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Transferase inhibitors

Other Metabolism Related Inhibitors

Dehydrogenase DPP Aminopeptidase Procollagen C Proteinase P450 (e.g. CYP17) Phospholipase (e.g. PLA) Factor Xa PDE DHFR Carbonic Anhydrase
Cat.No. Product Name Information Product Use Citations Product Validations
S2799 FK866 (Daporinad) FK866 (Daporinad) effectively inhibits nicotinamide phosphoribosyltransferase (NMPRTase; Nampt) with IC50 of 0.09 nM in a cell-free assay. This compound triggers autophagy. Phase 1/2.
Adv Sci (Weinh), 2025, 12(33):e06599
J Neuroinflammation, 2025, 22(1):113
Cell Commun Signal, 2025, 23(1):348
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S7894 Tunicamycin Tunicamycin, an antibiotic, can potently inhibit the N-linked glycosylation (NLG) by competitively inhibiting UDP-GlcNAc-dolichol-phosphate N-acetylglucosamine-1 phosphate transferase (DPAGT1) activity and can target several types of tumors by reducing angiogenesis, inhibiting colony formation, and enhancing TRAIL-induced apoptosis.
Proc Natl Acad Sci U S A, 2025, 122(22):e2505975122
Cell Rep, 2025, 44(5):115686
Eur Endod J, 2024, 9(4):335-343
S9698 Ezatiostat Ezatiostat, a tripeptide analog of glutathione, is a peptidomimetic inhibitor of Glutathione S-transferase P1-1 (GSTP1-1). This compound activates c-Jun NH2 terminal kinase (JNK1) and ERK1/ERK2 and induces apoptosis.
S8244 Etomoxir sodium salt Etomoxir sodium salt ((R)-(+)-Etomoxir sodium salt) is an irreversible inhibitor of carnitine palmitoyltransferase-1 (CPT-1) on the outer face of the inner mitochondrial membrane. Etomoxir enhances palmitate-induced cell apoptosis.
J Clin Invest, 2025, e190215
Cell Commun Signal, 2025, 23(1):206
Cell Death Discov, 2025, 11(1):21
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S7465 FTI 277 HCl FTI 277 HCl is a potent and selective farnesyltransferase (FTase) inhibitor with IC50 of 500 pM, about 100-fold selectivity over the closely related GGTase I. This compound inhibits cell growth and induces apoptosis. This chemical is effective in clearing HDV viremia.
EMBO J, 2025, 44(4):1185-1219
BMC Biol, 2025, 23(1):233
PLoS One, 2025, 20(9):e0331440
Verified customer review of FTI 277 HCl
S9870 STM2457 STM2457 is a highly potent and selective first-in-class catalytic inhibitor of RNA Methyltransferase METTL3 with an IC50 of 16.9 nM. STM2457 is highly specific for METTL3 and showed no inhibition of other RNA methyltransferases.
Nat Commun, 2025, 16(1):4457
Cell Rep, 2025, S2211-1247(25)01101-5
J Virol, 2025, e0228424.
S7466 GGTI 298 TFA salt GGTI 298 is a geranylgeranyltransferase I inhibitor with ability to arrest human tumor cells in the G1 phase of the cell cycle and induce apoptosis.
bioRxiv, 2024, 10.1101/2024.01.16.575899
Nat Commun, 2023, 14(1):3251
Cell Struct Funct, 2021, 46(1):1-9
S4989 AOA (Aminooxyacetic acid) hemihydrochloride AOA (Aminooxyacetic acid) hemihydrochloride is an inhibitor of aminobutyrate aminotransferase involved in amino acid and polyamine metabolism. AOA hemihydrochloride is also a CBS (cystathionine β-synthase) inhibitor.
Clin Mol Hepatol, 2025, 10.3350/cmh.2024.0694
Pathogens, 2025, 14(5)439
bioRxiv, 2025, 2025.07.23.666333
S8608 ADOX (Adenosine Dialdehyde) ADOX (Adenosine Dialdehyde) is an adenosine analog and a S-adenosylmethionine-dependent methyltransferase inhibitor with an IC50 of 40 nM.
Nat Commun, 2024, 15(1):8971
EMBO J, 2023, e114558.
PLoS Biol, 2022, 20(2):e3001535
S8910 OSMI-4 OSMI-4 is an inhibitor of O-linked N-acetylglucosamine transferase (O-GlcNAc transferase, OGT) with EC50 of 3 μM in cells.
Mol Cell, 2025, 85(7):1411-1425.e8
Proc Natl Acad Sci U S A, 2025, 122(32):e2502687122
Neoplasia, 2025, 62:101142

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