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Catalog No. Product Name Information Product Use Citations Product Validations
S0067 GS-444217 GS-444217 (ASK1-IN-1) is a potent, selective, orally available and ATP-competitive inhibitor of ASK1 (apoptosis signal-regulating kinase 1) with IC50 of 2.87 nM.
S8289 NQDI-1 NQDI 1, an inhibitor of ASK1(apoptosis signal-regulating kinase 1), attenuates acute ischemic renal injury by modulating oxidative stress and cell death.
Cell Death Dis, 2022, 13(3):197
Arterioscler Thromb Vasc Biol, 2022, 42(5):580-596
JCI Insight, 2020, 136496
S8292 Selonsertib (GS-4997) Selonsertib (GS-4997) is a highly selective and potent once-daily oral ASK1 inhibitor with potential anti-inflammatory, antineoplastic and anti-fibrotic activities.
Commun Biol, 2022, 5(1):326
Redox Biol, 2021, 45:102043
Cell Death Dis, 2021, 12(11):980
S0067 GS-444217 GS-444217 (ASK1-IN-1) is a potent, selective, orally available and ATP-competitive inhibitor of ASK1 (apoptosis signal-regulating kinase 1) with IC50 of 2.87 nM.
S8289 NQDI-1 NQDI 1, an inhibitor of ASK1(apoptosis signal-regulating kinase 1), attenuates acute ischemic renal injury by modulating oxidative stress and cell death.
Cell Death Dis, 2022, 13(3):197
Arterioscler Thromb Vasc Biol, 2022, 42(5):580-596
JCI Insight, 2020, 136496
S8292 Selonsertib (GS-4997) Selonsertib (GS-4997) is a highly selective and potent once-daily oral ASK1 inhibitor with potential anti-inflammatory, antineoplastic and anti-fibrotic activities.
Commun Biol, 2022, 5(1):326
Redox Biol, 2021, 45:102043
Cell Death Dis, 2021, 12(11):980
Tags: ASK inhibition | ASK cancer | ASK activation | ASK target | ASK tumor | ASK phosphorylation | ASK activity | ASK inhibitor drugs | ASK kinase assay | ASK inhibitor cancer | ASK inhibitor therapy | ASK signaling pathway | ASK inhibitor review