PFKFB

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Catalog No. Product Name Information Product Use Citations Product Validations
S0400 KAN0438757 KAN0438757 is a potent and selective inhibitor of the metabolic kinase PFKFB3 (6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3) with IC50 of 0.19 μM and 3.6 μM for PFKFB3 and PFKFB4, respectively.
S7289 PFK15 PFK15 (PFK-015) is a potent and selective 6-phosphofructo-2-kinase (PFKFB3) inhibitor with IC50 of 207 nM.
J Exp Clin Cancer Res, 2022, 41(1):77
Acta Biomater, 2022, 148:181-193
Cancer Lett, 2022, S0304-3835(22)00055-6
S7639 3PO 3PO (3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one) is a small-molecule inhibitor of PFKFB3 with an IC50 of 22.9 μM for recombinant human PFKFB3 protein and does not inhibit PFK-1 activity. It suppresses glucose uptake, and decreases the intracellular concentration of Fru-2,6-BP, lactate, ATP, NAD+, and NADH.
Exp Neurol, 2021, 347:113871
Lab Invest, 2021, 10.1038/s41374-021-00701-7
Neoplasma, 2021, 68(1):71-78
S8807 PFK158 PFK158 is a potent and selective inhibitor of PFKFB3. It has improved PK properties and causes ~80% growth inhibition in several mouse models of human-derived tumors.
Front Oncol, 2022, 12:826655
Front Immunol, 2021, 12:669456
Cancer Metab, 2021, 9(1):33
S0400 KAN0438757 KAN0438757 is a potent and selective inhibitor of the metabolic kinase PFKFB3 (6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3) with IC50 of 0.19 μM and 3.6 μM for PFKFB3 and PFKFB4, respectively.
S7289 PFK15 PFK15 (PFK-015) is a potent and selective 6-phosphofructo-2-kinase (PFKFB3) inhibitor with IC50 of 207 nM.
J Exp Clin Cancer Res, 2022, 41(1):77
Acta Biomater, 2022, 148:181-193
Cancer Lett, 2022, S0304-3835(22)00055-6
S7639 3PO 3PO (3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one) is a small-molecule inhibitor of PFKFB3 with an IC50 of 22.9 μM for recombinant human PFKFB3 protein and does not inhibit PFK-1 activity. It suppresses glucose uptake, and decreases the intracellular concentration of Fru-2,6-BP, lactate, ATP, NAD+, and NADH.
Exp Neurol, 2021, 347:113871
Lab Invest, 2021, 10.1038/s41374-021-00701-7
Neoplasma, 2021, 68(1):71-78
S8807 PFK158 PFK158 is a potent and selective inhibitor of PFKFB3. It has improved PK properties and causes ~80% growth inhibition in several mouse models of human-derived tumors.
Front Oncol, 2022, 12:826655
Front Immunol, 2021, 12:669456
Cancer Metab, 2021, 9(1):33
Tags: PFKFB inhibitor|PFKFB agonist|PFKFB activator|PFKFB inducer|PFKFB antagonist|PFKFB signaling pathway|PFKFB assay kit