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DAPK

Other Apoptosis Related Inhibitors

Caspase Bcl-2 p53 Ferroptosis PD-1/PD-L1 Survivin TNF-alpha MDM2/MDMX KRas IAP
Cat.No. Product Name Information Product Use Citations Product Validations
E1345 HS148 HS148 (DAPK3 inhibitor HS148) is a selective inhibitor of DAPK3 with Ki of 119 nM
J Immunol, 2021, 206 (9): 2061–2074
E1346 HS94 HS94 (DAPK3 inhibitor HS94) is a selective inhibitor of DAPK3 with Ki of 126 nM, >20-fold selectivity over Pim kinases.
S1113 GSK690693 GSK690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2 nM/13 nM/9 nM in cell-free assays, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes. GSK690693 also potently inhibits AMPK and DAPK3 from the CAMK family with IC50 of 50 nM and 81 nM, respectively. GSK690693 affects Unc-51-like autophagy activating kinase 1 (ULK1) activity, robustly inhibits STING-dependent IRF3 activation. Phase 1.
Theranostics, 2025, 15(18):9819-9837
Cell Rep, 2025, 44(7):115947
Front Cell Infect Microbiol, 2025, 15:1543186
Verified customer review of GSK690693
E1120 TC-DAPK 6 TC-DAPK 6 is a potent, ATP-competitive, and highly selective DAPK inhibitor with IC50 of 69 and 225 nM against DAPK1 and DAPK3, respectively.