Phospholipase (e.g. PLA)

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Phospholipase (e.g. PLA) Signaling Pathway Map

Phospholipase (e.g. PLA) Signaling Pathways

Phospholipase (e.g. PLA) Products

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  • Phospholipase (e.g. PLA) Inhibitors (15)
  • Phospholipase (e.g. PLA) Antibodie (1)
  • Phospholipase (e.g. PLA) Activators (3)
  • Phospholipase (e.g. PLA) Antagonist (1)
  • New Phospholipase (e.g. PLA) Products
Catalog No. Product Name Information Product Use Citations Product Validations
S0766 RHC 80267 RHC 80267 (U-57908) is a potent and selective inhibitor of diacylglycerol lipase (DAGL, DAG lipase) with IC50 of 4 μM for cholinesterase activity. RHC 80267 inhibits cyclooxygenase (COX) activity, phospholipase C (PLC) activity and the hydrolysis of phosphatidylcholine (PC).
S1110 Varespladib (LY315920) Varespladib (LY315920) is a potent and selective human non-pancreatic secretory phospholipase A2 (hnsPLA) inhibitor with IC50 of 7 nM. Phase 3.
Front Immunol, 2022, 13:824746
J Med Chem, 2019, 62(4):1999-2007
J Med Chem, 2019, 62(4):1999-2007
S2364 Tanshinone I Tanshinone I, an active principle isolated from Salvia miltiorrhiza (Danshen), is structurally similar to tanshinone IIA and may possess similar cytotoxic effects on tumor cells.
Phytomedicine, 2022, 98:153958
Mol Med Rep, 2021, 23(1)40
Int Immunopharmacol, 2019, 10.1016/j.intimp.2019.106040
S2390 Polydatin Polydatin (Piceid) is a crystal component extracted from the root stem of perennial herbage Polygonum Cuspidatum Sieb.et Zucc.
Biochem Biophys Res Commun, 2021, 556:149-155
J Med Virol, 2019, 91(8):1440-1447
S3220 Trigonelline Trigonelline (Trigenolline) is a plant alkaloid and a major component of coffee and fenugreek with anti-degranulation, anti-diabetic, antioxidant, anti-inflammatory, and neuroprotective effects. Trigonelline inhibits FcεRI-mediated intracellular signaling pathways, such as phosphorylation of PLCγ1, PI3K, and Akt. Trigonelline (Trigenolline) also inhibits the microtubule formation in RBL-2H3 cells.
Biomed Pharmacother, 2021, 143:112204
S4089 Halobetasol Propionate Halobetasol Propionate (BMY-30056, CGP-14458) is an anti-inflammatory and a dermatologic agent commonly used to treat psoriasis. Halobetasol propionate is thought to act by the induction of phospholipase A2 (PLA2) inhibitory proteins.
S4255 Quinacrine 2HCl Quinacrine 2HCl is a lipophilic cationic drug with multiple actions that is commonly used as an anti-protozoal agent. Quinacrine is an effective phospholipase A2 inhibitor.
Toxicol In Vitro, 2022, 83:105420
Mol Oncol, 2020, 10.1002/1878-0261.12853
Mol Oncol, 2020, 10.1002/1878-0261.12853
S5913 Cambinol Cambinol is a novel uncompetitive nSMase2 inhibitor with a K i value of 7 μM (IC50 = 5 ± 1 μM).
S6522 ST 271 ST271 is a tyrphostin-like protein tyrosine kinase (PTK) inhibitor which inhibits phospholipase D (PLD) activity.
S6564 ML348 ML348 (GNF-Pf-1127) is a potent and selective APT1 (Acyl protein thioesterase 1)/lysophospholipase 1 (LYPLA1) inhibitor with Ki values of 280 nM and >10 μM for APT1 and APT2, respectively.
S7321 FIPI FIPI (5-Fluoro-2-indolyl deschlorohalopemide), a derivative of halopemide, is a potent and selective inhibitor of phospholipase D with IC50 of 25 nM and 20 nM for PLD1 and PLD2, respectively.
S7520 Darapladib (SB-480848) Darapladib (SB-480848) is a reversible lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor with IC50 of 0.25 nM. Phase 3.
Signal Transduct Target Ther, 2022, 7(1):59
Nat Metab, 2021, 3(6):762-773
Biochem Pharmacol, 2016, 102:78-96
S7609 GW4869 GW4869 (GW69A, GW554869A) is a neutral, noncompetitive inhibitor of sphingomyelinase (SMase) with an IC50 of 1 μM. It is selective for N-SMase, and does not inhibit acid SMase at up to at least 150 μM, also is a commonly used exosome inhibitor.
Front Cell Neurosci, 2022, 16:832140
Arthritis Res Ther, 2022, 24(1):44
FEBS J, 2022, 10.1111/febs.16447
S8011 U73122 U73122 is a potent phospholipase C (PLC) inhibitor, which reduces agonist-induced Ca2+ increases in platelets and PMN. U73122 potently inhibits human 5-lipoxygenase (5-LO).
J Exp Clin Cancer Res, 2022, 41(1):210
J Nanobiotechnology, 2022, 20(1):314
Cancers (Basel), 2022, 14(9)2222
S9478 Trans-4-Phenyl-3-buten-2-one Trans-4-Phenyl-3-buten-2-one (trans-Benzylideneacetone, trans-Benzalacetone, trans-Benzylideneacetone) is an inhibitor of the enzyme phospholipase A2 (PLA2). Trans-4-Phenyl-3-buten-2-one is used as a flavouring agent, a fragrance and a bacterial metabolite.
A5277 PLCG1 Rabbit Recombinant mAb PLCG1 Rabbit Recombinant mAb detects endogenous level of total PLCG1.
S0982 m-3M3FBS m-3M3FBS is a potent activator of phospholipase C (PLC) that stimulates a transient intracellular calcium concentration increase in neutrophils. m-3M3FBS induces apoptosis in monocytic leukemia cells.
S4107 Clofazimine Clofazimine (NSC-141046) is a rhimophenazine dye, originally developed for the treatment of tuberculosis, it has both antimicrobial and antiinflammatory activity, postulated mechanisms of action include intercalation of clofazimine with bacterial DNA and increasing levels of cellular phospholipase A2.
Blood, 2022, blood.2021014304
Microorganisms, 2022, 10(7)1421
ACS Infect Dis, 2020, acsinfecdis.0c00486
S9794 Melittin Melittin (MLT, Forapin, Forapine) is an activator of phospholipase A2 (PLA2) that stimulates the activity of the low molecular weight PLA2, while it does not the increase the activity of the high molecular weight enzyme.
EMBO J, 2022, e110439
S0053 CAY10593 (VU0155069) CAY10593 (VU0155069) is a selective phospholipase D1 (PLD1) antagonist that impairs human P2X7 acivation.
Free Radic Biol Med, 2021, S0891-5849(21)00821-2
S0766 RHC 80267 RHC 80267 (U-57908) is a potent and selective inhibitor of diacylglycerol lipase (DAGL, DAG lipase) with IC50 of 4 μM for cholinesterase activity. RHC 80267 inhibits cyclooxygenase (COX) activity, phospholipase C (PLC) activity and the hydrolysis of phosphatidylcholine (PC).
S1110 Varespladib (LY315920) Varespladib (LY315920) is a potent and selective human non-pancreatic secretory phospholipase A2 (hnsPLA) inhibitor with IC50 of 7 nM. Phase 3.
Front Immunol, 2022, 13:824746
J Med Chem, 2019, 62(4):1999-2007
J Med Chem, 2019, 62(4):1999-2007
S2364 Tanshinone I Tanshinone I, an active principle isolated from Salvia miltiorrhiza (Danshen), is structurally similar to tanshinone IIA and may possess similar cytotoxic effects on tumor cells.
Phytomedicine, 2022, 98:153958
Mol Med Rep, 2021, 23(1)40
Int Immunopharmacol, 2019, 10.1016/j.intimp.2019.106040
S2390 Polydatin Polydatin (Piceid) is a crystal component extracted from the root stem of perennial herbage Polygonum Cuspidatum Sieb.et Zucc.
Biochem Biophys Res Commun, 2021, 556:149-155
J Med Virol, 2019, 91(8):1440-1447
S3220 Trigonelline Trigonelline (Trigenolline) is a plant alkaloid and a major component of coffee and fenugreek with anti-degranulation, anti-diabetic, antioxidant, anti-inflammatory, and neuroprotective effects. Trigonelline inhibits FcεRI-mediated intracellular signaling pathways, such as phosphorylation of PLCγ1, PI3K, and Akt. Trigonelline (Trigenolline) also inhibits the microtubule formation in RBL-2H3 cells.
Biomed Pharmacother, 2021, 143:112204
S4089 Halobetasol Propionate Halobetasol Propionate (BMY-30056, CGP-14458) is an anti-inflammatory and a dermatologic agent commonly used to treat psoriasis. Halobetasol propionate is thought to act by the induction of phospholipase A2 (PLA2) inhibitory proteins.
S4255 Quinacrine 2HCl Quinacrine 2HCl is a lipophilic cationic drug with multiple actions that is commonly used as an anti-protozoal agent. Quinacrine is an effective phospholipase A2 inhibitor.
Toxicol In Vitro, 2022, 83:105420
Mol Oncol, 2020, 10.1002/1878-0261.12853
Mol Oncol, 2020, 10.1002/1878-0261.12853
S5913 Cambinol Cambinol is a novel uncompetitive nSMase2 inhibitor with a K i value of 7 μM (IC50 = 5 ± 1 μM).
S6522 ST 271 ST271 is a tyrphostin-like protein tyrosine kinase (PTK) inhibitor which inhibits phospholipase D (PLD) activity.
S6564 ML348 ML348 (GNF-Pf-1127) is a potent and selective APT1 (Acyl protein thioesterase 1)/lysophospholipase 1 (LYPLA1) inhibitor with Ki values of 280 nM and >10 μM for APT1 and APT2, respectively.
S7321 FIPI FIPI (5-Fluoro-2-indolyl deschlorohalopemide), a derivative of halopemide, is a potent and selective inhibitor of phospholipase D with IC50 of 25 nM and 20 nM for PLD1 and PLD2, respectively.
S7520 Darapladib (SB-480848) Darapladib (SB-480848) is a reversible lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor with IC50 of 0.25 nM. Phase 3.
Signal Transduct Target Ther, 2022, 7(1):59
Nat Metab, 2021, 3(6):762-773
Biochem Pharmacol, 2016, 102:78-96
S7609 GW4869 GW4869 (GW69A, GW554869A) is a neutral, noncompetitive inhibitor of sphingomyelinase (SMase) with an IC50 of 1 μM. It is selective for N-SMase, and does not inhibit acid SMase at up to at least 150 μM, also is a commonly used exosome inhibitor.
Front Cell Neurosci, 2022, 16:832140
Arthritis Res Ther, 2022, 24(1):44
FEBS J, 2022, 10.1111/febs.16447
S8011 U73122 U73122 is a potent phospholipase C (PLC) inhibitor, which reduces agonist-induced Ca2+ increases in platelets and PMN. U73122 potently inhibits human 5-lipoxygenase (5-LO).
J Exp Clin Cancer Res, 2022, 41(1):210
J Nanobiotechnology, 2022, 20(1):314
Cancers (Basel), 2022, 14(9)2222
S9478 Trans-4-Phenyl-3-buten-2-one Trans-4-Phenyl-3-buten-2-one (trans-Benzylideneacetone, trans-Benzalacetone, trans-Benzylideneacetone) is an inhibitor of the enzyme phospholipase A2 (PLA2). Trans-4-Phenyl-3-buten-2-one is used as a flavouring agent, a fragrance and a bacterial metabolite.
A5277 PLCG1 Rabbit Recombinant mAb PLCG1 Rabbit Recombinant mAb detects endogenous level of total PLCG1.
S0982 m-3M3FBS m-3M3FBS is a potent activator of phospholipase C (PLC) that stimulates a transient intracellular calcium concentration increase in neutrophils. m-3M3FBS induces apoptosis in monocytic leukemia cells.
S4107 Clofazimine Clofazimine (NSC-141046) is a rhimophenazine dye, originally developed for the treatment of tuberculosis, it has both antimicrobial and antiinflammatory activity, postulated mechanisms of action include intercalation of clofazimine with bacterial DNA and increasing levels of cellular phospholipase A2.
Blood, 2022, blood.2021014304
Microorganisms, 2022, 10(7)1421
ACS Infect Dis, 2020, acsinfecdis.0c00486
S9794 Melittin Melittin (MLT, Forapin, Forapine) is an activator of phospholipase A2 (PLA2) that stimulates the activity of the low molecular weight PLA2, while it does not the increase the activity of the high molecular weight enzyme.
EMBO J, 2022, e110439
S0053 CAY10593 (VU0155069) CAY10593 (VU0155069) is a selective phospholipase D1 (PLD1) antagonist that impairs human P2X7 acivation.
Free Radic Biol Med, 2021, S0891-5849(21)00821-2
Tags: Phospholipase (e.g. PLA) inhibitor|Phospholipase (e.g. PLA) agonist|Phospholipase (e.g. PLA) activator|Phospholipase (e.g. PLA) inducer|Phospholipase (e.g. PLA) antagonist|Phospholipase (e.g. PLA) signaling pathway|Phospholipase (e.g. PLA) assay kit