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PKD

Other Apoptosis Related Inhibitors

Caspase Bcl-2 p53 Ferroptosis PD-1/PD-L1 Survivin TNF-alpha MDM2/MDMX KRas IAP
Cat.No. Product Name Information Product Use Citations Product Validations
S7188 CID755673 CID755673 is a cell-active pan-PKD1/2/3 inhibitor with IC50 of 180 nM, 280nM, and 227 nM, respectively, about 200-fold selectivity over other CAMKs.
World Allergy Organ J, 2025, 18(8):101089
J Thromb Haemost, 2024, S1538-7836(24)00618-4
Nat Commun, 2023, 14(1):3543
S8366 CRT0066101 dihydrochloride CRT0066101 dihydrochloride is a small molecule PKD family specific inhibitor which specifically blocks PKD1/2 activity and does not suppress PKCα/PKCβ/PKCε activity in multiple.
Sci Rep, 2025, 15(1):28778
Cell Rep, 2023, 42(9):113035
Cells, 2023, 12(2)212
S5792 CID 2011756 CID 2011756 is an inhibitor of protein kinase D (PKD) with IC50 values of 3.2, 0.6, and 0.7 μM for PKD1, PKD2, and PKD3, respectively.
S2642 1-Naphthyl PP1(1-NA-PP1) 1-Naphthyl PP1 (1-NA-PP1) is a highly selective and potent pan-PKD inhibitor with IC50 values of 154.6 nM, 133.4 nM, and 109.4 nM for PKD1, PKD2, and PKD3, respectively. It also acts as a selective inhibitor of Src family kinases (v-Src, c-Fyn) and the tyrosine kinase c-Abl, with IC50 values of 1.0 μM, 0.6 μM, 0.6 μM, 18 μM, and 22 μM for v-Src, c-Fyn, c-Abl, CDK2, and CAMK II, respectively.
Cancer Gene Ther, 2025, 10.1038/s41417-025-00874-z
Cell Rep, 2024, 43(1):113617