PFKFB

All (4) PFKFB Inhibitors (4)

Catalog No.	Information	Product Use Citations	Product Validations
S7289	PFK15 PFK15 (PFK-015) is a potent and selective 6-phosphofructo-2-kinase (PFKFB3) inhibitor with IC50 of 207 nM.	PLoS Pathog, 2021, 17(2):e1009303 ACS Appl Mater Interfaces, 2020, 6 J Cell Mol Med, 2020, 24(3):2294-2307	b EdU incorporation assays indicated PFK15 inhibited the cell proliferation of Cal27 cells. c The quantitative data of the EdU incorporation assays.
S7639	3PO 3PO (3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one) is a small-molecule inhibitor of PFKFB3 with an IC50 of 22.9 μM for recombinant human PFKFB3 protein and does not inhibit PFK-1 activity. It suppresses glucose uptake, and decreases the intracellular concentration of Fru-2,6-BP, lactate, ATP, NAD+, and NADH.	Neoplasma, 2021, 68(1):71-78 Lab Invest, 2020, 100(6):801-811 Lab Invest, 2020, 10.1038/s41374-020-0404-9
S8807	PFK158 PFK158 is a potent and selective inhibitor of PFKFB3. It has improved PK properties and causes ~80% growth inhibition in several mouse models of human-derived tumors.	Cell Metab, 2020, 5;31(5):937-955e7
S0400^New	KAN0438757 KAN0438757 is a potent and selective inhibitor of the metabolic kinase PFKFB3 (6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3) with IC50 of 0.19 μM and 3.6 μM for PFKFB3 and PFKFB4, respectively.

Catalog No.	Information	Product Use Citations	Product Validations
S7289	PFK15 PFK15 (PFK-015) is a potent and selective 6-phosphofructo-2-kinase (PFKFB3) inhibitor with IC50 of 207 nM.	PLoS Pathog, 2021, 17(2):e1009303 ACS Appl Mater Interfaces, 2020, 6 J Cell Mol Med, 2020, 24(3):2294-2307	b EdU incorporation assays indicated PFK15 inhibited the cell proliferation of Cal27 cells. c The quantitative data of the EdU incorporation assays.
S7639	3PO 3PO (3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one) is a small-molecule inhibitor of PFKFB3 with an IC50 of 22.9 μM for recombinant human PFKFB3 protein and does not inhibit PFK-1 activity. It suppresses glucose uptake, and decreases the intracellular concentration of Fru-2,6-BP, lactate, ATP, NAD+, and NADH.	Neoplasma, 2021, 68(1):71-78 Lab Invest, 2020, 100(6):801-811 Lab Invest, 2020, 10.1038/s41374-020-0404-9
S8807	PFK158 PFK158 is a potent and selective inhibitor of PFKFB3. It has improved PK properties and causes ~80% growth inhibition in several mouse models of human-derived tumors.	Cell Metab, 2020, 5;31(5):937-955e7
S0400^New	KAN0438757 KAN0438757 is a potent and selective inhibitor of the metabolic kinase PFKFB3 (6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3) with IC50 of 0.19 μM and 3.6 μM for PFKFB3 and PFKFB4, respectively.