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p53

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p53 Signaling Pathway Map

p53 Products

All (30)
p53 Inhibitors (7)
p53 Antibodie (1)
p53 Activators (18)
p53 Modulators (2)
New p53 Products

Catalog No.	Product Name	Information	Product Use Citations
S2929	Pifithrin-α (PFTα) HBr	Pifithrin-α is an inhibitor of p53, inhibiting p53-dependent transactivation of p53-responsive genes. Pifithrin-α is also a potent agonist of the aryl hydrocarbon receptor (AhR).	J Exp Clin Cancer Res, 2022, 41(1):130 Cell Mol Gastroenterol Hepatol, 2022, S2352-345X(22)00063-7 PLoS Pathog, 2022, 18(3):e1010365
S2930	Pifithrin-μ	Pifithrin-μ (NSC 303580, PFTμ, 2-Phenylethynesulfonamide) is a specific p53 inhibitor by reducing its affinity to Bcl-xL and Bcl-2, and also inhibits HSP70 function and autophagy.	Chin Med J (Engl), 2022, 135(5):606-618 Shock, 2021, 55(1):74-82 Radiat Res, 2020, 193(2):119-129
S5791	Cyclic Pifithrin-α hydrobromide	Cyclic Pifithrin-α hydrobromide is the hydrobromide salt form of Cyclic Pifithrin-α, which is a transcriptional inhibitor of p53.	Clin Transl Med, 2020, 10.1002/ctm2.41
S7030	RG-7112	RG7112 (RO5045337) is an orally bioavailable and selective p53-MDM2 inhibitor with HTRF IC50 of 18 nM.	Phytomedicine, 2022, 98:153963 Hum Cell, 2022, 10.1007/s13577-022-00671-y Nat Commun, 2021, 12(1):4019
S8059	Nutlin-3a	Nutlin-3a ((-)-Nutlin-3), the active enantiomer of Nutlin-3, inhibits the p53/MDM2 interaction with IC50 of 90 nM in a cell-free assay. Nutlin-3a induces autophagy and apoptosis in a p53-dependent manner.	Adv Sci (Weinh), 2022, e2200742 Nat Chem Biol, 2022, 10.1038/s41589-022-00996-7 Redox Biol, 2022, 50:102240
S8187	ReACp53	ReACp53 is a cell-penetrating peptide, designed to inhibit p53 amyloid formation, resues p53 function in cancer cell lines and in organoids derived from high-grade serous ovarian carcinomas (HGSOC).
S9235	Didymin	Didymin (Neoponcirin, Isosakuranetin-7-O-rutinoside) is a citrus-derived natural compound that kills p53 wild-type as well as drug-resistant p53-mutant neuroblastoma cells in culture. It possesses antioxidant, anti-inflammation and anti-cancer properties.
A5182	p63 Rabbit Recombinant mAb	p63 Rabbit Recombinant mAb detects endogenous level of total p63.
S0507	CBL0137	CBL0137 (Curaxin-137) is an inhibitor of the histone chaperone FACT (facilitates chromatin transcription) that simultaneously suppresses NF-κB and activates p53 with EC50 of 0.47 μM and 0.37 μM, respectively.	Cancer Lett, 2021, 520:201-212 Cancer Lett, 2021, 499:232-242 PLoS One, 2021, 16(6):e0252504
S1172	Serdemetan (JNJ-26854165)	Serdemetan (JNJ-26854165) acts as a HDM2 ubiquitin ligase antagonist and also induces early apoptosis in p53 wild-type cells, inhibits cellular proliferation followed by delayed apoptosis in the absence of functional p53. Phase 1.	Signal Transduct Target Ther, 2022, 7(1):97 iScience, 2021, 24(9):103080 Cancer Res, 2020, canres.3499.2019
S2176	Tenovin-3	Tenovin-3 is an inhibitor of SIRT2. Tenovin-3 is able to increase p53 levels in MCF-7 cells.
S2341	(-)-Parthenolide	(-)-Parthenolide, an inhibitor of the Nuclear Factor-κB Pathway, specifically depletes HDAC1 protein without affecting other class I/II HDACs; Also promotes the ubiquitination of MDM2 and activates p53 cellular functions.	PLoS Genet, 2021, 17(11):e1009890 Theranostics, 2020, 10(22):9923-9936 J Biol Chem, 2020, 295(11):3576-3589
S2427	Triglycidyl Isocyanurate (Teroxirone)	Triglycidyl Isocyanurate (Teroxirone, Tris(2,3-epoxypropyl) Isocyanurate, TGI, TGIC) is a triazene triepoxide with antineoplastic activity. It inhibits growth of human non-small cell lung cancer cells by activating p53. Triglycidyl Isocyanurate alkylates and cross-links DNA, thereby inhibiting DNA replication. Triglycidyl Isocyanurate is also used in various polyester powder coatings in the metal finishing industry.
S2678	NSC 207895	NSC 207895 (XI-006) suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and also regulates MDM2, an E3 ligase.	Genes Dev, 2020, 34(7-8):526-543 Oncotarget, 2020, 11(46):4224-4242 Sci Rep, 2019, 9(1):1897
S2781	RITA (NSC 652287)	RITA (NSC 652287) induces both DNA-protein and DNA-DNA cross-links with no detectable DNA single-strand breaks, and also inhibits MDM2-p53 interaction by targeting p53.	Cancer Cell, 2020, S1535-6108(20)30605-X Cancers (Basel), 2020, 12(9)E2668 Cancer Discov, 2020, CD-20-0160
S4900	Tenovin-6	Tenovin-6 is a small molecule activator of p53 transcriptional activity and inhibits dihydroorotate dehydrogenase (DHODH). Tenovin-6 is also an inhibitor of SirT1 and SirT2.	Front Immunol, 2021, 12:685523 Biomed Pharmacother, 2020, 125:109948 J Cell Sci, 2019, 132(6)
S5811	Kevetrin hydrochloride	Kevetrin hydrochloride (Thioureidobutyronitrile) is a water-soluble, small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity.
S7149	NSC 319726	NSC319726 is a p53(R175) mutant reactivator, exhibits growth inhibition in cells expressing mutant p53, with IC50 of 8 nM for p53(R175) mutant, shows no inhibition for p53 wild-type cells.	Microbiol Spectr, 2021, 9(3):e0139521 Cell, 2020, 182(3):685-712.e19 Cell, 2020, 182(3):685-712.e19
S7649	MI-773 (SAR405838)	MI-773 (SAR405838) is an orally available MDM2 antagonist with K_i of 0.88 nM. Phase 1.	Cell Rep, 2021, 36(5):109482 NPJ Precis Oncol, 2021, 5(1):96 Cancers (Basel), 2020, 12(8):E2157
S7723	PRIMA-1	PRIMA-1 (2,2-Bis(hydroxymethyl)-3-quinuclidinone) is a mutant p53 reactivator. It induces apoptosis and inhibits growth of human tumors with mutant p53.	Nat Chem Biol, 2022, 10.1038/s41589-022-00996-7 Hum Cell, 2022, 10.1007/s13577-022-00671-y Hum Cell, 2021, 10.1007/s13577-021-00639-4
S7724	Eprenetapopt (APR-246)	Eprenetapopt (APR-246, PRIMA-1MET) is a small organic molecule that has been shown to restore tumour-suppressor function primarily to mutant p53 and also to induce cell death in various cancer types. APR-246 induces apoptosis and autophagy.	Cells, 2022, 11(5)794 Hum Cell, 2022, 10.1007/s13577-022-00671-y Haematologica, 2021, 10.3324/haematol.2020.259531
S8000	Tenovin-1	Tenovin-1 protects against MDM2-mediated p53 degradation, which involves ubiquitination, and acts through inhibition of protein-deacetylating activities of SirT1 and SirT2. Tenovin-1 is also an inhibitor of dihydroorotate dehydrogenase (DHODH).	J Pharm Biomed Anal, 2021, 201:114121 J Transl Med, 2019, 17(1):76 Sci Rep, 2019, 9(1):1897
S8106	NSC59984	NSC59984 is a p53 pathway activator via induction of mutant p53 protein degradation and p73 activation.	Front Bioeng Biotechnol, 2020, 8:538663 Micromachines (Basel), 2020, 11(2)
S8149	NSC348884	NSC348884, as a nucleophosmin inhibitor, inhibit cell proliferation and induce apoptosis in various cancer cell lines with IC50 values ranging from 1.4-4 µM.	Nat Commun, 2020, 3;11(1):1669 Virulence, 2020, 11(1):1379-1393 Reproduction, 2020, 160(4):491-500
S8483	CBL0137 HCl	CBL0137 (CBLC137, Curaxin 137) HCl activates p53 and inhibits NF-kB with EC50s of 0.37 μM and 0.47 μM in the cell-based p53 and NF-kB reporter assays, respectively. It also inhibits histone chaperone FACT (facilitates chromatin transcription complex).	Cancer Lett, 2021, 520:201-212 Cancer Lett, 2021, 499:232-242 bioRxiv, 2021, 10.1101/2021.04.20.440573
S8580	COTI-2	COTI-2 is an orally available third generation thiosemicarbazone and activator of mutant forms of the p53 protein, with potential antineoplastic activity.	DASH, 2020, None
S6851	RA-190	RA190, a bis-benzylidine piperidon, is a potent, selective and oral effective inhibitor of proteasome ubiquitin receptor RPN13/ADRM1 with anticancer activity. RA190 triggers ER stress response, p53/p21 signaling axis and autophagy in multiple myeloma cells.
S6882	HI-TOPK-032	HI-TOPK-032 is a potent and specific inhibitor of TOPK. HI-TOPK-032 also reduces ERK-RSK phosphorylation, regulates of the abundance of p53, cleaved caspase-7, and cleaved PARP, and induces apoptosis in cancer cells.
E0035^New	CP-31398 Dihydrochloride	CP-31398 Dihydrochloride stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-type p53.
S8728	PK11000	PK11000 stabilizes the DBD of both WT and mutant p53 proteins by covalent cysteine modification without compromising DNA binding and effective in inducing cell death.
S2929	Pifithrin-α (PFTα) HBr	Pifithrin-α is an inhibitor of p53, inhibiting p53-dependent transactivation of p53-responsive genes. Pifithrin-α is also a potent agonist of the aryl hydrocarbon receptor (AhR).	J Exp Clin Cancer Res, 2022, 41(1):130 Cell Mol Gastroenterol Hepatol, 2022, S2352-345X(22)00063-7 PLoS Pathog, 2022, 18(3):e1010365
S2930	Pifithrin-μ	Pifithrin-μ (NSC 303580, PFTμ, 2-Phenylethynesulfonamide) is a specific p53 inhibitor by reducing its affinity to Bcl-xL and Bcl-2, and also inhibits HSP70 function and autophagy.	Chin Med J (Engl), 2022, 135(5):606-618 Shock, 2021, 55(1):74-82 Radiat Res, 2020, 193(2):119-129
S5791	Cyclic Pifithrin-α hydrobromide	Cyclic Pifithrin-α hydrobromide is the hydrobromide salt form of Cyclic Pifithrin-α, which is a transcriptional inhibitor of p53.	Clin Transl Med, 2020, 10.1002/ctm2.41
S7030	RG-7112	RG7112 (RO5045337) is an orally bioavailable and selective p53-MDM2 inhibitor with HTRF IC50 of 18 nM.	Phytomedicine, 2022, 98:153963 Hum Cell, 2022, 10.1007/s13577-022-00671-y Nat Commun, 2021, 12(1):4019
S8059	Nutlin-3a	Nutlin-3a ((-)-Nutlin-3), the active enantiomer of Nutlin-3, inhibits the p53/MDM2 interaction with IC50 of 90 nM in a cell-free assay. Nutlin-3a induces autophagy and apoptosis in a p53-dependent manner.	Adv Sci (Weinh), 2022, e2200742 Nat Chem Biol, 2022, 10.1038/s41589-022-00996-7 Redox Biol, 2022, 50:102240
S8187	ReACp53	ReACp53 is a cell-penetrating peptide, designed to inhibit p53 amyloid formation, resues p53 function in cancer cell lines and in organoids derived from high-grade serous ovarian carcinomas (HGSOC).
S9235	Didymin	Didymin (Neoponcirin, Isosakuranetin-7-O-rutinoside) is a citrus-derived natural compound that kills p53 wild-type as well as drug-resistant p53-mutant neuroblastoma cells in culture. It possesses antioxidant, anti-inflammation and anti-cancer properties.
A5182	p63 Rabbit Recombinant mAb	p63 Rabbit Recombinant mAb detects endogenous level of total p63.
S0507	CBL0137	CBL0137 (Curaxin-137) is an inhibitor of the histone chaperone FACT (facilitates chromatin transcription) that simultaneously suppresses NF-κB and activates p53 with EC50 of 0.47 μM and 0.37 μM, respectively.	Cancer Lett, 2021, 520:201-212 Cancer Lett, 2021, 499:232-242 PLoS One, 2021, 16(6):e0252504
S1172	Serdemetan (JNJ-26854165)	Serdemetan (JNJ-26854165) acts as a HDM2 ubiquitin ligase antagonist and also induces early apoptosis in p53 wild-type cells, inhibits cellular proliferation followed by delayed apoptosis in the absence of functional p53. Phase 1.	Signal Transduct Target Ther, 2022, 7(1):97 iScience, 2021, 24(9):103080 Cancer Res, 2020, canres.3499.2019
S2176	Tenovin-3	Tenovin-3 is an inhibitor of SIRT2. Tenovin-3 is able to increase p53 levels in MCF-7 cells.
S2341	(-)-Parthenolide	(-)-Parthenolide, an inhibitor of the Nuclear Factor-κB Pathway, specifically depletes HDAC1 protein without affecting other class I/II HDACs; Also promotes the ubiquitination of MDM2 and activates p53 cellular functions.	PLoS Genet, 2021, 17(11):e1009890 Theranostics, 2020, 10(22):9923-9936 J Biol Chem, 2020, 295(11):3576-3589
S2427	Triglycidyl Isocyanurate (Teroxirone)	Triglycidyl Isocyanurate (Teroxirone, Tris(2,3-epoxypropyl) Isocyanurate, TGI, TGIC) is a triazene triepoxide with antineoplastic activity. It inhibits growth of human non-small cell lung cancer cells by activating p53. Triglycidyl Isocyanurate alkylates and cross-links DNA, thereby inhibiting DNA replication. Triglycidyl Isocyanurate is also used in various polyester powder coatings in the metal finishing industry.
S2678	NSC 207895	NSC 207895 (XI-006) suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and also regulates MDM2, an E3 ligase.	Genes Dev, 2020, 34(7-8):526-543 Oncotarget, 2020, 11(46):4224-4242 Sci Rep, 2019, 9(1):1897
S2781	RITA (NSC 652287)	RITA (NSC 652287) induces both DNA-protein and DNA-DNA cross-links with no detectable DNA single-strand breaks, and also inhibits MDM2-p53 interaction by targeting p53.	Cancer Cell, 2020, S1535-6108(20)30605-X Cancers (Basel), 2020, 12(9)E2668 Cancer Discov, 2020, CD-20-0160
S4900	Tenovin-6	Tenovin-6 is a small molecule activator of p53 transcriptional activity and inhibits dihydroorotate dehydrogenase (DHODH). Tenovin-6 is also an inhibitor of SirT1 and SirT2.	Front Immunol, 2021, 12:685523 Biomed Pharmacother, 2020, 125:109948 J Cell Sci, 2019, 132(6)
S5811	Kevetrin hydrochloride	Kevetrin hydrochloride (Thioureidobutyronitrile) is a water-soluble, small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity.
S7149	NSC 319726	NSC319726 is a p53(R175) mutant reactivator, exhibits growth inhibition in cells expressing mutant p53, with IC50 of 8 nM for p53(R175) mutant, shows no inhibition for p53 wild-type cells.	Microbiol Spectr, 2021, 9(3):e0139521 Cell, 2020, 182(3):685-712.e19 Cell, 2020, 182(3):685-712.e19
S7649	MI-773 (SAR405838)	MI-773 (SAR405838) is an orally available MDM2 antagonist with K_i of 0.88 nM. Phase 1.	Cell Rep, 2021, 36(5):109482 NPJ Precis Oncol, 2021, 5(1):96 Cancers (Basel), 2020, 12(8):E2157
S7723	PRIMA-1	PRIMA-1 (2,2-Bis(hydroxymethyl)-3-quinuclidinone) is a mutant p53 reactivator. It induces apoptosis and inhibits growth of human tumors with mutant p53.	Nat Chem Biol, 2022, 10.1038/s41589-022-00996-7 Hum Cell, 2022, 10.1007/s13577-022-00671-y Hum Cell, 2021, 10.1007/s13577-021-00639-4
S7724	Eprenetapopt (APR-246)	Eprenetapopt (APR-246, PRIMA-1MET) is a small organic molecule that has been shown to restore tumour-suppressor function primarily to mutant p53 and also to induce cell death in various cancer types. APR-246 induces apoptosis and autophagy.	Cells, 2022, 11(5)794 Hum Cell, 2022, 10.1007/s13577-022-00671-y Haematologica, 2021, 10.3324/haematol.2020.259531
S8000	Tenovin-1	Tenovin-1 protects against MDM2-mediated p53 degradation, which involves ubiquitination, and acts through inhibition of protein-deacetylating activities of SirT1 and SirT2. Tenovin-1 is also an inhibitor of dihydroorotate dehydrogenase (DHODH).	J Pharm Biomed Anal, 2021, 201:114121 J Transl Med, 2019, 17(1):76 Sci Rep, 2019, 9(1):1897
S8106	NSC59984	NSC59984 is a p53 pathway activator via induction of mutant p53 protein degradation and p73 activation.	Front Bioeng Biotechnol, 2020, 8:538663 Micromachines (Basel), 2020, 11(2)
S8149	NSC348884	NSC348884, as a nucleophosmin inhibitor, inhibit cell proliferation and induce apoptosis in various cancer cell lines with IC50 values ranging from 1.4-4 µM.	Nat Commun, 2020, 3;11(1):1669 Virulence, 2020, 11(1):1379-1393 Reproduction, 2020, 160(4):491-500
S8483	CBL0137 HCl	CBL0137 (CBLC137, Curaxin 137) HCl activates p53 and inhibits NF-kB with EC50s of 0.37 μM and 0.47 μM in the cell-based p53 and NF-kB reporter assays, respectively. It also inhibits histone chaperone FACT (facilitates chromatin transcription complex).	Cancer Lett, 2021, 520:201-212 Cancer Lett, 2021, 499:232-242 bioRxiv, 2021, 10.1101/2021.04.20.440573
S8580	COTI-2	COTI-2 is an orally available third generation thiosemicarbazone and activator of mutant forms of the p53 protein, with potential antineoplastic activity.	DASH, 2020, None
S6851	RA-190	RA190, a bis-benzylidine piperidon, is a potent, selective and oral effective inhibitor of proteasome ubiquitin receptor RPN13/ADRM1 with anticancer activity. RA190 triggers ER stress response, p53/p21 signaling axis and autophagy in multiple myeloma cells.
S6882	HI-TOPK-032	HI-TOPK-032 is a potent and specific inhibitor of TOPK. HI-TOPK-032 also reduces ERK-RSK phosphorylation, regulates of the abundance of p53, cleaved caspase-7, and cleaved PARP, and induces apoptosis in cancer cells.
E0035^New	CP-31398 Dihydrochloride	CP-31398 Dihydrochloride stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-type p53.