Pyroptosis

Choose Selective Pyroptosis Inhibitors

Pyroptosis Products

All (4)
Pyroptosis Inhibitors (3)
Pyroptosis Activator (1)
New Pyroptosis Products

Catalog No.	Product Name	Information	Product Use Citations
S1680	Disulfiram (NSC 190940)	Disulfiram (NSC 190940, Tetraethylthiuram disulfide, TETD) is a specific inhibitor of aldehyde-dehydrogenase (ALDH) with IC50 of 0.15 μM and 1.45 μM for hALDH1 and hALDH2, respectively. Disulfiram is used for the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. Disulfiram induces apoptosis. Disulfiram is also an inhibitor of pore formation by gasdermin D (GSDMD).	Free Radic Biol Med, 2022, 181:14-28 mBio, 2022, 10.1128/mbio.02739-21 J Leukoc Biol, 2022, 10.1002/JLB.5MA1121-644R
S5465	Morroniside	Morroniside, an iridoid glycoside, is the main active ingredient from Cornus officinalis Sieb. et Zucc. and Sambucus williamsii Hance. It has therapeutic effects on diabetic angiopathies, renal damage, lipid metabolism and inflammation and bone resorption. Morroniside has neuroprotective effect by inhibiting neuron apoptosis and MMP2/9 expression.
S9817	Ac-FLTD-CMK	Ac-FLTD-CMK is a specific inhibitor for inflammatory caspases. Ac-FLTD-CMK inhibits gasdermin D (GSDMD) cleavage by caspases-1, -4, -5, and -11 in vitro. Ac-FLTD-CMK is effective against caspases-1, caspases-4 and caspases-5 with IC50 of 46.7 nM, 1.49 μM and 329 nM, respectively.
S9302	Polyphyllin VI	Polyphyllin VI derived from Paris polyphylla possess anti-cancer activities.
S1680	Disulfiram (NSC 190940)	Disulfiram (NSC 190940, Tetraethylthiuram disulfide, TETD) is a specific inhibitor of aldehyde-dehydrogenase (ALDH) with IC50 of 0.15 μM and 1.45 μM for hALDH1 and hALDH2, respectively. Disulfiram is used for the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. Disulfiram induces apoptosis. Disulfiram is also an inhibitor of pore formation by gasdermin D (GSDMD).	Free Radic Biol Med, 2022, 181:14-28 mBio, 2022, 10.1128/mbio.02739-21 J Leukoc Biol, 2022, 10.1002/JLB.5MA1121-644R
S5465	Morroniside	Morroniside, an iridoid glycoside, is the main active ingredient from Cornus officinalis Sieb. et Zucc. and Sambucus williamsii Hance. It has therapeutic effects on diabetic angiopathies, renal damage, lipid metabolism and inflammation and bone resorption. Morroniside has neuroprotective effect by inhibiting neuron apoptosis and MMP2/9 expression.
S9817	Ac-FLTD-CMK	Ac-FLTD-CMK is a specific inhibitor for inflammatory caspases. Ac-FLTD-CMK inhibits gasdermin D (GSDMD) cleavage by caspases-1, -4, -5, and -11 in vitro. Ac-FLTD-CMK is effective against caspases-1, caspases-4 and caspases-5 with IC50 of 46.7 nM, 1.49 μM and 329 nM, respectively.
S9302	Polyphyllin VI	Polyphyllin VI derived from Paris polyphylla possess anti-cancer activities.