PFKFB

Home Cell Cycle -Apoptosis PFKFB

Isoform-selective Products

PFKFB Products

  • All (8)
  • PFKFB Inhibitors (4)
  • New PFKFB Products
Catalog No. Product Name Information Product Use Citations Product Validations
S7289 PFK15 PFK15 (PFK-015) is a potent and selective 6-phosphofructo-2-kinase (PFKFB3) inhibitor with IC50 of 207 nM.
Nature, 2025, 10.1038/s41586-025-09328-w
Adv Healthc Mater, 2025, e2501417.
Cell Commun Signal, 2025, 23(1):104
PFK15 Customer Review
S7639 3PO 3PO (3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one) is a small-molecule inhibitor of PFKFB3 with an IC50 of 22.9 μM for recombinant human PFKFB3 protein and does not inhibit PFK-1 activity. It suppresses glucose uptake, and decreases the intracellular concentration of Fru-2,6-BP, lactate, ATP, NAD+, and NADH.
Atherosclerosis, 2025, 405:119223
J Transl Med, 2024, 22(1):954
Respir Res, 2022, 23(1):75
S8807 PFK158 PFK158 is a potent and selective inhibitor of PFKFB3. It has improved PK properties and causes ~80% growth inhibition in several mouse models of human-derived tumors.
bioRxiv, 2025, 2025.05.25.655979
Life Med, 2023, 2(1):lnad006
Nat Metab, 2022, 4(10):1287-1305
S0400 KAN0438757 KAN0438757 is a potent and selective inhibitor of the metabolic kinase PFKFB3 (6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3) with IC50 of 0.19 μM and 3.6 μM for PFKFB3 and PFKFB4, respectively.
Mol Cell Proteomics, 2023, 22(11):100649
Mol Cell Proteomics, 2023, 10.1016/j.mcpro.2023.100649
F1204 PFKFB3 Antibody [M5H12] 6 Phosphofructo 2 Kinase,PFKFB3
J Inflamm Res, 2022, 15:2121-2139
Am J Cancer Res, 2021, 11(3):793-811
F0698 PFKP Antibody [E13C9]
F2565New PFKM Antibody [F13D16] PFK-1,PFKM
F0903 Phospho-PFKFB2 (Ser483) Antibody [A5G21]
S7289 PFK15 PFK15 (PFK-015) is a potent and selective 6-phosphofructo-2-kinase (PFKFB3) inhibitor with IC50 of 207 nM.
Nature, 2025, 10.1038/s41586-025-09328-w
Adv Healthc Mater, 2025, e2501417.
Cell Commun Signal, 2025, 23(1):104
 Verified customer review of PFK15
S7639 3PO 3PO (3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one) is a small-molecule inhibitor of PFKFB3 with an IC50 of 22.9 μM for recombinant human PFKFB3 protein and does not inhibit PFK-1 activity. It suppresses glucose uptake, and decreases the intracellular concentration of Fru-2,6-BP, lactate, ATP, NAD+, and NADH.
Atherosclerosis, 2025, 405:119223
J Transl Med, 2024, 22(1):954
Respir Res, 2022, 23(1):75
S8807 PFK158 PFK158 is a potent and selective inhibitor of PFKFB3. It has improved PK properties and causes ~80% growth inhibition in several mouse models of human-derived tumors.
bioRxiv, 2025, 2025.05.25.655979
Life Med, 2023, 2(1):lnad006
Nat Metab, 2022, 4(10):1287-1305
S0400 KAN0438757 KAN0438757 is a potent and selective inhibitor of the metabolic kinase PFKFB3 (6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3) with IC50 of 0.19 μM and 3.6 μM for PFKFB3 and PFKFB4, respectively.
Mol Cell Proteomics, 2023, 22(11):100649
Mol Cell Proteomics, 2023, 10.1016/j.mcpro.2023.100649
F2565New PFKM Antibody [F13D16] PFK-1,PFKM

Choose Selective PFKFB Inhibitors