTR{NzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUS0MlY6KG6P M{\UNHNCVkeHUh?=
human DU-145 cell MXrHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? MoTVTY5pcWKrdHnvckBw\iCqdX3hckBFXS1zNEWgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME21Nk4yOyCwTR?= Ml6wV2FPT0WU
human HCT-116 cell Mn;mS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MoPGTY5pcWKrdHnvckBw\iCqdX3hckBJS1RvMUG2JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9OVIvPjZibl2= NW\RN|dNW0GQR1XS
human A673 cell NETHTXRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MmHnTY5pcWKrdHnvckBw\iCqdX3hckBCPjd|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;NUOuPFUhdk1? MojEV2FPT0WU
human SF126 cell NF;scmdIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NV7WfY11UW6qaXLpeIlwdiCxZjDoeY1idiCVRkGyOkBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVU4NjB5IH7N NXfxbHVHW0GQR1XS
human SW872 cell MoK0S5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? MUfJcohq[mm2aX;uJI9nKGi3bXHuJHNYQDd{IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;NUiuPUBvVQ>? NVfKfYpbW0GQR1XS
human NCI-H1581 cell M4SyU2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MWTJcohq[mm2aX;uJI9nKGi3bXHuJG5EUS2KMUW4NUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVY4NjZ2IH7N M3zVWnNCVkeHUh?=
human SK-MEL-5 cell NHzkfYRIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NEfNV4hKdmirYnn0bY9vKG:oIHj1cYFvKFONLV3FUE02KGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:PjlwMkWgcm0> NUHCbmhQW0GQR1XS
human CP50-MEL-B cell M{jKbmdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M1;rN2lvcGmkaYTpc44hd2ZiaIXtZY4hS1B3MD3NSWwuSiClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTZ7LkW5JI5O M1jWWXNCVkeHUh?=
human YH-13 cell NHu1XFlIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MX3Jcohq[mm2aX;uJI9nKGi3bXHuJHlJNTF|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;N{CuOVkhdk1? MYnTRW5ITVJ?
human LXF-289 cell M3PU[2dzd3e2aDDpcohq[mm2aX;uJIF{e2G7 M4XZd2lvcGmkaYTpc44hd2ZiaIXtZY4hVFiILUK4PUBk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVczNjh3IH7N M125RnNCVkeHUh?=
human MC-IXC cell NG\XNYtIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MV3Jcohq[mm2aX;uJI9nKGi3bXHuJG1ENUm[QzDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUe1MlM{KG6P NGCwUmtUSU6JRWK=
human NB14 cell Mk\yS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? M4HrXGlvcGmkaYTpc44hd2ZiaIXtZY4hVkJzNDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUe2MlQ2KG6P NIjGZ|FUSU6JRWK=
human HEC-1 cell Mn;jS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NF3BOHlKdmirYnn0bY9vKG:oIHj1cYFvKEiHQz2xJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PFEvOzdibl2= M2LUPHNCVkeHUh?=
human U-87-MG cell MYnHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NFz0Xm1KdmirYnn0bY9vKG:oIHj1cYFvKFVvOEetUWch[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF05Oi5{NDDuUS=> MlPEV2FPT0WU
human HOS cell MmfKS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NVzFRYk4UW6qaXLpeIlwdiCxZjDoeY1idiCKT2OgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME24OE44OSCwTR?= NF;scFdUSU6JRWK=
human HUTU-80 cell NV;m[YJxT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MkPBTY5pcWKrdHnvckBw\iCqdX3hckBJXVSXLUiwJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9PFcvODFibl2= MorEV2FPT0WU
human A375 cell M2CxZWdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 MmT4TY5pcWKrdHnvckBw\iCqdX3hckBCOzd3IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;OEiuPFMhdk1? M2TlenNCVkeHUh?=
human A204 cell MYfHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M2WzWGlvcGmkaYTpc44hd2ZiaIXtZY4hSTJyNDDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUm3Mlg1KG6P M3q2SnNCVkeHUh?=
human GB-1 cell NYixelNNT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= MYTJcohq[mm2aX;uJI9nKGi3bXHuJGdDNTFiY3XscEBoem:5dHigbY4h[SClZXzsJJZq[WKrbHn0fUBie3OjeTygTWM2OD17OD62PUBvVQ>? MWPTRW5ITVJ?
human MDA-MB-231 cell MYTHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M376R2lvcGmkaYTpc44hd2ZiaIXtZY4hVUSDLV3CMVI{OSClZXzsJIdzd3e2aDDpckBiKGOnbHygeoli[mmuaYT5JIF{e2G7LDDJR|UxRTBwMUC4NFch|ryP NWPQR2dyW0GQR1XS
human SW982 cell MUDHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? NEHWbIdKdmirYnn0bY9vKG:oIHj1cYFvKFOZOUiyJINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4yOTB5IN88US=> MmHsV2FPT0WU
human SW756 cell MkDVS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NF7JSGRKdmirYnn0bY9vKG:oIHj1cYFvKFOZN{W2JINmdGxiZ4Lve5RpKGmwIHGgZ4VtdCC4aXHibYxqfHliYYPzZZktKEmFNUC9NE4yOTJ|NjFOwG0> M1\kc3NCVkeHUh?=
human MG-63 cell NWjYNZVbT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NWficHNvUW6qaXLpeIlwdiCxZjDoeY1idiCPRz22N{Bk\WyuIHfyc5d1cCCrbjDhJINmdGxidnnhZoltcXS7IHHzd4F6NCCLQ{WwQVAvOTF{NEig{txO NU\NcmxpW0GQR1XS
human Daoy cell NIXiRXFIem:5dHigbY5pcWKrdHnvckBie3OjeR?= MlT2TY5pcWKrdHnvckBw\iCqdX3hckBF[W:7IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD6xOFA4OyEQvF2= MkOwV2FPT0WU
human MDA-MB-453 cell NFPzeGpIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NYPEdGtDUW6qaXLpeIlwdiCxZjDoeY1idiCPRFGtUWIuPDV|IHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD6xOVE5QCEQvF2= NETyR3NUSU6JRWK=
human HT-144 cell M{exOGdzd3e2aDDpcohq[mm2aX;uJIF{e2G7 NVfpeVd6UW6qaXLpeIlwdiCxZjDoeY1idiCKVD2xOFQh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjF3MkCxJO69VQ>? MmHUV2FPT0WU
human LoVo cell NEjDbotIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NF30NXpKdmirYnn0bY9vKG:oIHj1cYFvKEyxVn:gZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlE3ODl|IN88US=> MVXTRW5ITVJ?
human NY cell NWO0SGJHT3Kxd4ToJIlvcGmkaYTpc44h[XO|YYm= NWXMWWx1UW6qaXLpeIlwdiCxZjDoeY1idiCQWTDj[YxtKGe{b4f0bEBqdiCjIHPlcIwhfmmjYnnsbZR6KGG|c3H5MEBKSzVyPUCuNVc4PjJizszN NYO1VGZCW0GQR1XS
human SW1783 cell NGfLT5ZIem:5dHigbY5pcWKrdHnvckBie3OjeR?= NWLrSYxsUW6qaXLpeIlwdiCxZjDoeY1idiCVV{G3PFMh[2WubDDndo94fGhiaX6gZUBk\WyuII\pZYJqdGm2eTDhd5NigSxiSVO1NF0xNjJzM{CxJO69VQ>? NHjJO4tUSU6JRWK=
human A2780 cell MYjHdo94fGhiaX7obYJqfGmxbjDhd5NigQ>? M2L2V2lvcGmkaYTpc44hd2ZiaIXtZY4hSTJ5OECgZ4VtdCCpcn;3eIghcW5iYTDj[YxtKH[rYXLpcIl1gSCjc4PhfUwhUUN3ME2wMlIyQDR4IN88US=> MXvTRW5ITVJ?
human MDA-MB-361 cell MlHaS5Jwf3SqIHnubIljcXSrb36gZZN{[Xl? NX7mc|JRUW6qaXLpeIlwdiCxZjDoeY1idiCPRFGtUWIuOzZzIHPlcIwh\3Kxd4ToJIlvKGFiY3XscEB3cWGkaXzpeJkh[XO|YYmsJGlEPTB;MD6yNlY1KM7:TR?= Mmm2V2FPT0WU
human RPMI-2650 cell NGnVR2FIem:5dHigbY5pcWKrdHnvckBie3OjeR?= M4TNcWlvcGmkaYTpc44hd2ZiaIXtZY4hWlCPST2yOlUxKGOnbHyg[5Jwf3SqIHnuJIEh[2WubDD2bYFjcWyrdImgZZN{[XluIFnDOVA:OC5{M{izNUDPxE1? NUL4UVFwW0GQR1XS

... Click to View More Cell Line Experimental Data

In vivo TW-37 shows a maximum tolerated dose (MTD) of 40 mg/kg for three i.v. injections in severe combined immunodeficient (SCID) mice when given alone, and enhances tumor inhibitory effect of cyclophosphamide-doxorubicin-vincristine-prednisone (CHOP) regimen. [1] TW-37, administrated by i.v. produces the antiangiogenic effect by decreasing the density of functional human microvessels in the severe combined immunodeficient mouse model of human angiogenesis. [2] The combination of TW-37 and MEK inhibitors synergistically block melanoma cell growth in mice by a significant reduction in tumor volume and tumor mass. [3]

Protocol

Kinase Assay:[1]
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Fluorescence polarization-based binding assay for recombinant Bcl-2, Bcl-XL, and Mcl-1 protein :

For this assay, the 21-residue BH3 peptide QEDIIRNIARHLAQVGDSMDR derived from Bid labeled with 6-carboxyfluorescein succinimidyl ester (FAM-Bid) and recombinant proteins derived from human Bcl-2,Bcl-X L,and Mcl-1 are employed. It is determined that FAM-Bid has a Ki of 11 nM to Bcl-2 protein,25 nM to Bcl-XL protein,and 5.7 nM to Mcl-1 protein. The competitive binding assay for Bcl-XL is same as that for Bcl-2 with the following exceptions: 30 nM Bcl-XL protein and 2.5 nM FAM-Bid peptide in the following assay buffer [50 mM Tris-Bis (pH 7.4) and 0.01% bovine gamma-globulin].
Cell Research:[2]
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  • Cell lines: HDMECs
  • Concentrations: 0 - 100 μM
  • Incubation Time: 96 hours
  • Method: The sulforhodamine B (SRB) cytotoxicity assay is used as described. Briefly, optimal cell density for cytotoxicity assay is determined by growth curve analysis. HDMECs are seeded in a 96-well plate and allowed to adhere overnight. Drug or control is diluted in EGM2-MV and layered onto cells, which are allowed to incubate for times as indicated in the figures. Alternatively, HDMECs are coincubated with TW37 and 0 to 100 ng/mL recombinant human VEGF (rhVEGF)165 or 0 to 100 ng/mL recombinant human CXCL8. Cells are fixed on the plates by addition of cold trichloroacetic acid (10% final concentration) and incubation for 1 hour at 4 °C. Cellular protein is stained by addition of 0.4% SRB in 1% acetic acid and incubation at room temperature for 30 minutes. Unbound SRB is removed by washing with 1% acetic acid and the plates are air dried. Bound SRB is resolubilized in 10 mM unbuffered Tris-base and absorbance is determined on a microplate reader at 560 nm. Test results are normalized against initial plating density and drug-free controls. Data are obtained from triplicate wells per condition and are representative of at least three independent experiments
    (Only for Reference)
Animal Research:[3]
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  • Animal Models: Athymic NCr-nu/nu mice bearing SK-Mel-147 melanoma xenografts
  • Formulation: TW-37 is resuspended in 1:1 Tween 80/ethanol (diluted 10-fold in 0.9% saline before use).
  • Dosages: ~40 mg/kg
  • Administration: Administered via i.v. or i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 115 mg/mL (200.45 mM)
Ethanol 4 mg/mL (6.97 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
30% propylene glycol, 5% Tween 80, 65% D5W
For best results, use promptly after mixing.
30 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 573.7
Formula

C33H35NO6S

CAS No. 877877-35-5
Storage powder
in solvent
Synonyms N/A

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  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Bcl-2 Signaling Pathway Map

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