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PFKFB

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Isoform-selective Products

Cat.No. Product Name Information Product Use Citations Product Validations
S7289 PFK-015 PFK15 (PFK-015) is a potent and selective 6-phosphofructo-2-kinase (PFKFB3) inhibitor with IC50 of 207 nM.
Nature, 2025, 10.1038/s41586-025-09328-w
Adv Healthc Mater, 2025, e2501417.
Cell Commun Signal, 2025, 23(1):104
Verified customer review of PFK-015
S7639 3PO 3PO (3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one) is a small-molecule inhibitor of PFKFB3 with an IC50 of 22.9 μM for recombinant human PFKFB3 protein and does not inhibit PFK-1 activity. It suppresses glucose uptake, and decreases the intracellular concentration of Fru-2,6-BP, lactate, ATP, NAD+, and NADH.
Atherosclerosis, 2025, 405:119223
bioRxiv, 2025, nan
J Transl Med, 2024, 22(1):954
S8807 PFK158 PFK158 is a potent and selective inhibitor of PFKFB3. It has improved PK properties and causes ~80% growth inhibition in several mouse models of human-derived tumors.
Cancer & Metabolism, September 23, 2021, 33
eLife, September 09, 2025, 107536
Frontiers in Cellular and Infection Microbiology, October 08, 2025, 1648576
S0400 KAN0438757 KAN0438757 is a potent and selective inhibitor of the metabolic kinase PFKFB3 (6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3) with IC50 of 0.19 μM and 3.6 μM for PFKFB3 and PFKFB4, respectively.
Current Issues in Molecular Biology, 2025, 892
Molecular & Cellular Proteomics, 2023, 100649
Mol Cell Proteomics, 2023, 22(11):100649