Signaling Pathway Map

Research Area

  • Inhibitory Selectivity
  • Solubility
Catalog No. Product Name Solubility(25°C)
Water DMSO Alcohol
S1453 Tipifarnib <1 mg/mL 14 mg/mL <1 mg/mL
S2797 Lonafarnib <1 mg/mL 127 mg/mL 127 mg/mL
S2799 Daporinad (FK866, APO866) <1 mg/mL <1 mg/mL 78 mg/mL
S2674 A922500 <1 mg/mL 86 mg/mL <1 mg/mL
S8056 Lomeguatrib <1 mg/mL 65 mg/mL <1 mg/mL
S9231 Schisanhenol -1 mg/mL 81 mg/mL -1 mg/mL
S5336 Hecogenin <1 mg/mL <1 mg/mL <1 mg/mL
S5449 3-Methoxybenzamide -1 mg/mL 30 mg/mL -1 mg/mL
S4989 AOA hemihydrochloride 21 mg/mL 21 mg/mL -1 mg/mL
S7466 GGTI 298 TFA salt <1 mg/mL 100 mg/mL 100 mg/mL
S8244 Etomoxir (Na salt) 64 mg/mL 64 mg/mL 13 mg/mL
S4021 Tolcapone <1 mg/mL 55 mg/mL 55 mg/mL
S4589 Amodiaquine dihydrochloride dihydrate 29 mg/mL 92 mg/mL <1 mg/mL
S4743 Wogonin <1 mg/mL 56 mg/mL 3 mg/mL
S8608 Adenosine Dialdehyde (ADOX) 3 mg/mL 19 mg/mL <1 mg/mL
S3945 L-Cycloserine 20 mg/mL 8 mg/mL -1 mg/mL
S3658 O6-Benzylguanine <1 mg/mL 48 mg/mL 12 mg/mL
S7467 LB42708 <1 mg/mL 100 mg/mL 86 mg/mL
S4280 Meclofenoxate (Centrophenoxine) HCl 58 mg/mL 58 mg/mL 58 mg/mL
S7192 PF-04620110 <1 mg/mL 49 mg/mL <1 mg/mL
S7465 FTI 277 HCl 17 mg/mL 96 mg/mL 14 mg/mL
Catalog No. Information Product Use Citations Product Validations


Tipifarnib (R115777) is a potent and specific farnesyltransferase (FTase) inhibitor with IC50 of 0.6 nM, its anti-proliferative effects are most prominent in H-ras or N-ras mutant cells. Phase 3.



Lonafarnib is an orally bioavailable FPTase inhibitor for H-ras, K-ras-4B and N-ras with IC50 of 1.9 nM, 5.2 nM and 2.8 nM in cell-free assays, respectively. Phase 3.


Daporinad (FK866, APO866)

Daporinad (FK866, APO866) effectively inhibits nicotinamide phosphoribosyltransferase (NMPRTase) with IC50 of 0.09 nM in a cell-free assay. Phase 1/2.



A922500 is an inhibitor for human and mouse DGAT-1 with IC50 of 7 nM and 24 nM, respectively, good selectivity over related acyltransferases, hERG, and a panel of anti-targets.



Lomeguatrib is a potent inhibitor of O6-alkylguanine-DNA-alkyltransferase with IC50 of 5 nM.



Schisanhenol is a compound derived from the fruit of a traditional Chinese herb Schisandra rubriflora, exhibiting strong inhibition toward UGT2B7.



Hecogenin, a steroid saponin isolated from Agave sisalana, is a potent and highly selective inhibitor of UGT1A4 with an IC50 value of 1.5 μM.



3-Methoxybenzamide is a competitive inhibitor of poly(ADP-ribose) synthetase with Ki values of less than 2 μM and also inhibits ADP-ribosyltransferase (ADPRT)


AOA hemihydrochloride

Aminooxyacetic acid is an inhibitor of aminobutyrate aminotransferase involved in amino acid and polyamine metabolism.


GGTI 298 TFA salt

GGTI 298 is a geranylgeranyltransferase I inhibitor with ability to arrest human tumor cells in the G1 phase of the cell cycle and induce apoptosis.


Etomoxir (Na salt)

Etomoxir is an irreversible inhibitor of carnitine palmitoyltransferase-1 (CPT-1) on the outer face of the inner mitochondrial membrane.



Tolcapone is a selective, potent and reversible of catechol-O-methyl transferase (COMT) inhibitor with Ki of 30 nM.


Amodiaquine dihydrochloride dihydrate

Amodiaquine is a potent, non-competitive inhibitor of histamine N-methyl transferase with estimated Ki of 18.6 nM. It is also used as an antimalarial and anti-inflammatory agent.



Wogonin, a natural and biologically-active flavonoid found in plants, is an inhibitor of CDK9 and does not inhibit CDK2, CDK4 and CDK6 at doses that inhibit CDK9 activity; Also inhibits N-acetyltransferase.


Adenosine Dialdehyde (ADOX)

Adenosine Dialdehyde (ADOX) is an adenosine analog and S-adenosylmethionine-dependent methyltransferase inhibitor with an IC50 of 40 nM.



L-Cycloserine is a potent inhibitor of the sphingolipid pathway via inhibiting 3-ketodihydrosphingosine synthetase. It also inhibits HIV-1 cytopathic effects, replication, and infectivity.



O6-Benzylguanine (O6-BG) is a potent O6-alkylguanine DNA alkyltransferase (AGT) inactivator.



LB42708 is an orally active farnesyltransferase (FTase) inhibitor with IC50 of 0.8, 1.2, and 2.0 nM toward H-ras, N-ras, and K-ras, respectively.


Meclofenoxate (Centrophenoxine) HCl

Meclofenoxate (Centrophenoxine) HCl is an anti-aging drug used to treat the symptoms of senile dementia and Alzheimer's disease, and also inhibits the activity of cholinephosphotransferase.



PF-04620110 is an orally active, selective and potent diglyceride acyltransferase-1 (DGAT1) inhibitor with IC50 of 19 nM.


FTI 277 HCl

FTI 277 HCl is the methyl ester of FTI 277, which is a potent and selective farnesyltransferase (FTase) inhibitor with IC50 of 500 pM, about 100-fold selectivity over the closely related GGTase I.

Tags: Transferase activity | Transferase inhibition | Transferase activity | protein transferase | farnesyltransferase | DNA methyltransferase cancer | DNA methyltransferase activity | DNA methyltransferase assay | DNA methyltransferase mechanism | farnesyl transferase assay | Transferase inhibitor review