TACE

Other Apoptosis Related Inhibitors

Caspase Bcl-2 p53 Ferroptosis PD-1/PD-L1 Survivin TNF-alpha MDM2/MDMX KRas IAP

Cat.No.	Product Name	Information	Product Use Citations	Product Validations
S7434	TAPI-1	(S,S)-TAPI-1 is an isomer of TAPI-1. TAPI-1 is an ADAM17/TACE inhibitor, which blocks shedding of cytokine receptors. TAPI-1 is also an inhibitor of Matrix Metalloproteinase (MMP).	Nat Sci Sleep, 2025, 17:1915-1928 Br J Cancer, 2024, 10.1038/s41416-024-02576-z J Biol Chem, 2024, 300(12):107930
E1386	KP-457	KP-457 (TNF-α-converting enzyme) is a selective inhibitor of ADAM17 with IC50 of 11.1 nM/L (cell-free assay). It also cleaves various molecules such as GPIbα, GPV, and TNF-α.

Cat.No.

Product Name

Information

Product Use Citations

Product Validations

S7434

TAPI-1

(S,S)-TAPI-1 is an isomer of TAPI-1. TAPI-1 is an ADAM17/TACE inhibitor, which blocks shedding of cytokine receptors. TAPI-1 is also an inhibitor of Matrix Metalloproteinase (MMP).

Nat Sci Sleep, 2025, 17:1915-1928

Br J Cancer, 2024, 10.1038/s41416-024-02576-z

J Biol Chem, 2024, 300(12):107930

E1386

KP-457

KP-457 (TNF-α-converting enzyme) is a selective inhibitor of ADAM17 with IC50 of 11.1 nM/L (cell-free assay). It also cleaves various molecules such as GPIbα, GPV, and TNF-α.