PFKFB

Other Cell Cycle Related Inhibitors

CDK ROCK Wee1 Aurora Kinase Chk PLK APC MPS1 Rho Myc

PFKFB3 PFKFB4

Cat.No.	Product Name	Information	Product Use Citations
S7289	PFK15	PFK15 (PFK-015) is a potent and selective 6-phosphofructo-2-kinase (PFKFB3) inhibitor with IC50 of 207 nM.	Nature, 2025, 10.1038/s41586-025-09328-w Adv Healthc Mater, 2025, e2501417. Cell Commun Signal, 2025, 23(1):104
S7639	3PO	3PO (3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one) is a small-molecule inhibitor of PFKFB3 with an IC50 of 22.9 μM for recombinant human PFKFB3 protein and does not inhibit PFK-1 activity. It suppresses glucose uptake, and decreases the intracellular concentration of Fru-2,6-BP, lactate, ATP, NAD+, and NADH.	Atherosclerosis, 2025, 405:119223 J Transl Med, 2024, 22(1):954 bioRxiv, 2023, 10.1101/2023.08.01.551011
S8807	PFK158	PFK158 is a potent and selective inhibitor of PFKFB3. It has improved PK properties and causes ~80% growth inhibition in several mouse models of human-derived tumors.	bioRxiv, 2025, 2025.05.25.655979 Life Med, 2023, 2(1):lnad006 Nat Metab, 2022, 4(10):1287-1305
S0400	KAN0438757	KAN0438757 is a potent and selective inhibitor of the metabolic kinase PFKFB3 (6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3) with IC50 of 0.19 μM and 3.6 μM for PFKFB3 and PFKFB4, respectively.	Mol Cell Proteomics, 2023, 22(11):100649 Mol Cell Proteomics, 2023, 10.1016/j.mcpro.2023.100649 Research Square, 2023, Version 1