PKD

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Catalog No. Product Name Information Product Use Citations Product Validations
S2642 1-Naphthyl PP1(1-NA-PP1) 1-Naphthyl PP1(1-NA-PP 1) is a highly selective and potent pan-PKD inhibitor with IC50 of 154.6 nM,133.4 nM and 109.4 nM for PKD1, PKD2 and PKD3, respectively. 1-Naphthyl PP1 is a selective inhibitor of Src family kinases (v-Src, c-Fyn) and the tyrosine kinase c-Abl with IC50 of 1.0 μM, 0.6 μM, 0.6 μM, 18 μM and 22 μM for v-Src, c-Fyn, c-Abl, CDK2 and CAMK II, respectively.
S5792 CID 2011756 CID 2011756 is an inhibitor of protein kinase D (PKD) with IC50 values of 3.2, 0.6, and 0.7 μM for PKD1, PKD2, and PKD3, respectively.
S6532 kb-NB77-78 kb-NB77-78 is an analog of CID797718. However, it shows no inhibitory activty towards PKD1.
S7188 CID755673 CID755673 is a cell-active pan-PKD1/2/3 inhibitor with IC50 of 180 nM, 280nM, and 227 nM, respectively, about 200-fold selectivity over other CAMKs.
Nat Cell Biol, 2019, 21(6):778-790
Cancer Res, 2018, 78(18):5274-5286
Aging (Albany NY), 2018, 10(12):3736-3744
S8366 CRT0066101 dihydrochloride CRT0066101 dihydrochloride is a small molecule PKD family specific inhibitor which specifically blocks PKD1/2 activity and does not suppress PKCα/PKCβ/PKCε activity in multiple.
Cancers (Basel), 2022, 14(13)3186
Mol Cancer Res, 2021, molcanres.0808.2020
University of Stuttgart, 2020, N/A
S0199 CID 797718 CID 797718 is a potential PKD binding agent.
S2642 1-Naphthyl PP1(1-NA-PP1) 1-Naphthyl PP1(1-NA-PP 1) is a highly selective and potent pan-PKD inhibitor with IC50 of 154.6 nM,133.4 nM and 109.4 nM for PKD1, PKD2 and PKD3, respectively. 1-Naphthyl PP1 is a selective inhibitor of Src family kinases (v-Src, c-Fyn) and the tyrosine kinase c-Abl with IC50 of 1.0 μM, 0.6 μM, 0.6 μM, 18 μM and 22 μM for v-Src, c-Fyn, c-Abl, CDK2 and CAMK II, respectively.
S5792 CID 2011756 CID 2011756 is an inhibitor of protein kinase D (PKD) with IC50 values of 3.2, 0.6, and 0.7 μM for PKD1, PKD2, and PKD3, respectively.
S6532 kb-NB77-78 kb-NB77-78 is an analog of CID797718. However, it shows no inhibitory activty towards PKD1.
S7188 CID755673 CID755673 is a cell-active pan-PKD1/2/3 inhibitor with IC50 of 180 nM, 280nM, and 227 nM, respectively, about 200-fold selectivity over other CAMKs.
Nat Cell Biol, 2019, 21(6):778-790
Cancer Res, 2018, 78(18):5274-5286
Aging (Albany NY), 2018, 10(12):3736-3744
S8366 CRT0066101 dihydrochloride CRT0066101 dihydrochloride is a small molecule PKD family specific inhibitor which specifically blocks PKD1/2 activity and does not suppress PKCα/PKCβ/PKCε activity in multiple.
Cancers (Basel), 2022, 14(13)3186
Mol Cancer Res, 2021, molcanres.0808.2020
University of Stuttgart, 2020, N/A
S0199 CID 797718 CID 797718 is a potential PKD binding agent.
Tags: PKD inhibitor|PKD agonist|PKD activator|PKD inducer|PKD antagonist|PKD signaling pathway|PKD assay kit