Phospholipase (e.g. PLA)
- Inhibitory Selectivity
|Catalog No.||Product Name||Solubility(25°C)|
|S1110||Varespladib (LY315920)||<1 mg/mL||76 mg/mL||<1 mg/mL|
|S4089||Halobetasol Propionate||<1 mg/mL||97 mg/mL||38 mg/mL|
|S4255||Quinacrine 2HCl||53 mg/mL||14 mg/mL||28 mg/mL|
|S8011||U73122||<1 mg/mL||0.01 mg/mL||<1 mg/mL|
|S2390||Polydatin||<1 mg/mL||78 mg/mL||<1 mg/mL|
|S7520||Darapladib (SB-480848)||<1 mg/mL||100 mg/mL||100 mg/mL|
|S2364||Tanshinone I||<1 mg/mL||23 mg/mL||<1 mg/mL|
|S4107||Clofazimine||<1 mg/mL||5 mg/mL||<1 mg/mL|
- Phospholipase (e.g. PLA) Inhibitors (8)
|Catalog No.||Information||Product Use Citations||Product Validations|
Varespladib (LY315920) is a potent and selective human non-pancreatic secretory phospholipase A2 (hnsPLA) inhibitor with IC50 of 7 nM. Phase 3.
After serum deprivation for 48 h (A) or 24 h (B) MDA-MB-231 cells were treated with recombinant hGX (10 nM) in serum-free medium containing 0.1% FAF BSA for 24 h (A) or 96 h (B) in the presence or absence of the sPLA2 inhibitor varespladib (Var) at a final concentration of 50 μM.
Halobetasol Propionate is an anti-inflammatory and a dermatologic agent commonly used to treat psoriasis.
Quinacrine 2HCl is a lipophilic cationic drug with multiple actions that is commonly used as an anti-protozoal agent. Quinacrine is an effective phospholipase A2 inhibitor.
U73122 is a potent phospholipase C (PLC) inhibitor, which reduces agonist-induced Ca2+ increases in platelets and PMN.
Effect of U73122 and XC on TFEB phosphorylation
Polydatin is a crystal component extracted from the root stem of perennial herbage Polygonum Cuspidatum Sieb.et Zucc.
Darapladib (SB-480848) is a reversible lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor with IC50 of 0.25 nM. Phase 3.
Tanshinone I, an active principle isolated from Salvia miltiorrhiza (Danshen), is structurally similar to tanshinone IIA and may possess similar cytotoxic effects on tumor cells.
Tan-1 inhibited the migration of HMEC-1 cells (F). Cells were treated with vehicle (a), or Tan-1 12.5 μM (b), 25 μM (c) or 50 μM (d) in the corresponding left panel for 6 h. Magnification: 10×. The data from three independent experiments were expressed as mean ± SD in the corresponding right panel. *p < 0.05; **p < 0.01.
Clofazimine is a rhimophenazine dye, originally developed for the treatment of tuberculosis, it has both antimicrobial and antiinflammatory activity, postulated mechanisms of action include intercalation of clofazimine with bacterial DNA and increasing levels of cellular phospholipase A2.