Home Apoptosis Heme Oxygenase

Heme Oxygenase

Other Apoptosis Related Inhibitors

Caspase Bcl-2 p53 Ferroptosis PD-1/PD-L1 Survivin TNF-alpha MDM2/MDMX KRas IAP

Isoform-selective Products

Cat.No. Product Name Information Product Use Citations Product Validations
S5645 Hemin Hemin (protohemin) is an iron-containing porphyrin used in the management of porphyria attacks, particularly in acute intermittent porphyria.This compound is an Heme oxygenase (HO)-1 inducer.This product has poor solubility, animal experiments are available, cell experiments please choose carefully!
Sci Rep, 2025, 15(1):13159
Biochem J, 2025, 482(12):859-75
Hum Cell, 2024, 10.1007/s13577-024-01034-5
S7880 Protoporphyrin IX Zinc Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) is an potent, orally active and competitive heme oxygenase-1 (HO-1) inhibitor and significantly reduces the protective effects of Phloroglucinol (PG) against hydrogen peroxide.This product has poor solubility, animal experiments are available, cell experiments please choose carefully!
Sci Rep, 2025, 15(1):18949
Nat Commun, 2024, 15(1):9050
S9503 Fraxetin Fraxetin (7,8-dihydroxy-6-methoxy coumarin), found in Fraxinus rhynchophylla, shows potent antioxidant activity.fraxetin alleviates lipid peroxidation, enhances hepatic antioxidant capabilities, inhibits CYP2E1 activity, and reduced the inflammatory mediators, including TNF-α and IL-1β via up-regulation of hemeoxygenase-1 (HO-1) protein.
Life (Basel), 2023, 13(5)1112
S9221 Ferulaldehyde Ferulaldehyde (Coniferaldehyde, Ferulyl aldehyde) is a natural intermediate of polyphenol metabolism of intestinal microflora.
S7879 Tin protoporphyrin IX dichloride Tin Protoporphyrin IX dichloride (NSC 267099, SnPPIX, Sn-Protoporphyrin) is a potent inhibitor of heme oxygenase-1 (HO-1), reduces ozone-induced pulmonary inflammation and BAL cell necrosis, highlighting its protective role. It also sensitizes pancreatic ductal adenocarcinoma (PDAC) tumors to chemotherapy in a mouse model, suggesting its potential for PDAC treatment.
E3438 Momordica grosvenori Extract Momordica Grosvenori Extract is extracted from Siraitia grosvenorii, which has antidiabetic effects by upregulating HO-1 and can be used for the treatment of diabetes.
S5771 Sulforaphane Sulforaphane is a naturally occurring isothiocyanate derived from the consumption of cruciferous vegetables, such as broccoli, cabbage, and kale. It is an inducer of Nrf2. This compound is also an inhibitor of histone deacetylase (HDAC) and NF-κB. It increases heme oxygenase-1 (HO-1) and reduces the levels of reactive oxygen species (ROS). It induces cell cycle arrest and apoptosis.
J Clin Invest, 2025, 135(14)e176655
Sci Rep, 2025, 15(1):21271
BMC Cancer, 2025, 25(1):1050
E0526 sappanone A Sappanone A, a homoisoflavanone isolated from the heartwood of Caesalpinia sappan (Leguminosae), induces HO-1 expression by activating Nrf2 through the p38 MAPK pathway, suppresses LPS-induced NF-κB activation by suppressing the phosphorylation of RelA/p65 at Ser536, exerting its anti-inflammatory effect.