Phospholipase (e.g. PLA)

Signaling Pathway Map

Research Area

Inhibitory Selectivity

Phospholipase (e.g. PLA) Products

Catalog No. Information Product Use Citations Product Validations
S1110

Varespladib (LY315920)

Varespladib (LY315920) is a potent and selective human non-pancreatic secretory phospholipase A2 (hnsPLA) inhibitor with IC50 of 7 nM. Phase 3.

S4089

Halobetasol Propionate

Halobetasol Propionate is an anti-inflammatory and a dermatologic agent commonly used to treat psoriasis.

S4255

Quinacrine 2HCl

Quinacrine 2HCl is a lipophilic cationic drug with multiple actions that is commonly used as an anti-protozoal agent. Quinacrine is an effective phospholipase A2 inhibitor.

S8011

U73122

U73122 is a potent phospholipase C (PLC) inhibitor, which reduces agonist-induced Ca2+ increases in platelets and PMN.

S2390

Polydatin

Polydatin is a crystal component extracted from the root stem of perennial herbage Polygonum Cuspidatum Sieb.et Zucc.

S7520

Darapladib (SB-480848)

Darapladib (SB-480848) is a reversible lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor with IC50 of 0.25 nM. Phase 3.

S2364

Tanshinone I

Tanshinone I, an active principle isolated from Salvia miltiorrhiza (Danshen), is structurally similar to tanshinone IIA and may possess similar cytotoxic effects on tumor cells.

S4107

Clofazimine

Clofazimine is a rhimophenazine dye, originally developed for the treatment of tuberculosis, it has both antimicrobial and antiinflammatory activity, postulated mechanisms of action include intercalation of clofazimine with bacterial DNA and increasing levels of cellular phospholipase A2.

Catalog No. Information Product Use Citations Product Validations
S1110

Varespladib (LY315920)

Varespladib (LY315920) is a potent and selective human non-pancreatic secretory phospholipase A2 (hnsPLA) inhibitor with IC50 of 7 nM. Phase 3.

S4089

Halobetasol Propionate

Halobetasol Propionate is an anti-inflammatory and a dermatologic agent commonly used to treat psoriasis.

S4255

Quinacrine 2HCl

Quinacrine 2HCl is a lipophilic cationic drug with multiple actions that is commonly used as an anti-protozoal agent. Quinacrine is an effective phospholipase A2 inhibitor.

S8011

U73122

U73122 is a potent phospholipase C (PLC) inhibitor, which reduces agonist-induced Ca2+ increases in platelets and PMN.

S2390

Polydatin

Polydatin is a crystal component extracted from the root stem of perennial herbage Polygonum Cuspidatum Sieb.et Zucc.

S7520

Darapladib (SB-480848)

Darapladib (SB-480848) is a reversible lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor with IC50 of 0.25 nM. Phase 3.

S2364

Tanshinone I

Tanshinone I, an active principle isolated from Salvia miltiorrhiza (Danshen), is structurally similar to tanshinone IIA and may possess similar cytotoxic effects on tumor cells.

Catalog No. Information Product Use Citations Product Validations
S4107

Clofazimine

Clofazimine is a rhimophenazine dye, originally developed for the treatment of tuberculosis, it has both antimicrobial and antiinflammatory activity, postulated mechanisms of action include intercalation of clofazimine with bacterial DNA and increasing levels of cellular phospholipase A2.