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RIP kinase

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Isoform-selective Products

Cat.No. Product Name Information Product Use Citations Product Validations
S8037 Necrostatin-1 (Nec-1) Necrostatin-1 (Nec-1) is a specific RIP1 (RIPK1) inhibitor and inhibits TNF-α-induced necroptosis with EC50 of 490 nM in 293T cells. Necrostatin-1 also blocks IDO and suppresses autophagy and apoptosis.
Cell Res, 2025, 10.1038/s41422-025-01167-8
Signal Transduct Target Ther, 2025, 10(1):341
Cancer Discov, 2025, 10.1158/2159-8290.CD-24-1317
Verified customer review of Necrostatin-1 (Nec-1)
S8641 Necrostatin 2 racemate (Nec-1s) Necrostatin 2 racemate (Nec-1s, 7-Cl-O-Nec1, Necrostatin-1 stable, Necrostatin 1S) is a stable variant of Necrostatin-1. This compound is a more specific RIPK1 inhibitor lacking the IDO-targeting effect, with >1000-fold more selective for RIPK1 than for any other kinase out of 485 human kinases.
Nature, 2025, 10.1038/s41586-025-09741-1
Cell, 2025, S0092-8674(25)01233-4
Cancer Cell, 2025, S1535-6108(25)00132-1
S8465 GSK872 GSK'872 is a potent and selective RIP3 kinase inhibitor which binds RIP3 kinase domain with high affinity (IC50=1.8 nM) and inhibits kinase activity with IC50 of 1.3 nM. It has minimal cross-reactivity.
Nature, 2025, 647(8090):735-746
Nature, 2025, 10.1038/s41586-025-09741-1
Cell Res, 2025, 10.1038/s41422-025-01167-8
Verified customer review of GSK872
S9733 Mito-TEMPO Mito-TEMPO (MT), a mitochondria-targeted superoxide dismutase mimetic, protects against the early phase of acetaminophen (APAP) hepatotoxicity by inhibiting peroxynitrite formation. Mito-TEMPO treatment inhibits APAP-induced RIP3 kinase expression.
Clin Transl Med, 2025, 15(1):e70180
J Biol Chem, 2025, 301(10):110653
Nat Commun, 2024, 15(1):1669
S8642 GSK'963 GSK'963 is a chiral small-molecule inhibitor of RIP1 kinase (RIPK1) with an IC50 of 29 nM in FP binding assays. It is >10 000-fold selective for RIP1 over 339 other kinases.
Proceedings of the National Academy of Sciences, February 18, 2025, e2420802122
eLife, December 06, 2021, e73137
PLoS Biol, 2025, 23(2):e3002845
S6511 RIPA-56 RIPA-56 is a highly-potent, selective, and metabolically stable RIP1 (RIPK1) inhibitor.
Journal of Oncology, July 11, 2022, 2390078
European Journal of Pharmacology, December 15, 2022, 175381
Cell Genom, 2024, 4(2):100487
S8484 GSK2982772 GSK2982772 is an ATP competitive receptor-interacting protein-1 (RIP1) kinase (RIPK1) inhibitor with the IC50 value of 16 nM. It has exquisite kinase specificity and excellent activity in blocking many TNF-dependent cellular responses.
Antioxidants, 2021, 1347
Antioxidants (Basel), 2021, 10(9)1347
Mol Cell Biochem, 2021, 10.1007/s11010-021-04136-y
S8261 GSK583 GSK583 is a highly potent and selective inhibitor of RIP2 kinase with IC50 of 5 nM. This compound also inhibits both TNF-α and IL-6 production with IC50 of ~200 nM in explant cultures.
J Invest Dermatol, 2025, S0022-202X(25)00494-4
Dissertation, Universität Regensburg, 2022, Unknown
Cancer Res, 2020, canres.530.2020
S3238 Resibufogenin Resibufogenin (Bufogenin, Recibufogenin), a component of huachansu with anticancer effect, triggers necroptosis through upregulating receptor-interacting protein kinase 3 (RIP3) and phosphorylating mixed lineage kinase domain-like protein at Ser358. This compound exerts cytotoxic effect by inducing reactive oxygen species (ROS) accumulation. It induces apoptosis and caspase-3 and caspase-8 activity. This chemical increases Bax/Bcl-2 expression, and suppresses cyclin D1, cyclin E, PI3K, p-AKT, p-GSK3β and β-catenin protein expression.
bioRxiv, 2025, 2025.07.17.665404
Research Square, 2024, 10.21203/rs.3.rs-3790060/v1
Phytomedicine, 2022, 102:154182
S6078 ICCB-19 hydrochloride ICCB-19 hydrochloride is an inhibitor of TNFRSF1A Associated Via Death Domain (TRADD) with IC50 of 1.12 μM and 2.01 μM for protecting Velcade-induced apoptosis in Jurkat cells and protecting RDA in MEFs, respectively. ICCB-19 indirectly inhibits Receptor-interacting serine/threonine-protein kinase 1 (RIPK1). ICCB-19 effectively induces autophagy.
The EMBO Journal, 2025, 6196-6225
EMBO J, 2025, 10.1038/s44318-025-00561-7
The EMBO Journal, 2025, 6196-6225