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Catalog No.	Product Name	Information	Product Use Citations
S7024	Stattic	Stattic, the first nonpeptidic small molecule, potently inhibits STAT3 activation and nuclear translocation with IC50 of 5.1 μM in cell-free assays, highly selectivity over STAT1. Stattic induces apoptosis.	Mol Cancer, 2025, 24(1):122 J Clin Invest, 2025, 135(11)e181243 Acta Pharm Sin B, 2025, 15(3):1430-1446
S1155	NSC 74859 (S3I-201)	NSC 74859 (S3I-201) shows potent inhibition of STAT3 DNA-binding activity with IC50 of 86 μM in cell-free assays, and low activity towards STAT1 and STAT5.	Front Immunol, 2025, 16:1550405 Oncogenesis, 2025, 14(1):16 Commun Biol, 2025, 8(1):471
S1491	Fludarabine	Fludarabine is a STAT1 activation inhibitor which causes a specific depletion of STAT1 protein (and mRNA) but not of other STATs. Also a DNA synthesis inhibitor in vascular smooth muscle cells. Fludarabine induces apoptosis.	Cell Rep, 2025, 44(4):115559 JCI Insight, 2025, e181885 iScience, 2025, 28(3):111950
S1014	Bosutinib	Bosutinib is a novel, dual Src/Abl inhibitor with IC50 of 1.2 nM and 1 nM in cell-free assays, respectively. Bosutinib also effectively decreases the activity of PI3K/AKT/mTOR, MAPK/ERK and JAK/STAT3 signaling pathways by blocking the phosphorylation levels of p-ERK, p-S6, and p-STAT3. Bosutinib promotes autophagy.	Blood Adv, 2025, bloodadvances.2024015364 Virulence, 2025, 16(1):2489751 Elife, 2024, 12RP92324
S2796	WP1066	WP1066 is a novel inhibitor of JAK2 and STAT3 with IC50 of 2.30 μM and 2.43 μM in HEL cells; shows activity to JAK2, STAT3, STAT5, and ERK1/2 not JAK1 and JAK3. WP1066 induces apoptosis. Phase 1.	Nat Commun, 2024, 15(1):1987 Cancer Cell Int, 2024, 24(1):60 CNS Neurosci Ther, 2024, 30(9):e70017
S1396	Resveratrol	Resveratrol has a wide spectrum of targets including cyclooxygenases(i.e. COX, IC50=1.1 μM), lipooxygenases（LOX, IC50=2.7 μM）, kinases, sirtuins and other proteins. It has anti-cancer, anti-inflammatory, blood-sugar-lowering and other beneficial cardiovascular effects. Resveratrol induces mitophagy/autophagy and autophagy-dependent apoptosis.	Front Immunol, 2025, 16:1515605 Int J Mol Sci, 2025, 26(2)851 Biochem Biophys Res Commun, 2024, 723:150186
S2285	Cryptotanshinone (Tanshinone C)	Cryptotanshinone (Tanshinone C) is a STAT3 inhibitor with IC50 of 4.6 μM in a cell-free assay, strongly inhibits phosphorylation of STAT3 Tyr705, with a small effect on STAT3 Ser727, but none against STAT1 nor STAT5. Cryptotanshinone induces ROS-dependent autophagy and mitochondria-mediated apoptosis.	Bone Joint Res, 2024, 13(4):137-148 J Med Virol, 2023, 95(11):e29230 Microbiol Spectr, 2023, e0493222.
S2824	TPCA-1	TPCA-1 (GW683965) is an inhibitor of IKK-2 with IC50 of 17.9 nM in a cell-free assay, inhibits NF-κB pathway, exhibits 22-fold selectivity over IKK-1. TPCA-1 is also an inhibitor of STAT3 and enhances apoptosis.	EMBO J, 2025, 10.1038/s44318-025-00412-5 PLoS Pathog, 2025, 21(1):e1012915 Sci Adv, 2025, 11(4):eadq2395
S7337	SH-4-54	SH-4-54 is a potent STAT inhibitor with K_D of 300 nM and 464 nM for STAT3 and STAT5, respectively.	Nat Commun, 2024, 15(1):1835 Cell Signal, 2024, S0898-6568(24)00170-0 J Immunol, 2024, 213(4):419-434
S8605	C188-9	C188-9 (TTI 101) is a potent inhibitor of STAT3 that binds to STAT3 with high affinity (KD=4.7±0.4 nM). C188-9 is well tolerated in mice, shows good oral bioavailability, and is concentrated in tumors.	Exp Eye Res, 2025, 253:110280 Sci Adv, 2025, 11(4):eadq2395 J Nanobiotechnology, 2024, 22(1):362
S3030	Niclosamide	Niclosamide can inhibit DNA replication and inhibit STAT3 with IC50 of 0.7 μM in a cell-free assay. Niclosamide selectively inhibited the phosphorylation of STAT3 and had no obvious inhibition against the activation of other homologues (e.g., STAT1 and STAT5).	Pharmaceutics, 2025, 17(3)332 Cytokine, 2025, 186:156850 Int J Biol Sci, 2024, 20(7):2440-2453
S7769	BP-1-102	BP-1-102 is a potent, orally bioavailable and selective STAT3 inhibitor, binds Stat3 with an affinity Kd of 504 nM and blocks Stat3-phospho-tyrosine (pTyr) peptide interactions and Stat3 activation at 4-6.8 μM.	Cancers (Basel), 2025, 17(2)267 Theranostics, 2024, 14(3):1224-1240 Cell Rep, 2024, 43(2):113751
S7977	Napabucasin (BBI608)	Napabucasin (BBI608) is an orally available Stat3 and cancer cell stemness inhibitor.	Cancers (Basel), 2025, 17(3)477 Nat Commun, 2024, 15(1):1754 J Transl Med, 2024, 22(1):1125
S7501	HO-3867	HO-3867, an analog of curcumin, is a selective STAT3 inhibitor that inhibits its phosphorylation, transcription, and DNA binding without affecting the expression of other active STATs. HO-3867 induces apoptosis.	Int J Biol Sci, 2025, 21(5):1914-1931 Biomedicines, 2023, 11(3)694 Evid Based Complement Alternat Med, 2023, 2023:8378581
S4182	Nifuroxazide	Nifuroxazide is a cell-permeable and orally available nitrofuran-based antidiarrheal agent that effectively suppresses the activation of cellular STAT1/3/5 transcription activity with IC50 of 3 μM against IL-6-induced STAT3 activation in U3A cells.	Nat Commun, 2025, 16(1):2159 Cell Death Dis, 2024, 15(1):70 Cell Oncol (Dordr), 2024, 10.1007/s13402-024-00989-9
S8685	AS1517499	AS1517499 is a novel and potent STAT6 inhibitor with an IC50 value of 21 nM.	J Clin Invest, 2025, e169152 Arthritis Res Ther, 2025, 27(1):12 Nature, 2024, 625(7996):778-787
S9015	Homoharringtonine (HHT)	Homoharringtonine (HHT), a plant alkaloid with antitumor properties, inhibits protein translation by preventing the initial elongation step of protein synthesis via an interaction with the ribosomal A-site. Homoharringtonine reversiblely inhibits IL-6-induced STAT3 Tyrosine 705 phosphorylation and reduced anti-apoptotic proteins expression.	Nat Commun, 2025, 16(1):617 iScience, 2024, 27(10):110862 Vet Comp Oncol, 2024, 10.1111/vco.12999
S2265	Artesunate	Artesunate is a part of the artemisinin group of agents with an IC50 of < 5 μM for small cell lung carcinoma cell line H69. It is a potential inhibitor of STAT-3 and exhibits selective cytotoxicity of cancer cells over normal cells in vitro; A potent inhibitor of EXP1.	Phytomedicine, 2024, 136:156333 Virus Res, 2024, 349:199448 Int Immunopharmacol, 2023, 119:110205
S6784	STAT5-IN-1	STAT5-IN-1 is a potent and selective STAT5 inhibitor with IC50 of 47 μM for STAT5β isoform.	J Exp Clin Cancer Res, 2025, 44(1):68 Proc Natl Acad Sci U S A, 2024, 121(11):e2317658121 Cell Mol Life Sci, 2024, 81(1):152
S7951	Ochromycinone (STA-21)	Ochromycinone (STA-21) is a selective STAT3 inhibitor.	Cell Rep, 2023, 42(2):112137 Neural Regen Res, 2023, 18(6):1325-1331 Biochem Pharmacol, 2021, 192:114688
S8561	HJC0152	HJC0152 is a signal transducer and activator of transcription 3 (STAT3) inhibitor with remarkably improved aqueous solubility.	Cell Mol Immunol, 2025, 10.1038/s41423-025-01301-x Cancer Discov, 2023, 13(7):1616-1635 Cancer Commun (Lond), 2023, 43(5):562-581
S9664	Colivelin	Colivelin (CLN) is a brain-penetrant neuroprotective peptide with potent long-term capacity against Aβ deposition, neuronal apoptosis, and synaptic plasticity deficits in neurodegenerative disease. Colivelin is an activator of STAT3.	J Clin Invest, 2025, 135(11)e181243 Stem Cell Res Ther, 2025, 16(1):40 Int J Mol Med, 2025, 55(3)42
S8197	APTSTAT3-9R	APTSTAT3-9R is a specific STAT3-binding peptide with addition of a cell-penetrating motif. The treatment of APTSTAT3-9R in various types of cancer cells blocks STAT3 phosphorylation and reduces expression of STAT targets.	Hepatology, 2024, 10.1097/HEP.0000000000001003 Biophys Rep (N Y), 2023, 3(2):100108 Sci Rep, 2022, 12(1):7
S0818	STAT3-IN-1	STAT3-IN-1 (compound 7d) is an excellent, selective and orally active inhibitor of STAT3 with IC50 of 1.82 μM and 2.14 μM in HT29 and MDA-MB 231 cells, respectively. STAT3-IN-1 induces apoptosis of tumor cells.	J Exp Clin Cancer Res, 2025, 44(1):68 Front Immunol, 2024, 15:1470907 JCI Insight, 2023, 8(22)e164672
S0986	SC-1	SC-1 (1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea, STAT3-IN-7), a Sorafenib analogue and potently inhibits the phosphorylation of STAT3, induces cell apoptosis through SHP-1 dependent STAT3 inactivation.	Int J Biol Sci, 2024, 20(6):2323-2338 Bone Joint Res, 2024, 13(4):137-148 Proc Natl Acad Sci U S A, 2021, 118(40)e2103623118
S4358	Pimozide	Pimozide (Orap, R6238) is an antagonist of Dopamine Receptors with Ki of 0.83 nM, 3.0 nM and 6600 nM for dopamine D3, D2 and D1 receptors, respectively. Pimozide also exhibits binding affinity at 5-HT1A and α1-adrenoceptor with Ki of 310 nM and 39 nM, respectively. Pimozide is an antipsychotic drug with anti-tumor activity and suppresses STAT3 and STAT5 activity.	Mol Metab, 2025, 91:102069 Cell Rep Med, 2023, 10.1016/j.xcrm.2023.101286 Biol Pharm Bull, 2021, 10.1248/bpb.b21-00531
S6898	RCM-1	RCM-1 is a nontoxic inhibitor of Forkhead box M1 (FOXM1) that suppresses goblet cell metaplasia and prevents IL-13 and STAT6 signaling in allergen-exposed mice. RCM-1 decreases carcinogenesis and nuclear β-catenin.	Parasit Vectors, 2025, 18(1):100 J Mol Histol, 2024, 55(6):1259-1270 Front Immunol, 2022, 13:863034
S0981	BD750	BD750 is an immunosuppressant and a dual inhibitor of JAK3 and STAT5 that inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation with IC50 of 1.5 μM and 1.1 μM for mouse and human T-cell proliferation, respectively.	Cell Mol Life Sci, 2024, 82(1):14 Bioengineered, 2022, 13(6):14616-14631
E1124	Narciclasine	Narciclasine (Lycoricidinol), an isocarbostyril alkaloid narciclasine, targets STAT3 via distinct mechanisms in tamoxifen-resistant breast cancer cells. Narciclasine suppresses phosphorylation, activation, dimerization, and nuclear translocation of STAT3 by directly binding with the STAT3 SH2 domain and leads STAT3 degradation. Narciclasine is a plant growth modulator. Narciclasine modulates the Rho/Rho kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity as well as inducing actin stress fiber formation in a RhoA-dependent manner.	Sci Adv, 2025, 11(9):eadq2881 Acta Biomater, 2024, S1742-7061(24)00036-9 POLYU ELECTRONIC THESES, 2023, viii, 164
S6919	Brevilin A	Brevilin A (6-O-Angeloylplenolina), a sesquiterpene lactone isolated from Centipeda minima, is a selective inhibitor of STAT3 and attenuates the JAKs activity by blocking the JAKs tyrosine kinase domain JH1. Brevilin A induces apoptosis and autophagy of colon adenocarcinoma cell CT26 via mitochondrial pathway and PI3K/AKT/mTOR inactivation.	Front Pharmacol, 2022, 13:795613
S7923	SH5-07 (SH-5-07)	SH5-07 is a robust hydroxamic acid-based STAT3 inhibitor, which induce antitumor cell effects in vitro and antitumor response in vivo against human glioma and breast cancer models.	Cell Rep, 2022, 39(12):110991 Cell Rep, 2022, 39(12):110991
S3810	Scutellarin	Scutellarin (Breviscapine, Breviscapin, Scutellarein-7-glucuronide), the major active principal flavonoids extracted from the Chinese herbal medicines Scutellaria baicalensis and Erigeron breviscapus (Vant.) Hand-Mazz, has many pharmacological effects, such as antioxidant, antitumor, antiviral, and antiinflammatory activities. Scutellarin can down-regulates the STAT3/Girdin/Akt signaling in HCC cells, and inhibits RANKL-mediated MAPK and NF-κB signaling pathway in osteoclasts.	Biomed Pharmacother, 2022, 155:113781
S3745	Balsalazide disodium	Balsalazide Disodium is the disodium salt form of balsalazide, an aminosalicylate and oral prodrug that is enzymatically cleaved in the colon to produce the anti-inflammatory agent mesalazine. Balsalazide Disodium suppress colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway.	Front Microbiol, 2020, 10:2936
F0200^New	Stat3 Mouse mAb
F0157^New	Phospho-Stat3 (Tyr705) Rabbit mAb	Phospho-Stat3 (Tyr705),p-Stat3,STAT3 (phospho Y705)
F0263^New	Stat1 Rabbit mAb
F1212	Phospho-STAT3 (Ser 727) Rabbit mAb	Phospho-Stat3 (Ser727),STAT3 (phospho S727)
F0199^New	Phospho-Stat1 (Tyr701) Rabbit mAb	Phospho-Stat1 (Tyr701),p-Stat1,STAT1 (phospho Y701)
F0555^New	Phospho-Stat6 (Tyr 641) Rabbit mAb	Phospho-Stat6 (Tyr641),STAT6 (phospho Y641)
F0412^New	STAT6 Rabbit mAb
F0713^New	Stat2 Rabbit mAb
F0512^New	Stat5 Rabbit mAb	Signal transducer and activator of transcription 5A, STAT5A, Signal transducer and activator of transcription 5B, STAT5B
F2923^New	STAT1 α Rabbit mAb
F0661^New	Stat4 (J22G17) Rabbit mAb
F2379^New	STAT4 Rabbit mAb
S4842	Balsalazide	Balsalazide (Colazal, Giazo), an aminosalicylate and oral prodrug, is enzymatically cleaved in the colon to produce the anti-inflammatory agent mesalazine. Balsalazide suppress colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway.
S0915	Morusin	Morusin (Mulberrochromene) is an inhibitor of NF-κB and STAT3. Morusin is a prenylated flavonoid isolated from Marsdenia australis with antitumor, antioxidant, and anti-bacteria properties.
S0918	Ginkgolic acid C17:1	Ginkgolic acid C17:1 (GAC 17:1) inhibits constitutive activation of STAT3 through the abrogation of upstream JAK2 and Src. Ginkgolic acid C17:1 can induce the substantial expression of PTEN and SHP-1. Ginkgolic acid C17:1 induces apoptosis of tumor cells.
S3267	Nicotiflorin (Kaempferol-3-O-rutinoside)	Nicotiflorin (Kaempferol-3-O-rutinoside), a flavonoid extracted from Carthamus tinctorius, alters the shape and structure of injured neurons, decreases the number of apoptotic cells, down-regulates expression of p-JAK2, p-STAT3, caspase-3, and Bax and decreases Bax immunoredactivity, and increases Bcl-2 protein expression and immunoreactivity.
S5554	Lanatoside C	Lanatoside C is a cardiac glycoside with antiviral and anti-tumor activity. Lanatoside C induces G2/M cell cycle arrest and induces autophagy and apoptosis via attenuating MAPK, Wnt, JAK-STAT, and PI3K/AKT/mTOR signaling pathways.
E3177	Centipeda Minima Extract	Centipeda Minima Extract is extracted from the medicinal herb Centipeda minima, has promising anticancer activities.
S8989	Xanthatin	Xanthatin is a sesquiterpene lactone isolated from Xanthium strumarium leaves, which can inhibit the nuclear factor kappa-B (NF-κB), mitogen-activated protein kinase (MAPK) and signal transducer and activator of transcription (STATs) signaling pathways.
S0949	Cucurbitacin IIb	Cucurbitacin IIb (CuIIb, Dihydrocucurbitacin F, 25-deacetyl hemslecin A) inhibits phosphorylation of STAT3, JNK and Erk1/2, enhances the phosphorylation of IκB and NF-κB, blocks nuclear translocation of NF-κB and decreases mRNA levels of IκBα and TNF-α. Cucurbitacin IIb exhibits anti-inflammatory activity and induces apoptosis. Cucurbitacin IIb is isolated from Hemsleya amabilis.
E5802^New	SD-436	SD-436 is a potent and selective PROTAC degrader of STAT3 with a DC50 of 0.5 μM. It induces complete and long-lasting tumor regression in leukemia and lymphoma xenograft models in mice.
E1990^New	KT-333	KT-333 is a first-in-class, potent, and selective heterobifunctional degrader of STAT3 that recruits the VHL E3 ligase for ubiquitin-proteasome-mediated degradation. It induces robust antitumor activity in preclinical models of ALK⁺ anaplastic large cell lymphoma (ALCL).
E3098	Fritillariae Cirrhosae Bulbus Extract	Fritillariae Cirrhosae Bulbus Extract is obtained from Fritillariae cirrhosae, mediates apoptosis through a STAT1 and STAT4-mediated co-regulatory network, which may be the key novel mechanism for its antitumor activity.
E0485	Stafia-1	Stafia-1 is the first STAT5a inhibitor that inhibits STAT5a (IC50=22.2 μM, Ki=10.9 μM) with at least 9‐fold selectivity over STAT5b and higher selectivity against other STAT family members.	Theranostics, 2024, 14(14):5698-5724
E2644	Tetramethylcurcumin	Tetramethylcurcumin (FLLL31), a small-molecule signal transducer and activator of transcription 3 (STAT3) inhibitor derived from curcumin, binds selectively to Janus kinase 2 and the STAT3 Src homology-2 domain, which serve crucial roles in STAT3 dimerization and signal transduction.
E0011	Linderalactone	Linderalactone inhibits human lung cancer growth by modulating the expression of apoptosis-related proteins (Bax and Bcl-2) with an IC50 of 15 µM in A-549 cells. Linderalactone induces G2/M cell cycle arrest and could also suppress the JAK/STAT signalling pathway. Linderalactone can be isolated from Radix linderae.
S8897^New	SD-36	"SD-36 is a potent, selective and efficacious PROTAC degrader of STAT3 protein with Kd of ~50 nM. It also effectively degrades mutated STAT3 proteins in cells and suppresses the transcriptional activity of STAT3 with IC50 of 10 nM. It also exerts anti-tumor activity. SD-36 is a potent, selective and efficacious PROTAC degrader of STAT3 protein with Kd of ~50 nM. It also effectively degrades mutated STAT3 proteins in cells and suppresses the transcriptional activity of STAT3 with IC50 of 10 nM. It also exerts anti-tumor activity.
E6446^New	SD-2301	SD-2301 is a potent and selective PROTAC-based STAT3 degrader that targets the VHL–cullin 2 complex, enhancing dendritic cell function and anti-tumor immunity. It synergizes with anti-PD-L1 therapy to robustly suppress tumor growth in vivo.
E3633	Ginger Extract	Ginger Extract is extracted from Zingiber officinale Roscoe, which has antioxidant potential and regulates STAT6 and TNF- α pathways.
E4735^New	2-NP	2-NP (2-(1,8-Naphthyridin-2-yl)phenol) is a selective enhancer of STAT1 transcription. It enhances the antiproliferative effects of IFN-γ on human breast cancer and fibrosarcoma cells.
E3634	Ginger Extract(1%)	Ginger Extract(1%) is extracted from Zingiber officinale Roscoe, which has antioxidant potential and regulates STAT6 and TNF- α pathways.
E0769	Ginsenoside Rh4	Ginsenoside Rh4 is an important active ingredient of traditional Chinese medicine ginseng, which has been shown to inhibit Wnt/β-Catenin, JAK2/STAT3, TGF-β/Smad2/3 and other signaling pathways.
S3292	(3R,8S)-Falcarindiol	Falcarindiol (FAD, (3R,8S)-Falcarindiol, FaDOH) is a natural polyacetylene compound found rich in many plants of the Umbelliferae family. Falcarindiol suppresses LPS-stimulated expression of inducible nitric oxide synthase (iNOS), tumor necrosis factor alpha (TNFα), interleukin-6 (IL-6), and interleukin-1 beta (IL-1β). Falcarindiol attenuates the LPS-induced activation of JNK, ERK, STAT1, and STAT3 signaling molecules.	Antioxidants (Basel), 2024, 13(12)1533 Front Cell Infect Microbiol, 2023, 13:1128000 Front Pharmacol, 2021, 12:656697
S1349	SC99	SC99 is an orally active, selective STAT3 inhibitor targeting JAK2-STAT3 pathway by docking into the ATP-binding pocket of JAK2, also inhibits phosphorylation of JAK2and STAT3 with no effects on the other kinases associated with STAT3 signaling.
E6051^New	niclosamide ethanolamine	Niclosamide ethanolamine (Niclosamide-olamine, BAY2353 olamine) is a mild mitochondrial uncoupler, anthelmintic agent, and highly potent inhibitor of STAT3 signaling pathway with an IC50 of 0.25 μM. It improves insulin levels, body weight, and muscle wasting, inhibits artery constriction, suppresses PI3K-mTORC1 signaling to block fibroblast proliferation, inhibits TGF-β1-induced EMT and ECM accumulation via the mTORC1-4EBP1 axis, activates noncanonical autophagy to sensitize fibroblasts to apoptosis, and confers renoprotection in diabetic and adriamycin-induced nondiabetic kidney disease models.
E0700	cucurbitacin E	Cucurbitacin E (α-Elaterin; α-Elaterine), a tetracyclic triterpene derived from the climbing stem of Cucumic melo L, is an inhibitor of JAK2 and STAT3.
E2398	STAT5-IN-2	STAT5-IN-2 inhibits the growth of acute and chronic myeloid leukemia cells and the phosphorylation and transcriptional activity of STAT5, but not STAT3, AKT, or Erk1/2 phosphorylation, with minimal effects on bone marrow stromal cells that play vital functions in the microenvironment of hematopoietic and leukemic cells.
S0445	SC-43	SC-43, a sorafenib derivative, is an agonist of Src-homology protein tyrosine phosphatase-1 (SHP-1/PTPN6) and reduces liver fibrosis. SC-43 reduces p-STAT3 and induces apoptosis with anti-tumor activity.
S8152	Cucurbitacin I	Cucurbitacin-I (Elatericin B, JSI 124, NSC 521777), a natural cell-permeable triterpenoid isolated from Cucurbitaceae, is a novel selective inhibitor of JAK2/STAT3.
S0456	inS3-54-A18	inS3-54A18 is a potent inhibitor of STAT3 with anti-cancer properties.
S9920	GYY4137	GYY4137 is a novel, water-soluble hydrogen sulfide (H2S)–releasing molecule with vasodilator and antihypertensive activity. GYY4137 shows potent anti-hepatocellular carcinoma activity through blocking the STAT3 pathway. GYY4137 also shows anti-inflammatory activity.Stock solutions should be stored under nitrogen, sealed.
S7024	Stattic	Stattic, the first nonpeptidic small molecule, potently inhibits STAT3 activation and nuclear translocation with IC50 of 5.1 μM in cell-free assays, highly selectivity over STAT1. Stattic induces apoptosis.	Mol Cancer, 2025, 24(1):122 J Clin Invest, 2025, 135(11)e181243 Acta Pharm Sin B, 2025, 15(3):1430-1446
S1155	NSC 74859 (S3I-201)	NSC 74859 (S3I-201) shows potent inhibition of STAT3 DNA-binding activity with IC50 of 86 μM in cell-free assays, and low activity towards STAT1 and STAT5.	Front Immunol, 2025, 16:1550405 Oncogenesis, 2025, 14(1):16 Commun Biol, 2025, 8(1):471
S1491	Fludarabine	Fludarabine is a STAT1 activation inhibitor which causes a specific depletion of STAT1 protein (and mRNA) but not of other STATs. Also a DNA synthesis inhibitor in vascular smooth muscle cells. Fludarabine induces apoptosis.	Cell Rep, 2025, 44(4):115559 JCI Insight, 2025, e181885 iScience, 2025, 28(3):111950
S1014	Bosutinib	Bosutinib is a novel, dual Src/Abl inhibitor with IC50 of 1.2 nM and 1 nM in cell-free assays, respectively. Bosutinib also effectively decreases the activity of PI3K/AKT/mTOR, MAPK/ERK and JAK/STAT3 signaling pathways by blocking the phosphorylation levels of p-ERK, p-S6, and p-STAT3. Bosutinib promotes autophagy.	Blood Adv, 2025, bloodadvances.2024015364 Virulence, 2025, 16(1):2489751 Elife, 2024, 12RP92324
S2796	WP1066	WP1066 is a novel inhibitor of JAK2 and STAT3 with IC50 of 2.30 μM and 2.43 μM in HEL cells; shows activity to JAK2, STAT3, STAT5, and ERK1/2 not JAK1 and JAK3. WP1066 induces apoptosis. Phase 1.	Nat Commun, 2024, 15(1):1987 Cancer Cell Int, 2024, 24(1):60 CNS Neurosci Ther, 2024, 30(9):e70017
S1396	Resveratrol	Resveratrol has a wide spectrum of targets including cyclooxygenases(i.e. COX, IC50=1.1 μM), lipooxygenases（LOX, IC50=2.7 μM）, kinases, sirtuins and other proteins. It has anti-cancer, anti-inflammatory, blood-sugar-lowering and other beneficial cardiovascular effects. Resveratrol induces mitophagy/autophagy and autophagy-dependent apoptosis.	Front Immunol, 2025, 16:1515605 Int J Mol Sci, 2025, 26(2)851 Biochem Biophys Res Commun, 2024, 723:150186
S2285	Cryptotanshinone (Tanshinone C)	Cryptotanshinone (Tanshinone C) is a STAT3 inhibitor with IC50 of 4.6 μM in a cell-free assay, strongly inhibits phosphorylation of STAT3 Tyr705, with a small effect on STAT3 Ser727, but none against STAT1 nor STAT5. Cryptotanshinone induces ROS-dependent autophagy and mitochondria-mediated apoptosis.	Bone Joint Res, 2024, 13(4):137-148 J Med Virol, 2023, 95(11):e29230 Microbiol Spectr, 2023, e0493222.
S2824	TPCA-1	TPCA-1 (GW683965) is an inhibitor of IKK-2 with IC50 of 17.9 nM in a cell-free assay, inhibits NF-κB pathway, exhibits 22-fold selectivity over IKK-1. TPCA-1 is also an inhibitor of STAT3 and enhances apoptosis.	EMBO J, 2025, 10.1038/s44318-025-00412-5 PLoS Pathog, 2025, 21(1):e1012915 Sci Adv, 2025, 11(4):eadq2395
S7337	SH-4-54	SH-4-54 is a potent STAT inhibitor with K_D of 300 nM and 464 nM for STAT3 and STAT5, respectively.	Nat Commun, 2024, 15(1):1835 Cell Signal, 2024, S0898-6568(24)00170-0 J Immunol, 2024, 213(4):419-434
S8605	C188-9	C188-9 (TTI 101) is a potent inhibitor of STAT3 that binds to STAT3 with high affinity (KD=4.7±0.4 nM). C188-9 is well tolerated in mice, shows good oral bioavailability, and is concentrated in tumors.	Exp Eye Res, 2025, 253:110280 Sci Adv, 2025, 11(4):eadq2395 J Nanobiotechnology, 2024, 22(1):362
S3030	Niclosamide	Niclosamide can inhibit DNA replication and inhibit STAT3 with IC50 of 0.7 μM in a cell-free assay. Niclosamide selectively inhibited the phosphorylation of STAT3 and had no obvious inhibition against the activation of other homologues (e.g., STAT1 and STAT5).	Pharmaceutics, 2025, 17(3)332 Cytokine, 2025, 186:156850 Int J Biol Sci, 2024, 20(7):2440-2453
S7769	BP-1-102	BP-1-102 is a potent, orally bioavailable and selective STAT3 inhibitor, binds Stat3 with an affinity Kd of 504 nM and blocks Stat3-phospho-tyrosine (pTyr) peptide interactions and Stat3 activation at 4-6.8 μM.	Cancers (Basel), 2025, 17(2)267 Theranostics, 2024, 14(3):1224-1240 Cell Rep, 2024, 43(2):113751
S7977	Napabucasin (BBI608)	Napabucasin (BBI608) is an orally available Stat3 and cancer cell stemness inhibitor.	Cancers (Basel), 2025, 17(3)477 Nat Commun, 2024, 15(1):1754 J Transl Med, 2024, 22(1):1125
S7501	HO-3867	HO-3867, an analog of curcumin, is a selective STAT3 inhibitor that inhibits its phosphorylation, transcription, and DNA binding without affecting the expression of other active STATs. HO-3867 induces apoptosis.	Int J Biol Sci, 2025, 21(5):1914-1931 Biomedicines, 2023, 11(3)694 Evid Based Complement Alternat Med, 2023, 2023:8378581
S4182	Nifuroxazide	Nifuroxazide is a cell-permeable and orally available nitrofuran-based antidiarrheal agent that effectively suppresses the activation of cellular STAT1/3/5 transcription activity with IC50 of 3 μM against IL-6-induced STAT3 activation in U3A cells.	Nat Commun, 2025, 16(1):2159 Cell Death Dis, 2024, 15(1):70 Cell Oncol (Dordr), 2024, 10.1007/s13402-024-00989-9
S8685	AS1517499	AS1517499 is a novel and potent STAT6 inhibitor with an IC50 value of 21 nM.	J Clin Invest, 2025, e169152 Arthritis Res Ther, 2025, 27(1):12 Nature, 2024, 625(7996):778-787
S9015	Homoharringtonine (HHT)	Homoharringtonine (HHT), a plant alkaloid with antitumor properties, inhibits protein translation by preventing the initial elongation step of protein synthesis via an interaction with the ribosomal A-site. Homoharringtonine reversiblely inhibits IL-6-induced STAT3 Tyrosine 705 phosphorylation and reduced anti-apoptotic proteins expression.	Nat Commun, 2025, 16(1):617 iScience, 2024, 27(10):110862 Vet Comp Oncol, 2024, 10.1111/vco.12999
S2265	Artesunate	Artesunate is a part of the artemisinin group of agents with an IC50 of < 5 μM for small cell lung carcinoma cell line H69. It is a potential inhibitor of STAT-3 and exhibits selective cytotoxicity of cancer cells over normal cells in vitro; A potent inhibitor of EXP1.	Phytomedicine, 2024, 136:156333 Virus Res, 2024, 349:199448 Int Immunopharmacol, 2023, 119:110205
S6784	STAT5-IN-1	STAT5-IN-1 is a potent and selective STAT5 inhibitor with IC50 of 47 μM for STAT5β isoform.	J Exp Clin Cancer Res, 2025, 44(1):68 Proc Natl Acad Sci U S A, 2024, 121(11):e2317658121 Cell Mol Life Sci, 2024, 81(1):152
S7951	Ochromycinone (STA-21)	Ochromycinone (STA-21) is a selective STAT3 inhibitor.	Cell Rep, 2023, 42(2):112137 Neural Regen Res, 2023, 18(6):1325-1331 Biochem Pharmacol, 2021, 192:114688
S8561	HJC0152	HJC0152 is a signal transducer and activator of transcription 3 (STAT3) inhibitor with remarkably improved aqueous solubility.	Cell Mol Immunol, 2025, 10.1038/s41423-025-01301-x Cancer Discov, 2023, 13(7):1616-1635 Cancer Commun (Lond), 2023, 43(5):562-581
S8197	APTSTAT3-9R	APTSTAT3-9R is a specific STAT3-binding peptide with addition of a cell-penetrating motif. The treatment of APTSTAT3-9R in various types of cancer cells blocks STAT3 phosphorylation and reduces expression of STAT targets.	Hepatology, 2024, 10.1097/HEP.0000000000001003 Biophys Rep (N Y), 2023, 3(2):100108 Sci Rep, 2022, 12(1):7
S0818	STAT3-IN-1	STAT3-IN-1 (compound 7d) is an excellent, selective and orally active inhibitor of STAT3 with IC50 of 1.82 μM and 2.14 μM in HT29 and MDA-MB 231 cells, respectively. STAT3-IN-1 induces apoptosis of tumor cells.	J Exp Clin Cancer Res, 2025, 44(1):68 Front Immunol, 2024, 15:1470907 JCI Insight, 2023, 8(22)e164672
S0986	SC-1	SC-1 (1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea, STAT3-IN-7), a Sorafenib analogue and potently inhibits the phosphorylation of STAT3, induces cell apoptosis through SHP-1 dependent STAT3 inactivation.	Int J Biol Sci, 2024, 20(6):2323-2338 Bone Joint Res, 2024, 13(4):137-148 Proc Natl Acad Sci U S A, 2021, 118(40)e2103623118
S4358	Pimozide	Pimozide (Orap, R6238) is an antagonist of Dopamine Receptors with Ki of 0.83 nM, 3.0 nM and 6600 nM for dopamine D3, D2 and D1 receptors, respectively. Pimozide also exhibits binding affinity at 5-HT1A and α1-adrenoceptor with Ki of 310 nM and 39 nM, respectively. Pimozide is an antipsychotic drug with anti-tumor activity and suppresses STAT3 and STAT5 activity.	Mol Metab, 2025, 91:102069 Cell Rep Med, 2023, 10.1016/j.xcrm.2023.101286 Biol Pharm Bull, 2021, 10.1248/bpb.b21-00531
S6898	RCM-1	RCM-1 is a nontoxic inhibitor of Forkhead box M1 (FOXM1) that suppresses goblet cell metaplasia and prevents IL-13 and STAT6 signaling in allergen-exposed mice. RCM-1 decreases carcinogenesis and nuclear β-catenin.	Parasit Vectors, 2025, 18(1):100 J Mol Histol, 2024, 55(6):1259-1270 Front Immunol, 2022, 13:863034
S0981	BD750	BD750 is an immunosuppressant and a dual inhibitor of JAK3 and STAT5 that inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation with IC50 of 1.5 μM and 1.1 μM for mouse and human T-cell proliferation, respectively.	Cell Mol Life Sci, 2024, 82(1):14 Bioengineered, 2022, 13(6):14616-14631
E1124	Narciclasine	Narciclasine (Lycoricidinol), an isocarbostyril alkaloid narciclasine, targets STAT3 via distinct mechanisms in tamoxifen-resistant breast cancer cells. Narciclasine suppresses phosphorylation, activation, dimerization, and nuclear translocation of STAT3 by directly binding with the STAT3 SH2 domain and leads STAT3 degradation. Narciclasine is a plant growth modulator. Narciclasine modulates the Rho/Rho kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity as well as inducing actin stress fiber formation in a RhoA-dependent manner.	Sci Adv, 2025, 11(9):eadq2881 Acta Biomater, 2024, S1742-7061(24)00036-9 POLYU ELECTRONIC THESES, 2023, viii, 164
S6919	Brevilin A	Brevilin A (6-O-Angeloylplenolina), a sesquiterpene lactone isolated from Centipeda minima, is a selective inhibitor of STAT3 and attenuates the JAKs activity by blocking the JAKs tyrosine kinase domain JH1. Brevilin A induces apoptosis and autophagy of colon adenocarcinoma cell CT26 via mitochondrial pathway and PI3K/AKT/mTOR inactivation.	Front Pharmacol, 2022, 13:795613
S7923	SH5-07 (SH-5-07)	SH5-07 is a robust hydroxamic acid-based STAT3 inhibitor, which induce antitumor cell effects in vitro and antitumor response in vivo against human glioma and breast cancer models.	Cell Rep, 2022, 39(12):110991 Cell Rep, 2022, 39(12):110991
S3810	Scutellarin	Scutellarin (Breviscapine, Breviscapin, Scutellarein-7-glucuronide), the major active principal flavonoids extracted from the Chinese herbal medicines Scutellaria baicalensis and Erigeron breviscapus (Vant.) Hand-Mazz, has many pharmacological effects, such as antioxidant, antitumor, antiviral, and antiinflammatory activities. Scutellarin can down-regulates the STAT3/Girdin/Akt signaling in HCC cells, and inhibits RANKL-mediated MAPK and NF-κB signaling pathway in osteoclasts.	Biomed Pharmacother, 2022, 155:113781
S0915	Morusin	Morusin (Mulberrochromene) is an inhibitor of NF-κB and STAT3. Morusin is a prenylated flavonoid isolated from Marsdenia australis with antitumor, antioxidant, and anti-bacteria properties.
S0918	Ginkgolic acid C17:1	Ginkgolic acid C17:1 (GAC 17:1) inhibits constitutive activation of STAT3 through the abrogation of upstream JAK2 and Src. Ginkgolic acid C17:1 can induce the substantial expression of PTEN and SHP-1. Ginkgolic acid C17:1 induces apoptosis of tumor cells.
S3267	Nicotiflorin (Kaempferol-3-O-rutinoside)	Nicotiflorin (Kaempferol-3-O-rutinoside), a flavonoid extracted from Carthamus tinctorius, alters the shape and structure of injured neurons, decreases the number of apoptotic cells, down-regulates expression of p-JAK2, p-STAT3, caspase-3, and Bax and decreases Bax immunoredactivity, and increases Bcl-2 protein expression and immunoreactivity.
S5554	Lanatoside C	Lanatoside C is a cardiac glycoside with antiviral and anti-tumor activity. Lanatoside C induces G2/M cell cycle arrest and induces autophagy and apoptosis via attenuating MAPK, Wnt, JAK-STAT, and PI3K/AKT/mTOR signaling pathways.
E3177	Centipeda Minima Extract	Centipeda Minima Extract is extracted from the medicinal herb Centipeda minima, has promising anticancer activities.
S8989	Xanthatin	Xanthatin is a sesquiterpene lactone isolated from Xanthium strumarium leaves, which can inhibit the nuclear factor kappa-B (NF-κB), mitogen-activated protein kinase (MAPK) and signal transducer and activator of transcription (STATs) signaling pathways.
S0949	Cucurbitacin IIb	Cucurbitacin IIb (CuIIb, Dihydrocucurbitacin F, 25-deacetyl hemslecin A) inhibits phosphorylation of STAT3, JNK and Erk1/2, enhances the phosphorylation of IκB and NF-κB, blocks nuclear translocation of NF-κB and decreases mRNA levels of IκBα and TNF-α. Cucurbitacin IIb exhibits anti-inflammatory activity and induces apoptosis. Cucurbitacin IIb is isolated from Hemsleya amabilis.
E5802^New	SD-436	SD-436 is a potent and selective PROTAC degrader of STAT3 with a DC50 of 0.5 μM. It induces complete and long-lasting tumor regression in leukemia and lymphoma xenograft models in mice.
E1990^New	KT-333	KT-333 is a first-in-class, potent, and selective heterobifunctional degrader of STAT3 that recruits the VHL E3 ligase for ubiquitin-proteasome-mediated degradation. It induces robust antitumor activity in preclinical models of ALK⁺ anaplastic large cell lymphoma (ALCL).
E0485	Stafia-1	Stafia-1 is the first STAT5a inhibitor that inhibits STAT5a (IC50=22.2 μM, Ki=10.9 μM) with at least 9‐fold selectivity over STAT5b and higher selectivity against other STAT family members.	Theranostics, 2024, 14(14):5698-5724
E2644	Tetramethylcurcumin	Tetramethylcurcumin (FLLL31), a small-molecule signal transducer and activator of transcription 3 (STAT3) inhibitor derived from curcumin, binds selectively to Janus kinase 2 and the STAT3 Src homology-2 domain, which serve crucial roles in STAT3 dimerization and signal transduction.
E0011	Linderalactone	Linderalactone inhibits human lung cancer growth by modulating the expression of apoptosis-related proteins (Bax and Bcl-2) with an IC50 of 15 µM in A-549 cells. Linderalactone induces G2/M cell cycle arrest and could also suppress the JAK/STAT signalling pathway. Linderalactone can be isolated from Radix linderae.
E0769	Ginsenoside Rh4	Ginsenoside Rh4 is an important active ingredient of traditional Chinese medicine ginseng, which has been shown to inhibit Wnt/β-Catenin, JAK2/STAT3, TGF-β/Smad2/3 and other signaling pathways.
S3292	(3R,8S)-Falcarindiol	Falcarindiol (FAD, (3R,8S)-Falcarindiol, FaDOH) is a natural polyacetylene compound found rich in many plants of the Umbelliferae family. Falcarindiol suppresses LPS-stimulated expression of inducible nitric oxide synthase (iNOS), tumor necrosis factor alpha (TNFα), interleukin-6 (IL-6), and interleukin-1 beta (IL-1β). Falcarindiol attenuates the LPS-induced activation of JNK, ERK, STAT1, and STAT3 signaling molecules.	Antioxidants (Basel), 2024, 13(12)1533 Front Cell Infect Microbiol, 2023, 13:1128000 Front Pharmacol, 2021, 12:656697
S1349	SC99	SC99 is an orally active, selective STAT3 inhibitor targeting JAK2-STAT3 pathway by docking into the ATP-binding pocket of JAK2, also inhibits phosphorylation of JAK2and STAT3 with no effects on the other kinases associated with STAT3 signaling.
E6051^New	niclosamide ethanolamine	Niclosamide ethanolamine (Niclosamide-olamine, BAY2353 olamine) is a mild mitochondrial uncoupler, anthelmintic agent, and highly potent inhibitor of STAT3 signaling pathway with an IC50 of 0.25 μM. It improves insulin levels, body weight, and muscle wasting, inhibits artery constriction, suppresses PI3K-mTORC1 signaling to block fibroblast proliferation, inhibits TGF-β1-induced EMT and ECM accumulation via the mTORC1-4EBP1 axis, activates noncanonical autophagy to sensitize fibroblasts to apoptosis, and confers renoprotection in diabetic and adriamycin-induced nondiabetic kidney disease models.
E0700	cucurbitacin E	Cucurbitacin E (α-Elaterin; α-Elaterine), a tetracyclic triterpene derived from the climbing stem of Cucumic melo L, is an inhibitor of JAK2 and STAT3.
E2398	STAT5-IN-2	STAT5-IN-2 inhibits the growth of acute and chronic myeloid leukemia cells and the phosphorylation and transcriptional activity of STAT5, but not STAT3, AKT, or Erk1/2 phosphorylation, with minimal effects on bone marrow stromal cells that play vital functions in the microenvironment of hematopoietic and leukemic cells.
S0445	SC-43	SC-43, a sorafenib derivative, is an agonist of Src-homology protein tyrosine phosphatase-1 (SHP-1/PTPN6) and reduces liver fibrosis. SC-43 reduces p-STAT3 and induces apoptosis with anti-tumor activity.
S8152	Cucurbitacin I	Cucurbitacin-I (Elatericin B, JSI 124, NSC 521777), a natural cell-permeable triterpenoid isolated from Cucurbitaceae, is a novel selective inhibitor of JAK2/STAT3.
S0456	inS3-54-A18	inS3-54A18 is a potent inhibitor of STAT3 with anti-cancer properties.
S9920	GYY4137	GYY4137 is a novel, water-soluble hydrogen sulfide (H2S)–releasing molecule with vasodilator and antihypertensive activity. GYY4137 shows potent anti-hepatocellular carcinoma activity through blocking the STAT3 pathway. GYY4137 also shows anti-inflammatory activity.Stock solutions should be stored under nitrogen, sealed.
S9664	Colivelin	Colivelin (CLN) is a brain-penetrant neuroprotective peptide with potent long-term capacity against Aβ deposition, neuronal apoptosis, and synaptic plasticity deficits in neurodegenerative disease. Colivelin is an activator of STAT3.	J Clin Invest, 2025, 135(11)e181243 Stem Cell Res Ther, 2025, 16(1):40 Int J Mol Med, 2025, 55(3)42
S3745	Balsalazide disodium	Balsalazide Disodium is the disodium salt form of balsalazide, an aminosalicylate and oral prodrug that is enzymatically cleaved in the colon to produce the anti-inflammatory agent mesalazine. Balsalazide Disodium suppress colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway.	Front Microbiol, 2020, 10:2936
S4842	Balsalazide	Balsalazide (Colazal, Giazo), an aminosalicylate and oral prodrug, is enzymatically cleaved in the colon to produce the anti-inflammatory agent mesalazine. Balsalazide suppress colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway.
E3633	Ginger Extract	Ginger Extract is extracted from Zingiber officinale Roscoe, which has antioxidant potential and regulates STAT6 and TNF- α pathways.
E4735^New	2-NP	2-NP (2-(1,8-Naphthyridin-2-yl)phenol) is a selective enhancer of STAT1 transcription. It enhances the antiproliferative effects of IFN-γ on human breast cancer and fibrosarcoma cells.
E3634	Ginger Extract(1%)	Ginger Extract(1%) is extracted from Zingiber officinale Roscoe, which has antioxidant potential and regulates STAT6 and TNF- α pathways.
F0200^New	Stat3 Mouse mAb
F0157^New	Phospho-Stat3 (Tyr705) Rabbit mAb	Phospho-Stat3 (Tyr705),p-Stat3,STAT3 (phospho Y705)
F0263^New	Stat1 Rabbit mAb
F0199^New	Phospho-Stat1 (Tyr701) Rabbit mAb	Phospho-Stat1 (Tyr701),p-Stat1,STAT1 (phospho Y701)
F0555^New	Phospho-Stat6 (Tyr 641) Rabbit mAb	Phospho-Stat6 (Tyr641),STAT6 (phospho Y641)
F0412^New	STAT6 Rabbit mAb
F0713^New	Stat2 Rabbit mAb
F0512^New	Stat5 Rabbit mAb	Signal transducer and activator of transcription 5A, STAT5A, Signal transducer and activator of transcription 5B, STAT5B
F2923^New	STAT1 α Rabbit mAb
F0661^New	Stat4 (J22G17) Rabbit mAb
F2379^New	STAT4 Rabbit mAb
E5802^New	SD-436	SD-436 is a potent and selective PROTAC degrader of STAT3 with a DC50 of 0.5 μM. It induces complete and long-lasting tumor regression in leukemia and lymphoma xenograft models in mice.
E1990^New	KT-333	KT-333 is a first-in-class, potent, and selective heterobifunctional degrader of STAT3 that recruits the VHL E3 ligase for ubiquitin-proteasome-mediated degradation. It induces robust antitumor activity in preclinical models of ALK⁺ anaplastic large cell lymphoma (ALCL).
S8897^New	SD-36	"SD-36 is a potent, selective and efficacious PROTAC degrader of STAT3 protein with Kd of ~50 nM. It also effectively degrades mutated STAT3 proteins in cells and suppresses the transcriptional activity of STAT3 with IC50 of 10 nM. It also exerts anti-tumor activity. SD-36 is a potent, selective and efficacious PROTAC degrader of STAT3 protein with Kd of ~50 nM. It also effectively degrades mutated STAT3 proteins in cells and suppresses the transcriptional activity of STAT3 with IC50 of 10 nM. It also exerts anti-tumor activity.
E6446^New	SD-2301	SD-2301 is a potent and selective PROTAC-based STAT3 degrader that targets the VHL–cullin 2 complex, enhancing dendritic cell function and anti-tumor immunity. It synergizes with anti-PD-L1 therapy to robustly suppress tumor growth in vivo.
E4735^New	2-NP	2-NP (2-(1,8-Naphthyridin-2-yl)phenol) is a selective enhancer of STAT1 transcription. It enhances the antiproliferative effects of IFN-γ on human breast cancer and fibrosarcoma cells.
E6051^New	niclosamide ethanolamine	Niclosamide ethanolamine (Niclosamide-olamine, BAY2353 olamine) is a mild mitochondrial uncoupler, anthelmintic agent, and highly potent inhibitor of STAT3 signaling pathway with an IC50 of 0.25 μM. It improves insulin levels, body weight, and muscle wasting, inhibits artery constriction, suppresses PI3K-mTORC1 signaling to block fibroblast proliferation, inhibits TGF-β1-induced EMT and ECM accumulation via the mTORC1-4EBP1 axis, activates noncanonical autophagy to sensitize fibroblasts to apoptosis, and confers renoprotection in diabetic and adriamycin-induced nondiabetic kidney disease models.

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